A5103033750- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Drug Transport and Resistance Mechanisms
- IgG4-Related and Inflammatory Diseases
- Photodynamic Therapy Research Studies
- Gastrointestinal disorders and treatments
- Liver Diseases and Immunity
- Viral-associated cancers and disorders
- Pancreatitis Pathology and Treatment
- Oral and Maxillofacial Pathology
- Lung Cancer Treatments and Mutations
- Innovations in Medical Education
- Renal cell carcinoma treatment
Amsterdam University Medical Centers
2019-2025
University of Amsterdam
2014-2025
Cancer Center Amsterdam
2018-2023
Vrije Universiteit Amsterdam
2023
Amsterdam UMC Location University of Amsterdam
2012-2022
Reinier de Graaf Hospital
2018
University Medical Center
2018
Hôpital Antoine-Béclère
2017
Laboratoire d'études sur les monothéismes
2017
Toulon Var Technologies (France)
2017
The European Guidelines Meeting on Laparoscopic Liver Surgery was held in Southampton February 10 and 11, 2017 with the aim of presenting validating clinical practice guidelines for laparoscopic liver surgery.
Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has been tested in various indications clinical scenarios, leading to steady improvements safety. This report presents the current status of ALPPS.ALPPS offers improved resectability, but drawbacks are regularly pointed out regarding safety oncologic benefits.During 12th biennial congress European African-Hepato-Pancreato-Biliary Association (Mainz, Germany, May 23-26, 2017) an expert meeting "10th...
Objectives: To analyze long-term oncological outcome along with prognostic risk factors in a large cohort of patients colorectal liver metastases (CRLM) undergoing ALPPS. Background: ALPPS is two-stage hepatectomy variant that increases resection rates and R0 primarily unresectable CRLM as evidenced recent randomized controlled trial. Long-term oncologic results, however, are lacking. Methods: Cases in- outside the International Registry were collected completed by direct contacts to centers...
See also: Commentaire de travail P. R. Reuver et al., pp. 637Endoscopy 2008; 40(08): 796-797DOI: 10.1055/s-0032-1306858
Background: Photodynamic therapy (PDT) has been successfully used to treat various solid tumors. However, some cancer types respond poorly PDT, including urothelial carcinomas, nasopharyngeal and extrahepatic cholangiocarcinomas. The therapeutic recalcitrance is in part due the use of photosensitizers with suboptimal optical/ photochemical properties unfavorable pharmacokinetics. Objective: To circumvent these drawbacks, a secondgeneration photosensitizer improved optical/photochemical...
Preoperative biliary drainage is often initiated with endoscopic retrograde cholangiopancreatography (ERCP) in patients potentially resectable perihilar cholangiocarcinoma (PHC), but additional percutaneous transhepatic catheter (PTC) frequently required. This study aimed to develop and validate a prediction model identify high risk of inadequate ERCP drainage.Patients PHC (attempted) preoperative were included from two specialty center cohorts between 2001 2013. Indications for PTC failure...
Recently it was discovered that tissue-resident macrophages derive from embryonic precursors, not only peripheral blood monocytes, and maintain themselves by self-renewal. Most in-vitro studies on macrophage biology make use of cultured human monocyte-derived macrophages. Phagocytosis IgG-opsonized particles takes place via interaction with IgG receptors, the Fc-gamma receptors (FcγRs). We investigated FcγR expression both in-vivo ex-vivo different tissues. Upon isolation primary bone...
Purpose: This research presents an experimental study using validated questionnaires to quantitatively assess the outcomes of art-based observational training in medical students, residents, and specialists. The tested hypothesis that would lead measurable effects on judgement skills (tolerance ambiguity) empathy students doctors.Methods: An cohort with pre- post-intervention assessments was conducted qualitative evaluation forms examine doctors. Between December 2023 June 2024, 15 art...
Objective: Donor liver preservation methods and solutions have evolved over the last years. Liver sinusoidal endothelial cell (LSEC) barrier function integrity during is crucial for outcomes of transplantation. Therefore, present study aimed to determine optimal LSEC integrity, using different solutions. Methods: Human Umbilical Vein Endothelial Cells (HUVEC) were incubated in either University Wisconsin machine perfusion solution (UW-MPS), histidine-tryptophan-ketoglutarate (HTK), or growth...
Abstract Background Bile duct injury (BDI) remains a daunting complication of laparoscopic cholecystectomy. In patients with complex BDI, percutaneous-endoscopic rendezvous procedure may be required to establish bile continuity. The aim this study was assess short- and long-term outcomes the procedure. Methods All consecutive BDI referred our tertiary referral center between 1995 2016 were analyzed. A performed when endoscopic or radiologic intervention failed, deemed feasible by dedicated...
Abstract Background Consensus on resectability criteria for colorectal cancer liver metastases (CRLM) is lacking, resulting in differences therapeutic strategies. This study evaluated variability of assessments and local treatment plans patients with initially unresectable CRLM by the expert panel from randomised phase III CAIRO5 study. Methods The panel, comprising surgeons radiologists, predefined at baseline 2-monthly thereafter. If judged as resectable, detailed were provided. chair...
Abstract Background & Aims Hepatocellular secretory failure induced by drugs, toxins or transient biliary obstruction may sometimes persist for months after removal of the initiating factor and then be fatal without liver transplantation. We characterized patients with severe persistent hepatocellular ( PHSF ) treated them pregnane X receptor PXR agonist, rifampicin. also studied effect rifampicin on ‐dependent expression genes involved in biotransformation secretion vitro . Methods...
Gallbladder cancer (GBC) is rare in Western populations and data about treatment outcomes are scarce. This study aims to analyze survival identify opportunities for improvement using population-based from a low-incidence country. GBC patients diagnosed between 2005 2016 with were identified the Netherlands Cancer Registry. Patients grouped according time period (2005-2009/2010-2016) disease stage. Trends overall (OS) analyzed. In total 1834 included: 661 (36%) resected, 278 (15%)...
Although photodynamic therapy (PDT) yields very good outcomes in numerous types of superficial solid cancers, some tumors respond suboptimally to PDT. Novel treatment strategies are therefore needed enhance the efficacy these therapy-resistant tumors. One is combine PDT with inhibitors PDT-induced survival pathways. In this respect, transcription factor nuclear κB (NF-κB) has been identified as a potential pharmacological target, albeit inhibition NF-κB may concurrently dampen subsequent...