A5048164891- Cancer Treatment and Pharmacology
- Chemotherapy-related skin toxicity
- Multiple Myeloma Research and Treatments
- Peripheral Neuropathies and Disorders
- Glioma Diagnosis and Treatment
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Cancer-related cognitive impairment studies
- Hereditary Neurological Disorders
- Myasthenia Gravis and Thymoma
- Pain Mechanisms and Treatments
- Colorectal Cancer Treatments and Studies
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neuroblastoma Research and Treatments
- Ion channel regulation and function
- Plant-based Medicinal Research
- Neuroscience and Neural Engineering
- Brain Metastases and Treatment
- Ocular Surface and Contact Lens
- Neurological disorders and treatments
- Glaucoma and retinal disorders
- Parkinson's Disease and Spinal Disorders
- Muscle activation and electromyography studies
- Nerve injury and regeneration
The University of Sydney
2016-2025
UNSW Sydney
2011-2025
Chris O’Brien Lifehouse
2024
Maastricht University
2021
Johns Hopkins University
2021
University of Milano-Bicocca
2021
Cooperative Trials Group for Neuro-Oncology
2020
Royal Prince Alfred Hospital
2018-2019
National Health and Medical Research Council
2019
Westmead Hospital
2019
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a debilitating adverse effect of cancer treatment. Current understanding the mechanisms underpinning CIPN limited there are no effective treatment strategies. In this study, we treated male C57BL/6J mice with 4 cycles either Paclitaxel (PTX) or Oxaliplatin (OXA) over week tested hypersensitivity changes in immune responses neuroinflammation on days 7 13 post 1st injection. We found that both PTX OXA caused...
Administration of oxaliplatin, a platinum-based chemotherapy used extensively in the treatment colorectal cancer, is complicated by prominent dose-limiting neurotoxicity. Acute neurotoxicity develops following oxaliplatin infusion and resolves within days, while chronic neuropathy progressively with higher cumulative doses. To investigate pathophysiology oxaliplatin-induced neuropathy, clinical grading scales, nerve conduction studies total 905 axonal excitability were undertaken cohort 58...
Acetylcholine (ACh) is a neurotransmitter critical for normal cognition. Here we demonstrate heterogeneity of cholinergic signaling in neocortical neurons the rat prefrontal, somatosensory, and visual cortex. Focal ACh application (100 muM) inhibited layer 5 pyramidal all cortical areas via activation an apamin-sensitive SK-type calcium-activated potassium conductance. Cholinergic inhibition was most robust prefrontal neurons, where it relies on same signal transduction mechanism (M1-like...
Abstract Learning Objectives After completing this course, the reader will be able to: Define symptoms of sensory neurotoxicity in oxaliplatin-treated patients and identify long-term natural history nerve dysfunction as a long-lasting complication treatment that does not necessarily resolve within 6 months.Use excitability techniques to predict long-standing changes function produced by oxaliplatin. CME This article is available for continuing medical education credit at...
Purpose Neurotoxicity is becoming increasingly recognized as the major dose-limiting toxicity of oxaliplatin. Because mechanism oxaliplatin-induced neurotoxicity remains unclear, present study investigated potential axonal excitability techniques in identifying pathophysiologic mechanisms and early markers nerve dysfunction. Patients Methods Measures sensory were recorded before after infusion over 88 treatment cycles 25 patients with colorectal cancer, who received a total oxaliplatin dose...
To study the relationship between cortical function and survival in amyotrophic lateral sclerosis (ALS).A total of 216 referrals were screened, participants with familial ALS or an inexcitable cortex excluded. Clinical measures phenotyping from 169 patients sporadic combined assessment using threshold tracking transcranial magnetic stimulation indices including short interval intracortical inhibition (SICI). Peripheral nerve studies collected, incorporating compound muscle action potential...
In light of the excellent long-term survival childhood cancer patients, it is imperative to screen for factors affecting health, function, and quality life in survivors.To comprehensively assess chemotherapy-induced peripheral neuropathy survivors define disease burden functional effect inform screening recommendations.In this cross-sectional observational study, who were treated with chemotherapy extracranial malignancy before age 17 years recruited consecutively between April 2015 December...
<h3>Importance</h3> Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating adverse effect of neurotoxic cancer treatments including taxanes and platinum agents. Limited knowledge exists potential prechemotherapy factors associated with CIPN development. <h3>Objective</h3> To identify the association pretreatment blood-based clinical persistence in patients who received paclitaxel or oxaliplatin. <h3>Design, Setting, Participants</h3> This cohort study assessed demographic...
Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major adverse effect of cancer treatment. However, its impact remains poorly understood. This study aimed to investigate the associated with CIPN on lives survivors.A volunteer sample 986 individuals who had received neurotoxic chemotherapy completed an anonymous, cross-sectional survey. Outcomes assessed included symptoms, pain, neuropathic quality life (QoL), physical activity, and comorbid health conditions via Self-Administered...