A5025174142- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- Alzheimer's disease research and treatments
- Developmental and Educational Neuropsychology
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Hemispheric Asymmetry in Neuroscience
- Health, Environment, Cognitive Aging
- Neurological disorders and treatments
- Neural and Behavioral Psychology Studies
- Multiple Sclerosis Research Studies
- Genetic Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Cerebrovascular and Carotid Artery Diseases
- Aging, Health, and Disability
- Cognitive Functions and Memory
- Psychological Treatments and Disorders
- Health, Education, and Physical Culture
- Ginkgo biloba and Cashew Applications
- Diet and metabolism studies
- Fetal and Pediatric Neurological Disorders
- Acute Ischemic Stroke Management
- Cardiac pacing and defibrillation studies
Universidad Fernando Pessoa Canarias
2022-2025
Universidad de La Laguna
2014-2023
Karolinska Institutet
2020
University of Bristol
2016-2017
University of Cambridge
2016
University of Toronto
2016
Sunnybrook Health Science Centre
2016
National University of Singapore
2016
Southmead Hospital
2016
Abstract Introduction Progress in understanding and management of vascular cognitive impairment (VCI) has been hampered by lack consensus on diagnosis, reflecting the use multiple different assessment protocols. A large multinational group clinicians researchers participated a two‐phase Vascular Impairment Cognition Classification Consensus Study (VICCCS) to agree principles (VICCCS‐1) protocols (VICCCS‐2) for diagnosis VCI. We present VICCCS‐2. Methods used VICCCS‐1 published diagnostic...
Abstract Introduction Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none been universally accepted. These not readily comparable, impacting on rates turn prevalence estimates, research, treatment. Methods The Vascular Impairment Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries an online Delphi consensus study....
Abstract Atrophy patterns on MRI can reliably predict three neuropathological subtypes of Alzheimer’s disease (AD): typical, limbic-predominant, or hippocampal-sparing. A method to enable their investigation in the clinical routine is still lacking. We aimed (1) validate combined use visual rating scales for identification AD subtypes; (2) characterise these at baseline and over two years; (3) investigate how atrophy non-memory cognitive domains contribute memory impairment. patients were...
Introduction In the last few years, several models trying to calculate biological brain age have been proposed based on structural magnetic resonance imaging scans (T1-weighted MRIs, T1w) using multivariate methods and machine learning. We developed validated a convolutional neural network (CNN)-based prediction model that uses one T1w MRI preprocessing step when applying external datasets simplify implementation increase accessibility in research settings. Our only requires rigid image...
The integrity of the cholinergic system plays a central role in cognitive decline both normal aging and neurological disorders including Alzheimer's disease vascular impairment. Most previous neuroimaging research has focused on basal forebrain, or its sub-region nucleus basalis Meynert (NBM). Tractography using diffusion tensor imaging data may enable modelling NBM white matter projections. We investigated contribution volume, projections, small vessel (SVD), age to performance attention...
Objective: Increased variability in cognition with age has been argued as an indication of pathological processes. Focusing on early detection neurodegenerative disorders, we investigated healthy middle-aged adults. In order to understand possible determinants this variability, also associations cognitive reserve, neuroimaging markers, subjective memory complaints, depressive symptomatology, and gender. Method: Thirty-one 50 ± 2 years old individuals were target group deviation was studied...
Introduction: Mild cognitive impairment is common in nondemented Parkinson disease patients (PD-MCI) and considered as a risk factor for dementia (PDD). Recently, the Movement Disorder Society (MDS) published guidelines PD-MCI, although studies available are still limited. The aim of this work was to characterize PD-MCI its progression dementia. Moreover, study variables could be predictors impairment. Method: included 43 with idiopathic PD (mean age = 59.19 years, SD 9.64) 20 healthy...
To define the profile of age-related differences in cognition healthy middle-aged adults order to identify most sensitive measures early cognitive decline. study whether these precede decline elderly.141 cognitively normal participants (101 with age 40-50±2; and 40 elderly individuals 65±2) were assessed a comprehensive neuropsychological protocol covering processing speed, attention, executive functions, verbal visual episodic memory, procedural visuoconstructive,...
Abstract Cognition plays a central role in the diagnosis and characterization of dementia with Lewy bodies (DLB). However, complex associations among cognitive deficits different domains DLB are largely unknown. To characterize these associations, we investigated compared connectome patients, healthy controls (HC), Alzheimer’s disease patients (AD). We obtained data from National Coordinating Center. built connectomes for ( n = 104), HC 3703), AD 1985) using correlations 24 measures mapping...
To investigate the neuropsychological profile in first few years post-onset of relapsing-remitting multiple sclerosis (MS) we carried out a comprehensive evaluation 33 patients characterized by very short evolution this disease, minimal levels neurological disability and preserved general cognition. Thirty-three individually pair-matched controls were also evaluated. Patients performed as well on many cognitive exploration measures. Nevertheless, group evinced slowness that affected motor...
Background and purpose: We have studied the relationship between neuropsychological impairment magnetic resonance imaging (MRI) measures in mildly disabling relapsing–remitting multiple sclerosis (RRMS). Methods: compared of lesion burden atrophy 52 patients with Expanded Disability Status Scale ≤ 3.0. Neuropsychological testing explored various cognitive domains: attention processing speed (APS), verbal visual memory (VerbM; VisM), visual/constructional processes (VC), executive functions...
Subjective cognitive complaints in cognitively normal individuals are a relevant predictor of Alzheimer's disease (AD), cerebrovascular disease, and age-related tauopathy. Complaints starting after the age 60 increase likelihood preclinical AD. However, this criterion is arbitrary current data show that neurodegenerative disorders likely start before age. Further, on role subjective below qualifying for decline (SCD) lacking. We investigated association with an extensive number neuroimaging,...
Verbal fluency has been widely studied in cognitive aging.However, compensatory mechanisms that maintain its optimal performance with increasing age are not completely understood.Using cross-sectional data, we investigated differentiation and dedifferentiation processes verbal across the lifespan by analyzing association between numerous measures within four groups (N=446): early middle-age (32-45 years), late (46-58 elderly (59-71 (72-84 years).ANCOVA was used to investigate interaction...
Recently, we reported that practice facilitates the expression of behavioral asymmetry in rats at individual and population levels. In present study investigated side preference performance four different tasks during 10 successive days. The increased laterality internal consistency all tasks. addition, facilitated marked two (78.1% 63.3% for right bias). influence dopaminergic systems on these behaviors was evaluated with apomorphine 6-hydroxydopamine lesions ipsi- contralateral to...
Abstract Subjective cognitive decline (SCD) has been proposed as a risk factor for future and dementia. Given the heterogeneity of SCD lack consensus about how to classify this condition, different operationalization approaches still need be compared. In study, we used same sample individuals compare approaches. We included 399 cognitively healthy from community-based cohort. was assessed through nine questions memory non-memory subjective complaints. applied four operationalize SCD: two...
Objectives : Cognitive aging has been extensively investigated using both univariate and multivariate analyses. Sophisticated approaches such as graph theory could potentially capture unknown complex associations between multiple cognitive variables. The aim of this study was to assess whether cognition is organized into a structure that be called the “cognitive connectome,” connectome differs age groups. Methods A total 334 cognitively unimpaired individuals were stratified early-middle-age...
Abstract Background Age‐related cognitive decline is linked to changes in the brain, particularly deterioration of white matter (WM) microstructure that accelerates after age 60. WM associated with mild impairment and dementia, but origin role signal abnormalities (WMSA) seen standard MRI remain debated due their heterogeneity. This study explores potential single‐shell 3‐tissue constrained spherical deconvolution (SS3T‐CSD), a novel technique models diffusion data terms gray (T G ), w...
During ageing, different cognitive functions decline at rates. Additionally, reserve may influence inter-individual variability in age-related decline. These complex relationships can be studied by constructing a so-called connectome and characterising it with advanced graph-theoretical network analyses. This study examined the effect of on across age. A total 334 cognitively healthy participants were stratified into early middle age (37-50 years; n = 110), late (51-64 106), elderly (65-78...
Although recognized as one of the most common hereditary diseases nervous system, neuropsychological deficits in Friedreich's ataxia (FA) have rarely been studied. A protocol was constructed to assess major cognitive areas patients with FA and pair-matched normal controls. Motor difficulties, dysarthria fatigability were taken into account. Neuropsychological assessment showed decreased motor mental reaction times, reduced verbal span, letter fluency, impaired acquisition consolidation...
This study examined phonemic (letters), semantic (animals) and action verbal fluency cues in twenty-four patients with FRDA, twenty matched healthy control subjects. The Action Fluency Test (AFT) is a newly-developed cue that consists asking the subject to rapidly generate verbs. Given high presence of dysarthria cognitive slowness FRDA patients, tasks were administered order dissociate motor/articulatory impairment from deficit. Results showed subjects performed similarly on task. In...