Joanne Verheij
A5045590497- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Immunotherapy and Immune Responses
- Pancreatitis Pathology and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Eosinophilic Esophagitis
- Congenital gastrointestinal and neural anomalies
- IgG4-Related and Inflammatory Diseases
- Drug Transport and Resistance Mechanisms
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Genetic and Kidney Cyst Diseases
- Eosinophilic Disorders and Syndromes
- Diet, Metabolism, and Disease
University of Amsterdam
2016-2025
Amsterdam University Medical Centers
2016-2025
Cancer Center Amsterdam
2018-2025
Dutch Cancer Society
2025
University Medical Center Groningen
2015-2024
University of Groningen
2015-2024
Amsterdam UMC Location University of Amsterdam
2012-2022
Emma Kinderziekenhuis
2021
Metropolitan University
2016-2021
John Wiley & Sons (United Kingdom)
2020
<h3>Importance</h3> The recently released eighth edition of the American Joint Committee on Cancer TNM staging system for pancreatic cancer seeks to improve prognostic accuracy but lacks international validation. <h3>Objective</h3> To validate in an cohort patients with resected ductal adenocarcinoma. <h3>Design, Setting, and Participants</h3> This multicenter study took place 5 tertiary centers Europe United States from 2000 2015. Patients who underwent pancreatoduodenectomy nonmetastatic...
<h3>Objective</h3> The value of surveillance for patients with Barrett9s oesophagus (BO) is under discussion given the overall low incidence neoplastic progression and lack discriminative tests risk stratification. Histological diagnosis low-grade dysplasia (LGD) only accepted predictor to date, but has a predictive value. aim this study was therefore evaluate p53 immunohistochemistry predicting in BO. <h3>Design</h3> We conducted case–control within prospective cohort 720 Patients who...
PurposeUsing exome sequencing, the underlying variants in many persons with autosomal recessive diseases remain undetected. We explored Stargardt disease (STGD1) as a model to identify missing heritability.MethodsSequencing of ABCA4 was performed 8 STGD1 cases one variant and p.Asn1868Ile trans, 25 variant, 3 no variant. The effect intronic analyzed using vitro splice assays HEK293T cells patient-derived fibroblasts. Antisense oligonucleotides were used correct defects.ResultsIn 24 probands...
The oncological safety of minimally invasive surgery has been questioned for several abdominal cancers. Concerns also exist regarding the use distal pancreatectomy (MIDP) in patients with resectable pancreatic cancer as randomised trials are lacking.In this international non-inferiority trial, we recruited adults from 35 centres 12 countries. Patients were randomly assigned to either MIDP (laparoscopic or robotic) open (ODP). Both and pathologists blinded approach. Primary endpoint was...
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty disease, encompasses steatosis and metabolic steatohepatitis (MASH), leading to cirrhosis hepatocellular carcinoma. Preclinical MASLD research is mainly performed in rodents; however, the model that best recapitulates human yet be defined. We conducted a wide-ranging retrospective review (metabolic phenotype, histopathology, transcriptome benchmarked against humans) of murine...
To investigate the correlation between magnetic resonance (MR) imaging findings and pathologic subtype classification of hepatocellular adenoma (HCA).This retrospective study was approved by institutional review board, requirement for informed consent waived. MR studies 61 lesions (48 patients; median age, 36 years) were available independently reviewed two radiologists. Consensus readings on all morphologic signal-intensity features obtained. Previously, these had been classified basis...
A randomized, double-blind, placebo-controlled study was conducted to investigate the safety and efficacy of mipomersen, an apolipoprotein B-100 (apoB) synthesis inhibitor, in patients who are statin intolerant at high risk for cardiovascular disease (CVD).Thirty-three subjects, not receiving therapy because intolerance, received a weekly subcutaneous dose 200 mg mipomersen or placebo (2:1 randomization) 26 weeks. The primary endpoint per cent change LDL cholesterol (LDL-c) from baseline...
Abstract Background Recent literature has shown increasing incidence and prevalence rates of eosinophilic esophagitis (EoE). However, data are mainly based on small studies come from centers dedicated to EoE. Aim this study was estimate the EoE by using a large database. Methods We performed cross‐sectional pathology reports describing esophageal eosinophilia 1996 through 2010, nationwide network registry histo‐ cytopathology in The Netherlands (PALGA). All histopathology enter classified...
Abstract The mechanisms that enable liver cancer to escape elimination by the immune system remain unclear, but their elucidation may provide novel therapeutic interventions. We investigated influence of tumor-infiltrating regulatory T cells on tumor-specific cell responses in patients with cancer, using ex vivo isolated from individuals hepatocellular carcinoma (HCC) or metastases colorectal (LM-CRC). Here we report both HCC and LM-CRC, CD4+CD25+Foxp3+ (Tregs) accumulate tumor milieu are...
Objective: To compare crystalloid and colloid fluids in their effect on pulmonary edema hypovolemic septic nonseptic patients with or at risk for acute lung injury/acute respiratory distress syndrome. We hypothesized that 1) loading results more formation than 2) the differences among types of fluid decreases high permeability. Design, Setting, Patients: Prospective randomized clinical trial 24 mechanically ventilated hypovolemia. Interventions: Patients were assigned to NaCl 0.9%, gelatin...
Abstract Immunoglobulin G4 (IgG4)-associated cholangitis (IAC) is a manifestation of the recently discovered idiopathic IgG4-related disease. The majority patients have elevated serum IgG4 levels and/or IgG4-positive B-cell and plasma cell infiltrates in affected tissue. We hypothesized that clonally expanded, class-switched B cells could be causal to these poorly understood phenomena. In prospective cohort six consecutive IAC patients, healthy controls, disease we used novel next-generation...
BackgroundIn recent years, new treatment options have become available for pancreatic ductal adenocarcinoma (PDAC) including 5-fluorouracil, leucovorin, irinotecan and oxaliplatin. The impact hereof has not been assessed in nationwide cohort studies. This population-based study aimed to investigate trends incidence, survival of PDAC.Materials methodsPatients with PDAC (1997–2016) were included from the Netherlands Cancer Registry. Results categorised by period diagnosis (1997–2000,...
Inherited eye disorders have a large clinical and genetic heterogeneity, which makes diagnosis cumbersome. An exome-sequencing approach was developed in data analysis divided into two steps: the vision gene panel exome analysis. In analysis, variants genes known to cause inherited were assessed for pathogenicity. If no causative detected when patient consented, entire analyzed. A total of 266 Dutch patients with different types disorders, including retinal dystrophies, cataract,...
Novel systemic treatments for hepatocellular carcinoma (HCC) are strongly needed. Immunotherapy is a promising strategy that can induce specific antitumor immune responses. Understanding the mechanisms of resistance by HCC crucial development suitable immunotherapeutics. We used immunohistochemistry on tissue-microarrays to examine co-expression inhibiting molecules PD-L1, Galectin-9, HVEM and IDO, as well tumor CD8+ lymphocyte infiltration in HCC, two independent cohorts patients. found at...