A5044517920- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- PARP inhibition in cancer therapy
- Gastrointestinal Tumor Research and Treatment
- Cell death mechanisms and regulation
- Advanced Radiotherapy Techniques
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Lipid Membrane Structure and Behavior
- Head and Neck Cancer Studies
- Sphingolipid Metabolism and Signaling
- Effects of Radiation Exposure
- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Colorectal and Anal Carcinomas
- Medical Imaging Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
Radboud University Nijmegen
1998-2025
Radboud University Medical Center
2018-2025
The Netherlands Cancer Institute
2015-2024
Exosome Diagnostics (United States)
2024
University Medical Center
2019-2024
Hôpital Orthopédique de la Suisse Romande
2018
Heidelberger Institut für Radioonkologie
2018
TU Dresden
2016
University of Lausanne
2016
Oncode Institute
1995-2016
Most new radiation techniques, have been introduced primarily to reduce the dose normal tissues in order prevent radiation-induced side effects. Radiotherapy with protons is such a technique that due its superior beam properties compared photons enables better sparing of tissues. This paper describes stepwise methodology select patients for proton therapy when primary aim method has accepted by Dutch health authorities therapy. In addition, an alternative described case randomised controlled...
Abstract Liquid biopsies are providing new opportunities for detection of residual disease in cell-free DNA (cfDNA) after surgery but may be confounded through identification alterations arising from clonal hematopoiesis. Here, we identify circulating tumor-derived (ctDNA) ultrasensitive targeted sequencing analyses matched cfDNA and white blood cells the same patient. We apply this approach to analyze samples patients CRITICS trial, a phase III randomized controlled study perioperative...
The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to provide clinical practice guidelines for the definition, diagnosis, and treatment of esophagogastric oligometastatic disease (OMD).
Synthetic alkyl-lysophospholipids (ALPs) represent a new class of anti-tumor agents that target cell membranes and induce apoptosis. However, the exact mechanisms by which ALPs exert these effects remain unclear. Here, we investigated in epithelial carcinoma lines A431 HeLa effect three clinically relevant [Et-18-OCH3 (Edelfosine), HePC (Miltefosine) D-21266 (Perifosine)] on phosphatidylinositol 3-kinase (PI3K)-Akt/PKB survival pathway. We found growth factor-induced Akt/PKB activation cells...
The Intergroup 0116 trial has demonstrated that postoperative chemoradiotherapy (CRT) improves survival in gastric cancer. We retrospectively compared and recurrence patterns two phase I/II studies evaluating more intensified CRT with those from the Dutch Gastric Cancer Group Trial (DGCT) randomly assigned patients between D1 D2 lymphadenectomy.Survival of 91 adenocarcinoma stomach who had received surgery followed by radiotherapy combined fluorouracil leucovorin (n = 5), capecitabine 39),...
Abstract Background Radical surgery is the cornerstone in treatment of resectable gastric cancer. The Intergroup 0116 and MAGIC trials have shown benefit postoperative chemoradiation perioperative chemotherapy, respectively. Since these cannot be compared directly, both regimens are evaluated prospectively CRITICS trial. This study aims to obtain an improved overall survival for patients treated with preoperative chemotherapy by incorporating radiotherapy concurrently postoperatively....
Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperative chemotherapy, postoperative chemoradiotherapy and chemotherapy. However, these regimens suffer from poor patient compliance, particularly phase treatment. The CRITICS-II trial aims optimize preoperative treatment by comparing three regimens: (1) (2) chemotherapy followed (3)...
An international research consortium has been formed to facilitate evidence-based introduction of MR-guided radiotherapy (MR-linac) and address how the MR-linac could be used achieve an optimized radiation treatment approach improve patients' survival, local regional tumor control, quality life. The present paper describes organizational structure clinical part consortium. Furthermore, it elucidates why collaboration on this large project is necessary a central data registry program will implemented.