Harm van Tinteren
A5031176507- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Colorectal Cancer Treatments and Studies
- Breast Cancer Treatment Studies
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Advanced Breast Cancer Therapies
- Childhood Cancer Survivors' Quality of Life
- Brain Metastases and Treatment
- CAR-T cell therapy research
- Urological Disorders and Treatments
- Head and Neck Cancer Studies
- Genital Health and Disease
Princess Máxima Center
2021-2025
Wilhelmina Children's Hospital
2025
The Netherlands Cancer Institute
2014-2024
Oncode Institute
2005-2021
American Association For Cancer Research
2021
Dutch Cancer Society
1992-2020
University of Groningen
2005-2019
Erasmus MC
2006-2018
Radboud University Medical Center
2005-2018
Radboud University Nijmegen
2005-2018
To confirm the findings from uncontrolled studies that aggressive cytoreduction in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) is superior to standard treatment patients peritoneal carcinomatosis of colorectal cancer origin.Between February 1998 and August 2001, 105 were randomly assigned receive either consisting systemic (fluorouracil-leucovorin) or without palliative surgery, experimental therapy HIPEC, followed by same regime. The primary end point was...
The AACR Project GENIE is an international data-sharing consortium focused on generating evidence base for precision cancer medicine by integrating clinical-grade genomic data with clinical outcome tens of thousands patients treated at multiple institutions worldwide. In conjunction the first public release from approximately 19,000 samples, we describe goals, structure, and standards report conclusions high-level analysis initial phase data. We also provide examples utility data, such as...
Treatment of newly diagnosed advanced-stage ovarian cancer typically involves cytoreductive surgery and systemic chemotherapy. We conducted a trial to investigate whether the addition hyperthermic intraperitoneal chemotherapy (HIPEC) interval would improve outcomes among patients who were receiving neoadjuvant for stage III epithelial cancer.In multicenter, open-label, phase 3 trial, we randomly assigned 245 had at least stable disease after three cycles carboplatin (area under curve 5 6 mg...
BackgroundMost patients with extensive stage small-cell lung cancer (ES-SCLC) who undergo chemotherapy, and prophylactic cranial irradiation, have persistent intrathoracic disease. We assessed thoracic radiotherapy for treatment of this patient group.MethodsWe did phase 3 randomised controlled trial at 42 hospitals: 16 in Netherlands, 22 the UK, three Norway, one Belgium. enrolled WHO performance score 0–2 confirmed ES-SCLC responded to chemotherapy. They were randomly assigned (1:1) receive...
In Brief Objective: The MARI procedure [marking the axillary lymph node with radioactive iodine (125I) seeds] is a new minimal invasive method to assess pathological response of nodal metastases after neoadjuvant systemic treatment (NST) in patients breast cancer. This allows axilla-conserving surgery responding well NST. Methods: Prior NST, proven tumor-positive nodes were marked 125I seed. so-called MARI-node. After was selectively removed using γ-detection probe. A complementary...
Immune checkpoint inhibitors and targeted therapies have dramatically improved outcomes in patients with advanced melanoma, but approximately half these will not a durable benefit. Phase 1-2 trials of adoptive cell therapy tumor-infiltrating lymphocytes (TILs) shown promising responses, data from phase 3 are lacking to determine the role TILs treating melanoma.In this 3, multicenter, open-label trial, we randomly assigned unresectable stage IIIC or IV melanoma 1:1 ratio receive TIL...
The 70-gene signature (MammaPrint™) has been developed on retrospective series of breast cancer patients to predict the risk distant metastases. microarRAy-prognoSTics-in-breast-cancER (RASTER) study was first designed prospectively evaluate performance signature, which result available for 427 (cT1-3N0M0). Adjuvant systemic treatment decisions were based Dutch CBO 2004 guidelines, and doctors' patients' preferences. Five-year distant-recurrence-free-interval (DRFI) probabilities compared...
BackgroundBefore this study started, the standard postoperative chemotherapy regimen for stage II–III Wilms' tumour pretreated with was to include doxorubicin. However, avoidance of doxorubicin-related cardiotoxicity effects is important improve long-term outcomes childhood cancers that have excellent prognosis. We aimed assess whether doxorubicin can be omitted safely from II–III, histological intermediate-risk when a newly defined high-risk blastemal subtype excluded...
Objective: To assess long-term results with consistent use of indwelling voice