A5027918729- Breast Cancer Treatment Studies
- Patient-Provider Communication in Healthcare
- Breast Lesions and Carcinomas
- Advanced Breast Cancer Therapies
- BRCA gene mutations in cancer
- Palliative Care and End-of-Life Issues
- Global Cancer Incidence and Screening
- Breast Implant and Reconstruction
- Estrogen and related hormone effects
- Cancer survivorship and care
- Advanced Radiotherapy Techniques
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Metabolism, Diabetes, and Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Advances in Oncology and Radiotherapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Clinical practice guidelines implementation
- Patient Dignity and Privacy
- Brain Metastases and Treatment
- Cancer Diagnosis and Treatment
- Management of metastatic bone disease
McMaster University
2016-2025
Hamilton Health Sciences
2013-2025
Juravinski Cancer Centre
2016-2025
Jacobs (United States)
2024-2025
University at Buffalo, State University of New York
2023-2024
Isabela State University
2023
Ontario Clinical Oncology Group
2006-2022
Cancer Care Ontario
2003-2020
UCLouvain Saint-Louis Brussels
2019
Princess Margaret Cancer Centre
2004-2019
The recurrence score based on the 21-gene breast cancer assay predicts chemotherapy benefit if it is high and a low risk of in absence low; however, there uncertainty about for most patients, who have midrange score.We performed prospective trial involving 10,273 women with hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, axillary node-negative cancer. Of 9719 eligible patients follow-up information, 6711 (69%) had 11 to 25 were randomly assigned receive...
<h2>ABSTRACT</h2> The 14th St Gallen International Breast Cancer Conference (2015) reviewed substantial new evidence on locoregional and systemic therapies for early breast cancer. Further experience has supported the adequacy of tumor margins defined as ‘no ink invasive or DCIS' safety omitting axillary dissection in specific cohorts. Radiotherapy trials support irradiation regional nodes node-positive disease. Considering subdivisions within luminal disease, Panel was more concerned with...
The optimal fractionation schedule for whole-breast irradiation after breast-conserving surgery is unknown.We conducted a study to determine whether hypofractionated 3-week of as effective 5-week schedule. Women with invasive breast cancer who had undergone and in whom resection margins were clear axillary lymph nodes negative randomly assigned receive either at standard dose 50.0 Gy 25 fractions over period 35 days (the control group) or 42.5 16 22 hypofractionated-radiation group).The risk...
Prior studies with the use of a prospective-retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, prospectively conducted study in uniformly treated population provides highest level evidence supporting clinical validity and usefulness biomarker.We performed prospective trial involving women hormone-receptor-positive, human epidermal growth factor receptor type 2 (HER2)-negative, axillary...
Most women with breast cancer who undergo breast-conserving surgery receive whole-breast irradiation. We examined whether the addition of regional nodal irradiation to improved outcomes.
The vital role played by family caregivers in supporting dying cancer patients is well recognized, but the burden and economic impact on poorly understood. We prospectively examined psychosocial, occupational of caring for a person with terminal illness.We studied 89 women advanced breast receiving care at either Ottawa or Hamilton regional centres Ontario. Patients were followed until their death study completion 3 years. identified principal caregiver to participate study. Karnofsky...
OBJECTIVE: To determine indications for the use of postmastectomy radiotherapy (PMRT) patients with invasive breast cancer involved axil-lary lymph nodes or locally advanced disease who receive systemic therapy. These guidelines are intended in care outside clinical trials. POTENTIAL INTERVENTION: The benefits and risks PMRT such patients, as well subgroups these were considered. details technique also evaluated. OUTCOMES: outcomes considered included freedom from local-regional recurrence,...
Purpose Radiotherapy reduces the absolute risk of breast cancer mortality by a few percentage points in suitable women but can cause second or heart disease decades later. We estimated long-term risks modern radiotherapy. Methods First, systematic literature review was performed lung and doses regimens published during 2010 to 2015. Second, individual patient data meta-analyses 40,781 randomly assigned radiotherapy versus no 75 trials yielded rate ratios (RRs) for primary cancers...
Background: Breast irradiation after lumpectomy is an integral component of breast-conserving therapy that reduces the local recurrence breast cancer. Because optimal fractionation schedule (radiation dose given in a specified number fractions or treatment sessions over defined time) for has not been uniformly accepted, we examined whether 22-day was as effective more traditional 35-day reducing recurrence. Methods: Women with invasive cancer who were treated by and had pathologically clear...
Treatment with an aromatase inhibitor for 5 years as up-front monotherapy or after tamoxifen therapy is the treatment of choice hormone-receptor-positive early breast cancer in postmenopausal women. Extending to 10 may further reduce risk breast-cancer recurrence.
Background:Breast-conservation surgery is now commonly used to treat breast cancer. Postoperative irradiation reduces cancer recurrence in the breast. There still controversy concerning necessity of all patients.
Most women with breast cancer are diagnosed at an early stage and more than 80% will be long-term survivors. Routine follow-up marks the transition from intensive treatment to survivorship. It is usual practice for routine take place in specialist clinics. This study tested hypothesis that by patient's family physician a safe acceptable alternative follow-up.A multicenter, randomized, controlled trial was conducted involving 968 patients early-stage who had completed adjuvant treatment, were...