A5017927929- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- ECG Monitoring and Analysis
- Cardiac Arrest and Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
- Ion channel regulation and function
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Health and Mental Health
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Venous Thromboembolism Diagnosis and Management
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Nitric Oxide and Endothelin Effects
- Cardiovascular Function and Risk Factors
- Non-Invasive Vital Sign Monitoring
Sunnybrook Health Science Centre
2023-2025
Health Sciences Centre
2023-2025
Tuen Mun Hospital
2025
University of Toronto
2023-2024
University of California, San Francisco
2020-2024
Seton Medical Center
2024
Toronto Public Health
2023-2024
University of British Columbia
2014-2023
Western NSW Local Health District
2022-2023
Dalhousie University
2020-2023
Advanced generation ablation technologies have been developed to achieve more effective pulmonary vein isolation (PVI) and minimize arrhythmia recurrence after atrial fibrillation (AF) ablation.We randomly assigned 346 patients with drug-refractory paroxysmal AF contact force-guided radiofrequency (CF-RF; n=115), 4-minute cryoballoon (Cryo-4; or 2-minute (Cryo-2; n=116). Follow-up was 12 months. The primary outcome time first documented of symptomatic asymptomatic tachyarrhythmia (AF,...
Abstract Aims Genetic testing is recommended in specific inherited heart diseases but its role remains unclear and it not currently unexplained cardiac arrest (UCA). We sought to assess the yield clinical utility of genetic UCA using whole-exome sequencing (WES). Methods results Survivors requiring external defibrillation were included from Cardiac Arrest Survivor with Preserved Ejection fraction Registry. Whole-exome was performed, followed by assessment rare variants previously reported...
Congenital long QT syndrome (LQTS) is associated with syncope, ventricular arrhythmias, and sudden death. Half of patients LQTS have a normal or borderline-normal interval despite often being detected by prolongation on resting electrocardiography (ECG).
The Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER) enrolls patients apparently unexplained cardiac arrest and no evident disease to identify the pathogenesis of through systematic clinical testing. Exercise testing, drug provocation, advanced imaging, genetic testing may be useful when a cause is not apparent.The first 200 survivors from 14 centers across Canada were evaluated determine results investigation follow-up (age, 48.6±14.7 years, 41% female). Patients...
Abstract Aims Atrial fibrillation (AF) is the most common cardiac rhythm disorder. Emerging evidence supporting efficacy of catheter ablation in managing AF has led to increased demand for this therapy, potentially outpacing capacity perform procedure. Mismatch between and results wait-times which have not been comprehensively evaluated at a population level. Additionally, consequences such delays ablation, namely risk hospitalization or adverse events, studied. Methods This observational...
<h3>Importance</h3> Postoperative atrial fibrillation (POAF) occurring after cardiac surgery is associated with adverse outcomes. Whether POAF persists beyond discharge not well defined. <h3>Objective</h3> To determine whether continuous rhythm monitoring enhances detection of among surgical patients during the first 30 days hospital compared usual care. <h3>Design, Setting, and Participants</h3> This study an investigator-initiated, open-label, multicenter, randomized clinical trial...
Previous studies demonstrated Ganoderma lucidum polysaccharides (GL-PS), a form of bioactive β-glucan can stimulate the maturation monocyte-derived dendritic cells (DC). The question how leukemic especially in monocytic lineage respond to GL-PS stimuli remains unclear. In this study, we used vitro culture model with cell-lines THP-1 and U937 as effectors for proliferation responses DCs induction. We treated purified (100 μg/mL) or GM-CSF/IL-4. alone induced proliferative response on both but...
Estrogen has antihypertensive and vasorelaxing properties, partly via activation of endothelial nitric-oxide synthase (eNOS). Recently, neuronal (nNOS) been detected in vascular cells, although the significance this is unclear. was found to stimulate nNOS certain cultured cells. We hypothesized that estrogen regulates tone endothelium-derived nNOS. Human umbilical vein cells were used test whether acute (5 min) stimulation with 17β-estradiol (E2) at 1 or 10 nM affected activity. Small...