A5022991046- Cardiovascular Effects of Exercise
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Viral Infections and Immunology Research
- Medical Imaging and Pathology Studies
- Cardiomyopathy and Myosin Studies
- COVID-19 Clinical Research Studies
- Occupational and environmental lung diseases
- Transplantation: Methods and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Issues in Pregnancy
- Quantum Computing Algorithms and Architecture
- COVID-19 diagnosis using AI
- Pediatric health and respiratory diseases
- Cardiac Valve Diseases and Treatments
- Cardiac Health and Mental Health
- Colorectal Cancer Screening and Detection
- Sports injuries and prevention
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Cardiac Arrhythmias and Treatments
- Artificial Intelligence in Healthcare and Education
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cardiac electrophysiology and arrhythmias
- Pleural and Pulmonary Diseases
Imperial College London
2017-2024
Guy's and St Thomas' NHS Foundation Trust
2021-2024
Harefield Hospital
2017-2024
Lung Institute
2019-2024
Royal Brompton & Harefield NHS Foundation Trust
2017-2023
Royal Brompton Hospital
2016-2023
Matrix Research (United States)
2016
African Organisation for Research and Training in Cancer
2016
Foundation for Growth Science
2016
Institute of Cardiology
2016
Abstract Imaging intact human organs from the organ to cellular scale in three dimensions is a goal of biomedical imaging. To meet this challenge, we developed hierarchical phase-contrast tomography (HiP-CT), an X-ray phase propagation technique using European Synchrotron Radiation Facility (ESRF)’s Extremely Brilliant Source (EBS). The spatial coherence ESRF-EBS combined with our beamline equipment, sample preparation and scanning developments enabled us perform non-destructive,...
Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized by myocardial fibrofatty replacement and increased risk of sudden cardiac death (SCD). Originally described as a right ventricular disease, ACM increasingly recognized biventricular entity. We evaluated pathological, genetic, clinical associations in large SCD cohort.We investigated 5205 consecutive cases referred to national pathology center between 1994 2018. Hearts tissue blocks were examined expert...
Background: Acute myocarditis is an inflammatory condition that may herald the onset of dilated cardiomyopathy (DCM) or arrhythmogenic (ACM). We investigated frequency and clinical consequences DCM ACM genetic variants in a population-based cohort patients with acute myocarditis. Methods: This was 336 consecutive enrolled London Maastricht. All participants underwent targeted DNA sequencing for well-characterized cardiomyopathy-associated genes comparison to healthy controls (n=1053)...
A wide range of cardiac symptoms have been observed in COVID-19 patients, often significantly influencing the clinical outcome. While pathophysiology pulmonary manifestation has substantially unraveled, underlying pathomechanisms involvement are largely unknown. In this multicentre study, we performed a comprehensive analysis heart samples from 24 autopsies with confirmed SARS-CoV-2 infection and compared them to age-matched Influenza H1N1 (n = 16), lymphocytic non-influenza myocarditis...
We introduce a method for photoacoustic imaging of the carotid artery, tailored toward detection lipid-rich atherosclerotic lesions. A common human artery was obtained at autopsy, embedded in neck mimicking phantom and imaged with multimodality system using interstitial illumination. Light delivered through 1.25-mm-diameter optical probe that can be placed pharynx, allowing to illuminated from within body. Ultrasound signal is achieved by an external 8-MHz linear array coupled ultrasound...
Spontaneous coronary artery dissection (SCAD) is a cause of acute syndromes and in rare cases sudden cardiac death (SCD). Connective tissue abnormalities, inflammation, increased vasa vasorum (VV) density, fibromuscular dysplasia have all been implicated the pathophysiology SCAD but not previously systematically assessed. We designed study to investigate histological dermal collagen ultrastructural findings SCAD.Thirty-six autopsy were compared with 359 survivors. Coronary myocardial...
Aneurysm-osteoarthritis syndrome characterized by unpredictable aortic aneurysm formation, is caused SMAD3 mutations. part of the SMAD2/3/4 transcription factor, essential for TGF-β-activated transcription. Although TGF-β-related gene mutations result in aneurysms, underlying mechanism unknown. Here, we examined formation and progression Smad3−/− animals.Smad3−/− animals developed aneurysms rapidly, resulting premature death. Aortic wall immunohistochemistry showed no increase extracellular...
Severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV‑2), the causative viral agent for ongoing COVID‑19 pandemic, enters its host cells primarily via binding of SARS‑CoV‑2 spike (S) proteins to angiotensin‑converting enzyme 2 (ACE2). A number other cell entry mediators have also been identified, including neuropilin‑1 (NRP1) and transmembrane protease serine (TMPRSS2). More recently, it has demonstrated that 4 (TMPRSS4) along with TMPRSS2 activate S proteins, enhance infection...
We present the initial 2-year results of CardioCel® patch (Admedus Regen Pty Ltd, Perth, WA, Australia) implantation in paediatric patients with congenital heart diseases.This was a single-centre retrospective study prospectively collected data all aged 18 years and under operated for disease. The introduced 2014, clinical practice committee approval special consent case an Ozaki procedure. Standard follow-up performed systematic exams echocardiograms. In reoperation or graft failure,...
Unlike the vast amount of animal data available on recellularization allogenic decellularized heart valves (DHVs), there have only been sporadic histologic reports such grafts in humans.Two experienced cardiac pathologists independently evaluated human specimens obtained during reoperation between December 2010 and April 2017 DHVs seven categories after automated staining (scores: 0 to 6) comparison with published data. An optimal result 42 points was classified as 100%.We found that 364...
Nuclear grading systems for epithelioid malignant pleural mesothelioma (MPM) have been proposed but it remains uncertain if they could be applied in a biopsy-heavy setting. Using the system, we conducted an independent, external validation study using 563 consecutive cases of MPM diagnosed at our institution between 2003 and 2017, which 87% patients underwent biopsies only. The median number sites sampled was 1, with maximum tissue dimension 17 mm (biopsy) 150 (resection). overall survival...
Mesothelioma is classified into three histological subtypes, epithelioid, sarcomatoid, and biphasic, according to the relative proportions of epithelioid sarcomatoid tumor cells present. Current guidelines recommend that component each mesothelioma quantified, as a higher percentage pattern in biphasic shows poorer prognosis. In this work, we develop dual-task graph neural network (GNN) architecture with ranking loss learn model capable scoring regions tissue down cellular resolution. This...
Studies on the prognostic value of serial biomarker assays for future occurrence allograft rejection (AR) are scarce. We examined whether repeated measurements NT-pro-B-type natriuretic peptide (NT-proBNP), troponin T (TropT) and C-reactive protein (CRP) predict AR.From 2005 to 2010, 77 consecutive heart transplantation (HTx) recipients were included. The NT-proBNP, TropT, CRP measured at 16 ± 4 (mean standard deviation) routine endomyocardial biopsy surveillance visits during first year...
Quantum machine learning with quantum kernels for classification problems is a growing area of research. Recently, kernel alignment techniques that parameterise the have been developed, allowing to be trained and therefore aligned specific dataset. While promising technique, it has hampered by considerable training costs because full matrix must constructed at every iteration. Addressing this challenge, we introduce novel method seeks balance efficiency performance. We present sub-sampling...
Aims Restrictive allograft syndrome ( RAS ) and idiopathic pleuroparenchymal fibroelastosis IPPFE are two different diseases reported to share the same histology. relates chronic dysfunction in lung transplantation, with being a rare condition native lungs. Our aim is compare their histologies alongside biopsies of usual interstitial pneumonia UIP ), determine if there differences that might help elucidate pathogenesis. Methods results We selected four postmortem lungs from patients who...
Abstract Necrotizing eosinophilic myocarditis is a rare but potentially fatal condition that requires prompt recognition and treatment. We describe case of young athlete presenting with chest pain breathlessness, evidence rapidly deteriorating cardiac function. The was successfully treated corticosteroids, no residual myocardial damage. This the first reported to demonstrate utility magnetic resonance imaging for diagnosis monitoring response It also highlights value endomyocardial biopsy in...
Aims: Increasing evidence supports a role for the angiotensin II-AT1-receptor axis in aneurysm development. Here, we studied whether counteracting this via stimulation of AT2 receptors is beneficial. Such occurs naturally during AT1-receptor blockade with losartan, but not renin inhibition aliskiren. Methods and results: Aneurysmal homozygous fibulin-4R/R mice, displaying four-fold reduced fibulin-4 expression, were treated placebo, aliskiren, or β-blocker propranolol from day 35 to 100....
Nuclear grade has been recently validated as a powerful prognostic tool in epithelioid malignant pleural mesothelioma (E-MPM). In other studies histological parameters including pleomorphic features and growth patterns were also shown to exert impact. The primary aims of our study are (i) externally validate the role E-MPM (ii) investigate if evaluating pattern addition 2-tier nuclear improves prognostication.614 consecutive cases from institution over period 15 years retrospectively...
ABSTRACT Human organs are complex, three-dimensional and multiscale systems. Spatially mapping the human body down through its hierarchy, from entire to their individual functional units specialised cells, is a major obstacle fully understanding health disease. To meet this challenge, we developed hierarchical phase-contrast tomography (HiP-CT), an X-ray phase propagation technique utilising European Synchrotron Radiation Facility’s Extremely Brilliant Source: world’s first high-energy 4 th...
Malignant Mesothelioma is a difficult to diagnose and highly lethal cancer usually associated with asbestos exposure. It can be broadly classified into three subtypes: Epithelioid, Sarcomatoid, hybrid Biphasic subtype in which significant components of both the previous subtypes are present. Early diagnosis identification informs treatment help improve patient outcome. However, subtyping malignant mesothelioma, specifically recognition transitional features from routine histology slides has...
In addition to the angiotensin‑converting enzyme 2 (ACE2), a number of host cell entry mediators have been identified for severe acute respiratory syndrome coronavirus‑2 (SARS‑CoV‑2), including transmembrane protease serine 4 (TMPRSS4). The authors recently demonstrated upregulation TMPRSS4 in 11 different cancers, as well its specific expression within central nervous system using <em>in silico</em> tools. present study aimed expand initial observations and, immunohistochemistry, protein...