A5072184341- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Cancer Treatment and Pharmacology
- Childhood Cancer Survivors' Quality of Life
- Antibiotic Resistance in Bacteria
- Head and Neck Cancer Studies
- Diet and metabolism studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pain Management and Opioid Use
- Cancer-related cognitive impairment studies
- Pharmacological Effects and Toxicity Studies
- Family and Patient Care in Intensive Care Units
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Genomics and Diagnostics
- Blood disorders and treatments
- Neuropeptides and Animal Physiology
- Chronic Kidney Disease and Diabetes
- Chemotherapy-related skin toxicity
- Alzheimer's disease research and treatments
University Medical Center Utrecht
2019-2022
Radboud University Nijmegen
1986-2018
Radboud University Medical Center
2002-2018
Karolinska Institutet
2017
Pain and Rehabilitation Medicine
2011-2017
Sanquin
2007-2008
Abstract Atrophy patterns on MRI can reliably predict three neuropathological subtypes of Alzheimer’s disease (AD): typical, limbic-predominant, or hippocampal-sparing. A method to enable their investigation in the clinical routine is still lacking. We aimed (1) validate combined use visual rating scales for identification AD subtypes; (2) characterise these at baseline and over two years; (3) investigate how atrophy non-memory cognitive domains contribute memory impairment. patients were...
OBJECTIVE Type 2 diabetes is associated with cognitive dysfunction and an increased dementia risk, particularly in individuals concomitant cardiovascular and/or kidney disease. Incretin therapies may modulate this risk via glycemic nonglycemic pathways. We explored if the dipeptidyl peptidase 4 inhibitor linagliptin could prevent decline people type cardiorenal RESEARCH DESIGN AND METHODS The CArdiovascular Renal Microvascular outcomE study LINAgliptin (CARMELINA)-COG substudy was integral...
Abstract Aims/hypothesis Type 2 diabetes, particularly with concomitant CVD, is associated an increased risk of cognitive impairment. We assessed the effect on accelerated decline (ACD) DPP-4 inhibitor linagliptin vs sulfonylurea glimepiride in individuals type diabetes. Methods The CAROLINA-COGNITION study was part randomised, double-blind, active-controlled CAROLINA trial that evaluated cardiovascular safety age ≥40 and ≤85 years HbA 1c 48–69 mmol/mol (6.5–8.5%) receiving standard care,...
Background and aim: Patients with advanced chronic obstructive pulmonary disease (COPD) have poor quality of life. The aim this study was to assess the effects proactive palliative care on well-being these patients. Trial registration: This trial is registered Netherlands Register, NTR4037. methods: A pragmatic cluster controlled (quasi-experimental design) performed hospitals as (three intervention three control) a pretrial assessment performed. Hospitals were selected for group based...
Introduction: Early palliative care is not a common practice for patients with COPD. Important barriers are the identification of and organization such in this patient group. Objective: Pulmonologists have central role providing good quality To guide future research develop services, their view on these was explored. Methods: A survey study performed by members Netherlands Association Physicians Lung Diseases Tuberculosis. Results: The 256 respondents (31.8%) covered 85.9% hospital...
Cognitive dysfunction is increasingly recognized as an important comorbidity of type 2 diabetes (T2D). We aimed to establish if the risk accelerated cognitive decline (ACD) higher in females with T2D than males.3163 participants (38% female) from cognition substudy CAROLINA® (NCT01243424) were included (mean age 64.4 ± 9.2 years; duration 7.6 6.1 years). The outcome was occurrence ACD at end follow-up, defined a regression based index score ≤16th percentile on either Mini-Mental State...
In our aging society, palliative care should be a standard component of health care. However, currently it is only provided to small proportion patients, mostly those with cancer, and restricted the terminal phase. Many general practitioners (GPs) say that one their most significant challenges assess right moment start anticipatory The "Surprise Question" (SQ1: "Would I surprised if this patient were die in next 12 months"?), answered "no", an easy tool apply identifying patients need has...
In a prospective randomized study, ceftazidime monotherapy was compared with combination of plus cephalothin in 102 febrile neutropenic patients. Thirty bacteriologically documented infections, which 23 were bacteremias, 48 clinically assessable patients treated alone. Twenty-four proven 18 42 and cephalothin. The clinical response rates 77% for 88% the combination. bacteriological clearance rate 70% 79% Efficacy against gram-negative pathogens appeared to be excellent, 93% 100%...
Allografts of bone from the femoral head are often used in orthopaedic procedures. Although donated heads thoroughly tested microscopically before release by bank, some surgeons take additional cultures operating theatre implantation. There is no consensus about need to these cultures. We retrospectively assessed clinical significance implantation positive-cultured allografts. The contamination rate at retrieval allografts was 6.4% our bank. Intra-operative were taken 426 implantation; 48...
Journal Article Teicoplanin as modification of initial empirical therapy in febrile granulocytopenic patients Get access Irena R. O. Nováková, Nováková Department Internal Medicine, Division Haematology and Institute Medical Microbiology, Bacteriology, University HospitalNijmegen, The Netherlands Corresponding author: Dr Haematology, Hospital, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, Netherlands. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Peter...
The incidence of drug‐induced skin rashes and related factors were analysed in a retrospective study 151 patients with acute non‐lymphocytic leukaemia (ANLL). 91 (60%) developed drug‐related toxicodermia to one or more drugs during remission, induction maintenance therapy. was mainly confined the blastic stage occurred significantly less often remission. Patients myeloid leukaemia, FAB classification M1, M2 M3 (M1‐3) reactions than those types M4 M5 (M4‐5). Women suffered frequently from...
To investigate the relationship between diabetes-specific dementia risk score (DSDRS) and concurrent future cognitive impairment (CI) in type 2 diabetes (T2D).DSDRS were calculated for participants with T2D aged ≥60 years from CARMELINA-cognition substudy (ClinicalTrials.gov Identifier: NCT01897532). Cognitive assessment included Mini-Mental State Examination (MMSE) a composite attention executive functioning (A&E). The relation baseline DSDRS probability of CI (MMSE < 24) variation...
We addressed the question whether chronic kidney disease (CKD) may contribute to cognitive decline in type 2 diabetes. Participants with diabetes elevated cardiovascular risk or CKD from cognition substudies of two large trials were studied prospectively (CARMELINA: n = 2666, mean ± SD age 68.1 8.7 years, CAROLINA: 4296; 64.7 9.4 years). Estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) at baseline related performance (Mini-Mental State Examination...
a more consistent use of these guidelines.