A5006927014- Heart Rate Variability and Autonomic Control
- Cancer Treatment and Pharmacology
- Renal cell carcinoma treatment
- Ovarian cancer diagnosis and treatment
- Thermoregulation and physiological responses
- Pain Mechanisms and Treatments
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- Cancer-related cognitive impairment studies
- Cardiovascular Health and Disease Prevention
- Renal and related cancers
- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Climate Change and Health Impacts
- Pancreatic and Hepatic Oncology Research
- Chemotherapy-related skin toxicity
- Exercise and Physiological Responses
- Intraperitoneal and Appendiceal Malignancies
- Endometrial and Cervical Cancer Treatments
- Childhood Cancer Survivors' Quality of Life
- Cancer Immunotherapy and Biomarkers
- Botulinum Toxin and Related Neurological Disorders
- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- Cardiovascular Disease and Adiposity
The University of Texas at Austin
2014-2024
Chris O’Brien Lifehouse
2014-2024
Royal Prince Alfred Hospital
2010-2023
Australian and New Zealand Urogenital and Prostate Cancer Trials Group
2015-2023
Liverpool Hospital
2008-2022
Dana-Farber Cancer Institute
2022
Austin College
2019
UNSW Sydney
2006-2019
Committee on Publication Ethics
2019
Coyle Institute
2018
To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two studies neoadjuvant aromatase inhibitor therapy by massively parallel sequencing and analysis. Eighteen significantly mutated genes were identified, including five (RUNX1, CBFB, MYH9, MLL3 SF3B1) previously linked to haematopoietic disorders. Mutant MAP3K1 was associated luminal A status, low-grade histology...
To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retained high fidelity. However, at single-nucleotide level, variable numbers PDX-specific somatic events documented, although they only rarely functionally significant. Variant allele frequencies often preserved in PDXs, demonstrating that clonal...
Tumor necrosis factor alpha (TNF-alpha) may play a role in renal cell carcinoma (RCC). We performed two sequential phase II studies of infliximab, an anti-TNF-alpha monoclonal antibody, patients with immunotherapy-resistant or refractory RCC.Patients progressing after cytokine therapy were treated intravenous infliximab as follows: study 1 (19 patients), 5 mg/kg at weeks 0, 2, and 6, then every 8 weeks; 2 (18 10 4 weeks. Treatment continued until disease progression (PD). Response was...
Epithelial cell adhesion molecule (EpCAM)-targeted capture remains the most common isolation strategy for circulating tumor cells (CTCs). However, epithelial-to-mesenchymal transition (EMT) leads to decreased epithelial EpCAM expression affecting optimal CTC capture. In this study, we tested a cohort of ovarian cancer lines using flow cytometry identify N-cadherin as additional immunomagnetic surface target isolation. Combined targeting mesenchymal and enriched CTCs from advanced patient...
The aim of CATS (Cardiotoxicity Adjuvant Trastuzumab Study) was to prospectively assess clinical, biochemical, and genomic predictors trastuzumab-related cardiotoxicity (TRC). Cardiac dysfunction is a common adverse effect trastuzumab. Studies identify predictive biomarkers for TRC have enrolled heterogeneous populations yielded mixed results. A total 222 patients with early-stage human epidermal growth factor receptor 2–positive breast cancer scheduled receive adjuvant anthracyclines...
Importance Chemotherapy-induced peripheral neuropathy (CIPN) is a substantial adverse effect of anticancer treatments. As such, the assessment CIPN remains critically important in both research and clinic settings. Objective To compare validity various patient-reported outcome measures (PROMs) with neurophysiological sensory functional as optimal method assessment. Design, Setting, Participants This cohort study evaluated participants treated neurotoxic chemotherapy across 2 cohorts using...
Advancing age is a major risk factor for coronary artery disease. Endothelial dysfunction accompanied by increased oxidative stress and inflammation with aging may predispose older arteries to greater ischemia-reperfusion (I/R) injury. Because ischemia cannot be induced safely, the effects of habitual endurance exercise on endothelial I/R injury have not been determined in humans. Using brachial as surrogate model arteries, function, assessed flow-mediated dilation (FMD), was measured before...
The aim of this study was to determine the feasibility a combined supervised and home-based exercise intervention during chemotherapy for women with recurrent ovarian cancer. Secondary aims were impact physical activity on psychological outcomes completion rates.Women cancer recruited from 3 oncology outpatient clinics in Sydney Canberra, Australia. All participants received an individualized program that consisted 90 minutes or more low moderate aerobic, resistance, core stability, balance...
Paclitaxel treatment produces significant peripheral neuropathy, but the time course of neuropathy development and outcomes are unclear. Dose reduction is only strategy to prevent neurotoxicity, however, impact dose-reduction on remains unknown. This study aimed prospectively evaluated from weekly paclitaxel evaluate post-treatment outcomes.Breast cancer patients receiving (80mg/m2 ) for 12-weeks were assessed using patient reported (Functional Assessment Cancer Therapy/Gynecologic Oncology...
Background: Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common complication of cancer treatment that produces functional disability. Increasingly, patient-reported outcome measures (PROMs) are used to assess CIPN, providing broader symptom perspective than clinician-graded scales. Understanding when reported change in CIPN symptoms meets the threshold for clinical significance challenging. This study aimed provide interpretation guidelines validated PROMs, and thereby enable...
Abstract Clinical signs and symptoms of spasticity include hypertonia, involuntary movements (spasms, clonus), decreased range motion, contractures, often spasm‐related pain. When is refractory to medical management, patients may be referred for intrathecal baclofen (ITB) pump placement. We reviewed a cohort amyotrophic lateral sclerosis (ALS) with intractable requiring ITB further define the impact on pain relief in this patient population. From 2003 2005, eight (mean age 43.8 years; 5 men,...
Chemotherapy-induced peripheral neuropathy (CIPN) persists after treatment in up to 40% of cancer survivors and has been linked with increased balance deficits, disabilities, fall occurrences. This study aimed comprehensively assess the links between CIPN, functional disability inform development clinical screening tools for patients at risk these events.A total 190 exposed neurotoxic chemotherapies (age, 57 ± 13 years; average time from completion therapy, 12 11 months) attended a neurology...
Chemotherapy-induced peripheral neurotoxicity (CIPN) affects the quality of life cancer survivors. However, impact pain on symptom burden remains undefined. This study aimed to define differences in clinical profile patients with painful and nonpainful CIPN.
Flow-mediated dilation (FMD) is a surrogate marker for endothelial function. In the FMD procedure, arterial response during cuff inflation not taken into consideration yet studies have demonstrated vasoconstriction, vasodilation and no change in brachial artery inflation. The term low flow-mediated constriction (L-FMC) has been introduced to describe vasoconstriction that occurs some individuals of cuff. aims this study were examine (i) whether differed population with varied coronary...
BackgroundThe primary aim of this study was to evaluate the activity intraperitoneal bevacizumab (IP-bev) in delaying re-accumulation malignant ascites women with chemotherapy-resistant epithelial ovarian cancer (CR-EOC) who have ceased chemotherapy. Secondary outcomes were safety and quality life.MethodsWomen CR-EOC that reaccumulated within 28 days their last paracentesis (P-1) administered IP-bev 5 mg/kg following first therapeutic on (P0). Additional doses allowed at each subsequent (P1,...