A5041852736- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Pancreatic and Hepatic Oncology Research
- Diet and metabolism studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Gallbladder and Bile Duct Disorders
- Metabolism and Genetic Disorders
- Frailty in Older Adults
- Colorectal Cancer Treatments and Studies
- Pancreatitis Pathology and Treatment
- Liver physiology and pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Gut microbiota and health
- Muscle metabolism and nutrition
- Radiomics and Machine Learning in Medical Imaging
- Enhanced Recovery After Surgery
- Intensive Care Unit Cognitive Disorders
- Cancer, Hypoxia, and Metabolism
- Mass Spectrometry Techniques and Applications
Maastricht University
2016-2025
Maastricht University Medical Centre
2015-2024
RWTH Aachen University
2017-2024
Universitätsklinikum Aachen
2017-2024
Essen University Hospital
2006-2024
University Medical Center
2008-2024
University College London
2011-2022
The Royal Free Hospital
2010-2022
Center for Translational Molecular Medicine
2021
Edinburgh Royal Infirmary
1999-2020
Background & aimsIntestinal failure (IF) is not included in the list of PubMed Mesh terms, as term describing a state non functioning other organs, and such well recognized. No scientific society has yet devised formal definition classification IF. The European Society for Clinical Nutrition Metabolism guideline committee endorsed its "home artificial nutrition chronic IF" "acute special interest groups to write recommendations on these issues.MethodsAfter Medline Search, December 2013,...
Abstract Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated effects colonic administration physiologically relevant SCFA mixtures on human substrate energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25–35 kg/m 2 ) underwent four investigational days, during which (200 mmol/L) high either acetate (HA), propionate (HP), butyrate (HB) or...
Abstract Background Cancer cachexia and skeletal muscle wasting are related to poor survival. In this study, quantitative body composition measurements using computed tomography (CT) were investigated in relation survival, post‐operative complications, surgical site infections patients with cancer of the head pancreas. Methods A prospective cohort 199 pancreas was analysed by CT imaging at L3 level determine (i) radiation attenuation (average Hounsfield units total muscle); (ii) visceral...
Gut microbial-derived short-chain fatty acids (SCFA) are believed to affect host metabolism and cardiometabolic risk factors. The present study aim was investigate the effects of proximal distal colonic infusions with SCFA acetate on fat oxidation other metabolic parameters in men. In this randomized, double-blind crossover trial, six overweight/obese men [body mass index (BMI) 25-35 kg/m2] underwent two experimental periods: one sodium infusions. A feeding catheter endoscopically positioned...
Objective Environmental factors driving the development of type 1 diabetes (T1D) are still largely unknown. Both animal and human studies have shown an association between altered fecal microbiota composition, impaired production short-chain fatty acids (SCFA) T1D onset. However, observational evidence on SCFA oral in adults with longstanding vs healthy controls (HC) is lacking. Research design methods We included 53 patients without complications or medication 50 HC matched for age, sex...
Abstract Background Malnutrition, weight loss, and muscle wasting (sarcopenia) are common among women with advanced ovarian cancer have been associated adverse clinical outcomes survival. Our objective is to investigate overall survival (OS) related changes in skeletal (SM) for patients treated neoadjuvant chemotherapy interval debulking. Methods Ovarian ( n = 123) debulking the area of Maastricht (the Netherlands) between 2000 2014 were included retrospectively. Surface areas SM adipose...
Abstract Following birth, the neonatal intestine is exposed to maternal and environmental bacteria that successively form a dense highly dynamic intestinal microbiota. Whereas effect of exogenous factors has been extensively investigated, endogenous, host-mediated mechanisms have remained largely unexplored. Concomitantly with microbial colonization, liver undergoes functional transition from hematopoietic organ central metabolic regulation immune surveillance. The aim present study was...
Ammonia is central to the pathogenesis of hepatic encephalopathy. This study was designed determine quantitative dynamics ammonia metabolism in patients with cirrhosis and previous treatment a transjugular intrahepatic portosystemic stent shunt (TIPSS). We studied 24 who underwent TIPSS portography. Blood sampled blood flows were measured across portal drained viscera, leg, kidney, liver, arteriovenous differences spleen inferior superior mesenteric veins. The highest amount produced by...
Abstract Background Computed tomography measurements of total skeletal muscle area can detect changes and predict overall survival (OS) in patients with advanced ovarian cancer. This study investigates whether assessment psoas reflects be used to assess sarcopenia cancer patients. Methods Ovarian ( n = 150) treated induction chemotherapy interval debulking were enrolled retrospectively this longitudinal study. Muscle was measured cross sectionally computed three ways: (i) software...
Abstract Background Enterocutaneous fistulas (ECF) pose a major challenge to every gastrointestinal (GI) surgeon. Based on earlier studies, standardized treatment guideline was implemented. The focus of the present study assess that and determine prognostic factors for outcome patients with ECF, define more detailed therapeutic approach including convalescence time before restorative surgery. Methods All ECF treated between 1990 2005 were included. Management consisted controlling Sepsis,...