A5045842912- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Muscle metabolism and nutrition
- Gut microbiota and health
- Nutritional Studies and Diet
- Cardiovascular and exercise physiology
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- Dietary Effects on Health
- Hormonal Regulation and Hypertension
- High Altitude and Hypoxia
- Regulation of Appetite and Obesity
- Nutrition and Health in Aging
- Obesity and Health Practices
- Diet, Metabolism, and Disease
- COVID-19 Clinical Research Studies
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Thermoregulation and physiological responses
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
Maastricht University Medical Centre
2016-2025
Maastricht University
2016-2025
University Medical Center
2012-2024
Diabetes Australia
2020-2024
TiFN
2017-2023
European Association for the Study of Obesity
2019-2021
Novartis (Switzerland)
2017
Medizinische Hochschule Hannover
2017
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2017
University of Cologne
2017
Short (<10 days) periods of muscle disuse, often necessary for recovery from illness or injury, lead to various negative health consequences. The current study investigated mechanisms underlying disuse-induced insulin resistance, taking into account atrophy. Ten healthy, young males (age: 23 ± 1 years; BMI: 23.0 0.9 kg · m(-2)) were subjected week strict bed rest. Prior and after rest, lean body mass (dual-energy X-ray absorptiometry) quadriceps cross-sectional area (CSA; computed...
Background— Adipose tissue (AT) dysfunction in obesity contributes to chronic, low-grade inflammation that predisposes type 2 diabetes mellitus and cardiovascular disease. Recent vitro studies suggest AT hypoxia may induce inflammation. We hypothesized adipose blood flow (ATBF) regulates oxygen partial pressure (AT P o ), thereby affecting insulin sensitivity. Methods Results— developed an optochemical measurement system for continuous monitoring of using microdialysis. The effect...
Abstract Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated effects colonic administration physiologically relevant SCFA mixtures on human substrate energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25–35 kg/m 2 ) underwent four investigational days, during which (200 mmol/L) high either acetate (HA), propionate (HP), butyrate (HB) or...
Abstract Microbial-derived short-chain fatty acids (SCFA) acetate, propionate and butyrate may provide a link between gut microbiota whole-body insulin sensitivity (IS). In this cross-sectional study (160 participants, 64% male, BMI: 19.2–41.0 kg/m 2 , normal or impaired glucose metabolism), associations SCFA (faecal fasting circulating) circulating metabolites, substrate oxidation IS were investigated. subgroup (n = 93), was determined using hyperinsulinemic-euglycemic clamp. Data analyzed...
Abstract Obesity is associated with a disturbed adipose tissue (AT) function characterized by adipocyte hypertrophy, an impaired lipolysis and pro-inflammatory phenotype, which contributes to insulin resistance (IR). We investigated whether AT phenotype in different depots of obese individuals without type 2 diabetes mellitus (T2DM) whole-body IR. Subcutaneous (SC) visceral (V) biopsies from 18 lean, 17 8 T2DM men were collected. was ex vivo measurement basal stimulated (mature adipocytes),...
Obesity is a frequent, serious, complex, relapsing, and chronic disease process that represents major public health problem. The coining of obesity as an adiposity-based (ABCD) particular relevance being in line with EASO’s proposal to improve the International Classification Diseases ICD-11 diagnostic criteria for based on three dimensions, namely etiology, degree adiposity, risks. body mass index unique measurement does not reflect whole complexity disease. complications are mainly...
Pancreatic fat content (PFC) may have deleterious effects on β-cell function.We hypothesized that ectopic deposition, in particular pancreatic accumulation, is related to dysfunction individuals with impaired fasting glucose (IFG) and/or tolerance (IGT).This was a cross-sectional study 64 age- and body mass index-matched individuals, normal (NGT; n = 16, 60% males), IFG (n 29, 52% or IFG/IGT 19, 63% males) conducted.Participants underwent the following: 1) combined...
Objective— Dysregulation of inflammatory adipokines by the adipose tissue plays an important role in obesity-associated insulin resistance. Pathways leading to this dysregulation remain largely unknown. We hypothesized that receptor for advanced glycation end products (RAGE) and ligand N ε -(carboxymethyl)lysine (CML) are increased and, moreover, activation CML–RAGE axis inflammation Approach Results— In study, we observed a strong CML accumulation expression RAGE obesity. confirmed cultured...
Natriuretic peptide (NP) deficiency and sustained renin‐angiotensin system activation are associated with impaired oxidative metabolism predispose to type‐2 diabetes. We hypothesized that sacubitril/valsartan (LCZ696), which augments NP through neprilysin inhibition while blocking angiotensin II type‐1 (AT 1 )‐receptors, improves insulin sensitivity, lipid mobilization, oxidation. After 8 weeks of treatment obese patients hypertension, 400 mg q.d., but not amlodipine 10 was a significant...