A5011045570- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- ECG Monitoring and Analysis
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Sports injuries and prevention
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Aortic Disease and Treatment Approaches
- Viral Infections and Immunology Research
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Infective Endocarditis Diagnosis and Management
- Computational Drug Discovery Methods
- Analog and Mixed-Signal Circuit Design
- Receptor Mechanisms and Signaling
- Cardiovascular and exercise physiology
- Cardiac Imaging and Diagnostics
- Aortic Thrombus and Embolism
- Ion Transport and Channel Regulation
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
St George's, University of London
2016-2025
University Hospitals Birmingham NHS Foundation Trust
2023-2025
Queen Elizabeth Hospital Birmingham
2023-2025
Genomics (United Kingdom)
2025
City St George's, University of London
2025
St George’s University Hospitals NHS Foundation Trust
2017-2024
University of Birmingham
2024
University Hospitals of North Midlands NHS Trust
2021
University Hospital Lewisham
2018
National University Heart Centre Singapore
2017
Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized by myocardial fibrofatty replacement and increased risk of sudden cardiac death (SCD). Originally described as a right ventricular disease, ACM increasingly recognized biventricular entity. We evaluated pathological, genetic, clinical associations in large SCD cohort.We investigated 5205 consecutive cases referred to national pathology center between 1994 2018. Hearts tissue blocks were examined expert...
Aim To investigate the accuracy of recently published international recommendations for ECG interpretation in young athletes a large cohort white and black adolescent soccer players. Methods 11 168 players (mean age 16.4±1.2 years) were evaluated with health questionnaire, echocardiogram; 10 581 (95%) male 163 (91%) white. ECGs retrospectively analysed according to (1) 2010 European Society Cardiology (ESC) recommendations, (2) Seattle criteria, (3) refined criteria (4) athletes. Results The...
To characterize the most common electrocardiographic (ECG) abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), including anterior T-wave inversion (TWI) and to compare characteristics of TWI ARVC a cohort young healthy athletes sedentary individuals.The study population consisted 162 definite diagnosis 129 controls TWI. Cardiac disease was excluded all after comprehensive diagnostic work-up. The ECG abnormal 131 (81%). Abnormalities included (n = 82, 51%),...
Electrophysiological, imaging, and pathological studies have reported the presence of subtle structural abnormalities in hearts from patients with Brugada syndrome (BrS). However, data concerning disease involvement outside right ventricular outflow tract are limited. This study sought to characterize distribution myocardial fibrosis a cohort decedents experiencing sudden cardiac death caused by BrS. The authors evaluated 28 whole consecutive cases attributed BrS 29 comparator group...
Idiopathic left ventricular hypertrophy (LVH) is defined as LVH in the absence of myocyte disarray or secondary causes. It unclear whether idiopathic represents phenotypic spectrum hypertrophic cardiomyopathy (HCM) it a unique disease entity. We aimed to ascertain prevalence HCM first-degree relatives decedents from sudden death with at autopsy. Decedents also underwent molecular autopsy identify presence pathogenic variants genes implicated HCM.
Preparticipation screening for cardiovascular disease in young athletes with electrocardiography is endorsed by the European Society of Cardiology and several major sporting organizations. One concerns ECG as a test relates to potential variation interpretation. We investigated degree interpretation its financial impact among cardiologists differing experience.Eight (4 experience athletes) each reported 400 ECGs consecutively screened according 2010 recommendations, Seattle criteria, refined...
Background: Familial cascade screening is well established in patients with heritable cardiac disease and cases of sudden arrhythmic death syndrome. The clinical benefit family idiopathic ventricular fibrillation (IVF) unknown. Methods: Patients IVF were identified from national institutional registries. All underwent systematic comprehensive evaluation to exclude identifiable causes arrest a minimum requirement ECG, (echocardiogram or magnetic resonance imaging) coronary imaging, exercise...
Brugada syndrome (BrS) diagnosis and risk stratification rely on the presence of a spontaneous type 1 (spT1) electrocardiogram (ECG) pattern; however, its fluctuations may lead to misdiagnosis underestimation. This study aims assess role for repeat high precordial (HPL) resting ambulatory ECG monitoring in identifying spT1, evaluate prognostic role.
Atrial fibrillation (AF) ablation can lead to oesophageal thermal injuries (ETI). These are thought be the precursor of much rarer but frequently fatal atrio-oesophageal fistulas. Many centers performing AF routinely use temperature monitoring (ETM). This meta-analysis aims determine utility ETM in preventing ETI context radiofrequency catheter AF.
Abstract Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic is a rare inherited disease with incomplete penetrance and an environmental component. Although disease, ARVC common cause of sudden cardiac death in young adults. Data on the different stages remains scarce. The purpose this study to describe initial presentation phenotype definite non-definite for patients seen at tertiary service. Methods This single centre, observational cohort Inherited Cardiac...
The implications of a drug-induced type 1 Brugada ECG pattern following sodium channel blocker provocation (SCBP) are not fully understood.
Abstract Background Idiopathic ventricular fibrillation (VF) is a diagnosis of exclusion in subjects with an unexplained cardiac arrest and no evidence overt structural or electrical abnormalities (1). It can be associated early repolarisation pattern (ERP)(2). Data on the evolution ECG this population are lacking. Purpose To compare baseline characteristic idiopathic VF survivors age gender matched controls, investigate if presence ERP at predictor risk. Methods Forty-nine evaluated our...
Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare genetic disorder associated with an elevated risk of life-threatening arrhythmias and progressive impairment. Risk stratification essential to prevent major adverse cardiac events (MACE). Our study aimed investigate the incremental value strain measured by two-dimensional speckle-tracking echocardiography in predicting MACE ARVC patients compared conventional echocardiographic parameters. Methods Results This was...
Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): British Heart Foundation Background A spontaneous type 1 Brugada (spT1-BrS) pattern is a recognised marker arrhythmic risk. However, its fluctuations may underestimate the risk in subjects with concealed T1-BrS at presentation. Aim To investigate yield repeat resting and high-lead 12-lead ECG additional role 24-hour Holter monitoring leads V1 V2 standard high precordial positions (12-HPL Holter), evaluate...
Abstract Funding Acknowledgements Type of funding sources: Other. Main source(s): Grant from the charitable organisation Cardiac Risk in Young. Background Pre-participation cardiac screening (PPS) professional rugby players United Kingdom consists an ECG-based evaluation. However, structural abnormalities that would not manifest on ECG, such as aortic dilatation might be underdiagnosed and dissection has previously been identified a cause sudden death athletes (1). Purpose To trial focused...
Abstract Background Isoprenaline is widely used in the treatment of symptomatic bradycardia. Myocardial infarction precipitated by therapeutic use isoprenaline has not been reported literature. Case summary We describe case a 67-year-old male patient who presented to our institution with Mobitz type II 2:1 atrioventricular block. He had several-month history unexplained syncope. several cardiovascular risk factors but did have diagnosis coronary artery disease. On admission, he was dizziness...
Abstract Background Aortic size varies between individuals and is influenced by age, gender, body blood pressure. There are numerous studies aimed at defining normative aortic root measurements, but the vast majority of these in older adults, or limited a small sample size. Purpose To screen large number young (≤35 years) to understand rate growth, validate current guideline cut-offs for measurements this age group compare findings males versus females. Methods Individuals ≥ 16 years old who...