A5038200816- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Alcoholism and Thiamine Deficiency
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Neurological and metabolic disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurological diseases and metabolism
- Alcohol Consumption and Health Effects
- Advanced Neuroimaging Techniques and Applications
- Infectious Encephalopathies and Encephalitis
- Memory and Neural Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Neurogenetic and Muscular Disorders Research
- Cholinesterase and Neurodegenerative Diseases
- S100 Proteins and Annexins
- Neurological Disease Mechanisms and Treatments
- Neurobiology of Language and Bilingualism
- Diet and metabolism studies
- Neurological disorders and treatments
- Prion Diseases and Protein Misfolding
- Prenatal Substance Exposure Effects
- Peroxisome Proliferator-Activated Receptors
The University of Sydney
2015-2024
Macquarie University
2021-2024
UNSW Sydney
2003-2019
Neuroscience Research Australia
1997-2019
Royal Prince Alfred Hospital
1990-2019
Garvan Institute of Medical Research
2019
St Vincent's Clinic
2016-2019
ARC Centre of Excellence in Cognition and its Disorders
2019
Sahlgrenska University Hospital
2017
University of Ottawa
2017
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration : an update
The term frontotemporal dementia (FTD) encompasses a range of clinical syndromes that are believed not to map reliably onto the spectrum recognized pathologies. This study reexamines relationships between and pathological subtypes FTD in large series from two centers (n = 61). Clinical defined were behavioral variant 26), language variants (semantic dementia, n 9; progressive nonfluent aphasia, 8), motor (corticobasal degeneration, neuron disease, 9), although most cases presented with...
To establish better operational criteria for the diagnosis of Wernicke's encephalopathy. Current diagnosing encephalopathy require presence three clinical signs (oculomotor abnormalities, cerebellar dysfunction, and an altered mental state), although it has often been reported that most patients do not fulfil all these criteria.The histories 28 alcoholics with neurological neuropsychological assessments definitive neuropathological diagnoses were examined to determine use in a screening...
To establish survival in patients with pathologically confirmed frontotemporal dementia (FTD) and to determine whether clinical or pathologic subtype affects prognosis.The authors reviewed the presenting features of 61 FTD studied Sydney (n = 31) Cambridge 30) over a 10-year period. Data were available on time symptom onset, diagnosis, institutionalization, death. Cases classified as tau-positive tau-negative.Of FTD, 26 presented frontal variant (fvFTD), 9 semantic dementia, 8 progressive...
<b>Objective: </b> White matter hyperintensities (WMH) are commonly seen on neuroimaging scans, but their underlying histopathologic substrate is unclear. The aim of this work was to establish the pathologic correlates WMH in unselected elderly cases using two study designs. To avoid potential bias from comparisons different anatomic regions, 1 compared, region-by-region, severity determined vivo with measures each major white (WM) components. Study 2 compared histopathology normal WM....
Abstract Introduction Progress in understanding and management of vascular cognitive impairment (VCI) has been hampered by lack consensus on diagnosis, reflecting the use multiple different assessment protocols. A large multinational group clinicians researchers participated a two‐phase Vascular Impairment Cognition Classification Consensus Study (VICCCS) to agree principles (VICCCS‐1) protocols (VICCCS‐2) for diagnosis VCI. We present VICCCS‐2. Methods used VICCCS‐1 published diagnostic...
Alzheimer's disease (AD) brains are characterized by amyloid-β-containing plaques and hyperphosphorylated tau-containing neurofibrillary tangles (NFTs); however, in frontotemporal dementia, the tau pathology manifests absence of overt amyloid-β plaques. Therapeutic strategies so far have primarily been targeting amyloid-β, although those only slowly beginning to emerge. Here, we identify sodium selenate as a compound that reduces phosphorylation both vitro vivo. Importantly, chronic oral...
Amyloid-β (Aβ) toxicity in Alzheimer's disease (AD) is considered to be mediated by phosphorylated tau protein. In contrast, we found that, at least early disease, site-specific phosphorylation of inhibited Aβ toxicity. This specific was the neuronal p38 mitogen-activated protein kinase p38γ and interfered with postsynaptic excitotoxic signaling complexes engaged Aβ. Accordingly, depletion exacerbated circuit aberrations, cognitive deficits, premature lethality a mouse model AD, whereas...
Neurogenesis in the postnatal human brain occurs two neurogenic niches; subventricular zone (SVZ) wall of lateral ventricles and subgranular (SGZ) hippocampus. The extent to which this physiological process continues into adulthood is an area ongoing research. This study aimed characterize markers cell proliferation assess efficacy antibodies used identify neurogenesis both niches brain.
<h3>Objective</h3> To assess the impact of new clinical diagnostic criteria for frontotemporal dementia (FTD) syndromes, including primary progressive aphasias (PPA), on prior diagnosis and to explore clinicopathological correlations. <h3>Methods</h3> 178 consecutive neuropathologically ascertained cases initially diagnosed with a FTD syndrome were collected through specialist programmes: Cambridge Brain Bank, UK, Sydney Australia. 135 reclassified using revised into behavioural variant...
Abstract Introduction Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none been universally accepted. These not readily comparable, impacting on rates turn prevalence estimates, research, treatment. Methods The Vascular Impairment Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries an online Delphi consensus study....
Semantic dementia is a syndrome of progressive deterioration in semantic memory (knowledge objects, people, concepts and words). It falls within the clinical spectrum frontotemporal but its pathology yet to be studied systematically. This study included 18 consecutive post mortem cases meeting criteria for dementia. Clinic records diagnostic histopathology were available all cases; structural neuroimaging, neuropsychology semi-quantitative histopathology/immunohistochemistry data analysed...
Many studies have demonstrated significant sexual dimorphism in verbal ability. However, few examined anatomical differences between the sexes that may underlie such dimorphism.To examine sex absolute and proportional volumes of main language-associated regions cerebral cortex.Control neuropathological case series consecutive autopsies from a teaching hospital. No age-related volume changes were identified sample. Two cortical regions, superior temporal gyrus (part Wernicke area) its...
To devise a staging scheme for addressing the severity of atrophy in patients with pathologically proven frontotemporal dementia (FTD) and determine any relationship clinical indices.Twenty-four cases pathologic features FTD were selected using standard inclusion exclusion criteria from 125 collected Sydney, Australia, over an 8.5-year period. Patterns gross determined two coronal brain slices. Reproducibility four-stage was tested. Nonparametric statistics used to relationships between...
Abstract Maps of cytoarchitectonically defined cortical areas have proven to be a valuable tool for anatomic localization activated brain regions revealed by functional imaging studies. However, architectonic data require observations in sample postmortem brains. They can only used reliably comparison with as probabilistic maps after spatial normalization common reference space. The complete analysis an individual living has not been achievable date, because the relationship remains unclear...
Through an international consortium, we have collected 37 tau- and TAR DNA-binding protein 43 (TDP-43)-negative frontotemporal lobar degeneration (FTLD) cases, present here the first comprehensive analysis of these cases in terms neuropathology, genetics, demographics clinical data. 92% (34/37) had fused sarcoma (FUS) pathology, indicating that FTLD-FUS is important FTLD subtype. This collection specifically focussed on aFTLD-U one three recently defined subtypes FTLD-FUS. The subtype...