A5072416022- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Parathyroid Disorders and Treatments
- Cutaneous Melanoma Detection and Management
- Cancer Genomics and Diagnostics
- Glaucoma and retinal disorders
- Melanoma and MAPK Pathways
- Cancer-related Molecular Pathways
- Geographic Information Systems Studies
- Genetic Syndromes and Imprinting
- Breast Lesions and Carcinomas
- Thyroid Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Advanced Chemical Physics Studies
- Gene expression and cancer classification
- Retinal and Optic Conditions
- BRCA gene mutations in cancer
- Thyroid and Parathyroid Surgery
- Cancer Treatment and Pharmacology
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Spectroscopy and Quantum Chemical Studies
United States Air Force Academy
2023-2025
Washington University in St. Louis
1996-2024
Vanderbilt University
2024
University of Maryland, Baltimore
2014-2023
Duke Medical Center
2007-2023
AT Sciences (United States)
2023
University of Maryland Medical Center
2012-2022
NHS Grampian
2005-2022
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2020
Duke University
2002-2019
The recurrence score based on the 21-gene breast cancer assay predicts chemotherapy benefit if it is high and a low risk of in absence low; however, there uncertainty about for most patients, who have midrange score.We performed prospective trial involving 10,273 women with hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, axillary node-negative cancer. Of 9719 eligible patients follow-up information, 6711 (69%) had 11 to 25 were randomly assigned receive...
Prognostic and predictive factors are indispensable tools in the treatment of patients with neoplastic disease. For most part, such rely on a few specific cell surface, histological, or gross pathologic features. Gene expression assays have potential to supplement what were previously distinct features many thousands We developed Bayesian regression models that provide capability based gene data derived from DNA microarray analysis series primary breast cancer samples. These patterns...
Prior studies with the use of a prospective-retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, prospectively conducted study in uniformly treated population provides highest level evidence supporting clinical validity and usefulness biomarker.We performed prospective trial involving women hormone-receptor-positive, human epidermal growth factor receptor type 2 (HER2)-negative, axillary...
To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two studies neoadjuvant aromatase inhibitor therapy by massively parallel sequencing and analysis. Eighteen significantly mutated genes were identified, including five (RUNX1, CBFB, MYH9, MLL3 SF3B1) previously linked to haematopoietic disorders. Mutant MAP3K1 was associated luminal A status, low-grade histology...
Preoperative aromatase inhibitor (AI) treatment promotes breast-conserving surgery (BCS) for estrogen receptor (ER)-positive breast cancer. To study this option, responses to three AIs were compared in a randomized phase II neoadjuvant trial designed select agents III investigations.Three hundred seventy-seven postmenopausal women with clinical stage ER-positive (Allred score 6-8) cancer randomly assigned receive exemestane, letrozole, or anastrozole. The primary end point was response....
The use of adjuvant chemotherapy in patients with breast cancer may be guided by clinicopathological factors and a score based on 21-gene assay to determine the risk recurrence. Whether level clinical recurrence adds prognostic information is not known.
Screening programs using retinal photography for the detection of diabetic eye disease are being introduced in U.K. and elsewhere. Automatic grading images is considered by health boards so that human task reduced. Microaneurysms (MAs) earliest sign this very important classifying whether show signs retinopathy. This paper describes automatic methods MA shows how image contrast normalization can improve ability to distinguish between MAs other dots occur on retina. Various compared. Best...
Purpose To determine the pathologic complete response (pCR) rate in estrogen receptor (ER) –positive primary breast cancer triaged to chemotherapy when protein encoded by MKI67 gene (Ki67) level was > 10% after 2 4 weeks of neoadjuvant aromatase inhibitor (AI) therapy. A second objective examine risk relapse using Ki67-based Preoperative Endocrine Prognostic Index (PEPI). Methods The American College Surgeons Oncology Group (ACOSOG) Z1031A trial enrolled postmenopausal women with stage II...
Permanent hypoparathyroidism is a recognized complication of thyroidectomy. Operative strategies to prevent this include preservation parathyroid glands in situ and autotransplantation resected or devascularized during thyroidectomy.An analysis 194 patients having thyroidectomy simultaneous at Barnes Hospital from 1990 1994 was performed. Data were collected regarding patient demographics, indication for thyroidectomy, operative procedure, pathologic diagnoses, postoperative course,...
<h3>Aim:</h3> To assess the efficacy of automated “disease/no disease” grading for diabetic retinopathy within a systematic screening programme. <h3>Methods:</h3> Anonymised images were obtained from consecutive patients attending regional primary care based A training set 1067 was used to develop algorithms. The final software tested using separate 14 406 6722 patients. sensitivity and specificity manual systems operating as graders (detecting poor quality any retinopathy) determined...
Several phosphoinositide 3-kinase (PI3K) catalytic subunit inhibitors are currently in clinical trial. We therefore sought to examine relationships between pharmacologic inhibition and somatic mutations PI3K subunits estrogen receptor (ER)-positive breast cancer, which these particularly common. RNA interference (RNAi) was used determine the effect of selective subunits, p110alpha p110beta, ER(+) cancer cells harboring either mutation (PIK3CA) or gene amplification (PIK3CB). RNAi inhibited...
purpose. To evaluate the performance of an automated retinal image quality assessment system for use in diabetic retinopathy grading. methods. Algorithmic methods have been developed assessing 45° single field images screening. For this purpose, was defined by two aspects: clarity and definition. An with adequate as one that shows sufficient detail The visibility macular vessels used indicator clarity, since these are known to be narrow become less visible any degradation. definition desired...
Lesions of the occipital cortex result in areas cortical blindness affecting corresponding regions patient's visual field. The traditional view is that, aside from some spontaneous recovery first few months after damage, when acute effects have subsided are absolute and permanent. It has been found, however, that within such field defects residual capacities may persist absence acknowledged awareness by subject (blindsight type 1) or impaired (type 2). Neuronal pathways mediating blindsight...
In recent years, computer-based testing (CBT) has grown in popularity, is increasingly being implemented across the United States, and will likely become primary mode for delivering tests future. Although CBT offers many advantages over traditional paper-and-pencil testing, assessment experts, researchers, practitioners, users have expressed concern about comparability of scores between two test administration modes. To help provide an answer to this issue, a meta-analysis was conducted...
A high 21-gene recurrence score (RS) by breast cancer assay is prognostic for distant of early after local therapy and endocrine alone, chemotherapy benefit.To describe clinical outcomes women with a RS who received adjuvant plus in the TAILORx trial, population expected to have rate alone.In this secondary analysis data from multicenter randomized 1389 hormone receptor-positive, ERBB2-negative, axillary node-negative cancer, 26 100 were prospectively assigned receive addition therapy. The...
Proliferative diabetic retinopathy is a rare condition likely to lead severe visual impairment. It characterized by the development of abnormal new retinal vessels. We describe method for automatically detecting vessels on optic disc using photography. Vessel-like candidate segments are first detected based watershed lines and ridge strength measurement. Fifteen feature parameters, associated with shape, position, orientation, brightness, contrast line density calculated each segment. Based...
Black race is associated with worse outcomes in early breast cancer. We evaluated clinicopathologic characteristics, the 21-gene recurrence score (RS), treatment delivered, and clinical by ethnicity among women who participated Trial Assigning Individualized Options for Treatment.The association between (White, Black, Asian, other or unknown) (Hispanic vs non-Hispanic) was examined using proportional hazards models. All P values are 2-sided.Of 9719 eligible hormone receptor-positive,...
PURPOSE Cancer-related cognitive impairment (CRCI) is common during adjuvant chemotherapy and may persist. TAILORx provided a novel opportunity to prospectively assess patient-reported among women with early breast cancer who were randomly assigned chemoendocrine therapy (CT+E) versus endocrine alone (E), allowing us quantify the unique contribution of CRCI. METHODS Women 21-gene recurrence score 11 25 enrolled in TAILORX CT+E or E. Cognitive was assessed subgroup 552 evaluable using 37-item...
To develop evidence-based recommendations for safe, effective, and appropriate treatment of secondary (SHPT) tertiary (THPT) renal hyperparathyroidism.Hyperparathyroidism is common among patients with chronic kidney disease, end-stage transplant. The surgical management SHPT THPT nuanced requires a multidisciplinary approach. There are currently no clinical practice guidelines that address the THPT.Medical literature was reviewed from January 1, 1985 to present 2021 by panel 10 experts in...
SUMMARY Aims To develop a technique to detect microaneurysms automatically in 50° digital red‐free fundus photographs and evaluate its performance as tool for screening diabetic patients retinopathy. Methods Candidate are extracted, after the image has been modified remove variations background intensity, by algorithms that enhance small round features. Each microaneurysm candidate is then classified according intensity size application of set rules derived from training 102 images. Results...