A5048326229- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- 3D Printing in Biomedical Research
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Counseling Practices and Supervision
- Child and Adolescent Psychosocial and Emotional Development
- Microfluidic and Bio-sensing Technologies
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Ion channel regulation and function
- Breast Cancer Treatment Studies
- ECG Monitoring and Analysis
- Diabetes Treatment and Management
- Neurological disorders and treatments
- Blood Pressure and Hypertension Studies
- Genetic Associations and Epidemiology
- Mental Health Treatment and Access
- Venous Thromboembolism Diagnosis and Management
- Cardiac tumors and thrombi
- Bariatric Surgery and Outcomes
- Cardiovascular and Diving-Related Complications
Population Health Research Institute
2017-2024
Hamilton Health Sciences
2017-2024
McMaster University
2017-2024
Cellular Dynamics International (United States)
2024
Impact
2018-2023
Hamilton General Hospital
2022
London School of Hygiene & Tropical Medicine
2021
Health Sciences Centre
2020-2021
John F. Kennedy Medical Center
2020
Richmond Area Multi-Services
2019
Subclinical atrial fibrillation is short-lasting and asymptomatic can usually be detected only by long-term continuous monitoring with pacemakers or defibrillators. associated an increased risk of stroke a factor 2.5; however, treatment oral anticoagulation uncertain benefit. We conducted trial involving patients subclinical lasting 6 minutes to 24 hours. Patients were randomly assigned in double-blind, double-dummy design receive apixaban at dose 5 mg twice daily (2.5 when indicated)...
A substantial proportion of patients with atrial fibrillation (AF) die noncardiovascular causes, and recent studies suggest a link between AF cancer.To evaluate the associations cancer in large, long-term prospective cohort study.In this study, total 34 691 women 45 years or older free AF, cardiovascular disease, at baseline were prospectively followed up 1993 2013, for incident malignant within Women's Health Study, randomized clinical trial aspirin vitamin E prevention disease cancer. Cox...
Background: Bariatric surgery has been shown to significantly reduce cardiovascular risk factors. However, whether can major adverse events (MACE), especially in patients with established disease, remains poorly understood. The present study aims determine the association between bariatric and MACE among disease severe obesity. Methods: This was a propensity score–matched cohort using province-wide multiple-linked administrative databases Ontario, Canada. Patients previous ischemic heart or...
Atrial fibrillation (AF) is a major cause of preventable strokes. Screening asymptomatic individuals for AF may increase anticoagulant use stroke prevention.To evaluate 2 home-based screening interventions.This multicenter randomized clinical trial recruited from primary care practices aged 75 years or older with hypertension and without known AF. From April 5, 2015, to March 26, 2019, 856 participants were enrolled 48 practices.The control group received standard (routine follow-up plus...
Background: Atrial fibrillation (AF) and heart failure (HF) frequently coexist can be challenging to treat. Pharmacologically based rhythm control of AF has not proven superior rate control. Ablation-based was compared with evaluate if clinical outcomes in patients HF could improved. Methods: This a multicenter, open-label trial blinded outcome evaluation using central adjudication committee. Patients high-burden paroxysmal (>4 episodes 6 months) or persistent (duration <3 years) AF,...
Abstract Background and Aims Mineralocorticoid receptor antagonists (MRAs) improve cardiovascular outcomes in a variety of settings. This study aimed to assess whether cardioprotective effects MRAs are modified by heart failure (HF) atrial fibrillation (AF) status their impact on AF events. Methods MEDLINE, Embase, Cochrane Central databases were searched 24 March 2023 for randomized controlled trials evaluating the efficacy as compared with placebo or usual care reducing events patients at...
Background— The clinical diagnosis of long-QT syndrome (LQTS) remains challenging when ECG abnormalities are borderline or intermittent. Despite issues with access, cost, and heterogeneity LQTS mutations, genetic testing the diagnostic gold standard for LQTS. We sought to develop a provocative strategy unmask phenotype relate this results testing. Methods Results— From 1995 2008, 159 consecutive patients suspected underwent that consisted modified Bruce protocol treadmill exercise test, ECGs...
Inflammation may promote atrial fibrillation (AF) recurrence after catheter ablation. This study aimed to evaluate a short-term anti-inflammatory treatment with colchicine following ablation of AF.
Transmural scar occupying left ventricular (LV) pacing regions has been associated with reduced response to cardiac resynchronization therapy (CRT). However, spatial influences of lead tip delivery relative at both sites remain poorly explored. This study evaluated distribution LV and right (RV) placement through coregistration late gadolinium enhancement MRI computed tomographic (CT) findings. Influences on CRT were assessed by serial echocardiography.Sixty patients receiving underwent...
<h3>Objective</h3> Limited data exist on the association between menopause and atrial fibrillation (AF). We sought to examine relationship menopausal age, postmenopausal hormone therapy (PHT) use incident AF. <h3>Methods</h3> The Women's Health Study (WHS) enrolled 39 876 female health professionals 1992 1995. prospectively examined 30 034 women in WHS using Cox proportional-hazard models. Participants were free of cardiovascular disease AF at baseline had not undergone hysterectomy without...
Breast conserving surgery followed by radiation therapy has been accepted as an alternative to mastectomy in the management of patients with early-stage breast cancer. Over past decade there increasing interest a variety techniques designed treat only portion deemed be at high risk for local recurrence (partial-breast irradiation [PBI]) and shorten duration treatment (accelerated partial-breast [APBI]). To consider issues regarding equivalency various approaches address future needs...
Background: Atrial fibrillation (AF) is often detected for the first time in patients who are hospitalized another reason. Long-term risks AF recurrence these unclear. Objective: To estimate risk with new-onset during a hospitalization noncardiac surgery or medical illness compared matched population without AF. Design: Matched cohort study. (ClinicalTrials.gov: NCT03221777) Setting: Three academic hospitals Hamilton, Ontario, Canada. Participants: The study enrolled had transient For each...
A method of incorporating dose‐volume considerations within the framework conventional linear programming is presented. This suitable for optimization beam weights and angles using a conformal treatment philosophy (i.e., tailoring high‐dose region to target volume only). Dose‐volume constraints are introduced concept that volumes normal tissue nearer will be allowed higher dose than distal volume. Each involved structure divided into low‐dose volumes. These two partitions represented by...
Thousands of refugees from around the world resettle in United States every year. Many suffer mental health disorders as a result experiences living or escaping their turbulent homelands, and many also experience issues they settle new host countries. As such, it is important to intervene during early stages refugee resettlement help prevent mitigate illness symptoms. However, because several access utilization barriers, such stigma, are not apt receive needed services. Moreover, traditional...
Abstract Aims There is uncertainty about whether and how to perform screening for atrial fibrillation (AF). To estimate the incidence of previously undetected AF that would be captured using a continuous 14-day ECG monitor associated risk stroke. Methods results We analysed data from cohort patients &gt;65 years old with hypertension pacemaker, but without known AF. For each participant, we simulated 1000 monitors by randomly selecting windows in 6 months following enrolment calculated...