A5100635616- Diet and metabolism studies
- Cellular Automata and Applications
- Computability, Logic, AI Algorithms
- Gut microbiota and health
- Mathematical and Theoretical Epidemiology and Ecology Models
- Nutritional Studies and Diet
- advanced mathematical theories
- Adipose Tissue and Metabolism
- DNA and Biological Computing
- Engineering and Information Technology
- Muscle metabolism and nutrition
- Differential Equations and Numerical Methods
- Aquatic and Environmental Studies
- Advanced Computational Techniques and Applications
- Genomics and Rare Diseases
- Mathematical Biology Tumor Growth
- Genetic factors in colorectal cancer
- Mathematical Dynamics and Fractals
- Material Science and Thermodynamics
- Knowledge Societies in the 21st Century
- Machine Fault Diagnosis Techniques
- Diet, Metabolism, and Disease
- Speech and Audio Processing
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Educational Innovations and Technology
Centre for Human Drug Research
2024
Maastricht University
2018-2021
Universidad Autónoma del Estado de Hidalgo
2007-2021
Maastricht University Medical Centre
2018-2020
Abstract Microbial-derived short-chain fatty acids (SCFA) acetate, propionate and butyrate may provide a link between gut microbiota whole-body insulin sensitivity (IS). In this cross-sectional study (160 participants, 64% male, BMI: 19.2–41.0 kg/m 2 , normal or impaired glucose metabolism), associations SCFA (faecal fasting circulating) circulating metabolites, substrate oxidation IS were investigated. subgroup (n = 93), was determined using hyperinsulinemic-euglycemic clamp. Data analyzed...
Gut-derived short-chain fatty acids (SCFA), formed by microbial fermentation of dietary fibers, are believed to be involved in the etiology obesity and diabetes. Previous data from our group showed that colonic infusions physiologically relevant SCFA mixtures attenuated whole-body lipolysis overweight men. To further study potential mechanisms antilipolytic properties SCFA, we aimed investigate vitro effects incubations on intracellular signaling using a human white adipocyte model,...
Genome-wide association studies (GWAS) have become a common method for discovery of gene-disease relationships, in particular complex diseases like Type 2 Diabetes Mellitus (T2DM). The experience with GWAS analysis has revealed that the genetic risk involves cumulative, small effects many genes and only some moderate effect. In order to explore complexity relationships between T2DM their potential function at process level as effected by polymorphism effects, secondary meta-analysis is...
The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide. Drug therapy hampered by large patient variability partial representation human MASH in preclinical models. Here, we investigated the mechanisms underlying heterogeneity using a discovery dataset validated distinct transcriptomic datasets, to improve stratification translation into subgroup specific patterns. Patient was performed weighted gene co-expression network analysis (WGCNA) public (n = 216)....
Microbially-produced acetate has been reported to beneficially affect metabolic health through effects on satiety, energy expenditure, insulin sensitivity, and substrate utilization. Here, we investigate the association between sex-specific concentrations of sensitivity/resistance indices (Homeostatic Model Assessment Insulin Resistance (HOMA-IR), circulating Matsuda Index) in Diet, Obesity Genes (DiOGenes) Dietary study at baseline after a low-calorie diet (LCD, 800 kcal/d). In this...
This paper exposes a procedure for modeling and solving linear systems using continuous-valued cellular automata. The original part of this work consists on showing how the cells in automaton may contain both real values operators carrying out numerical calculations solve desired problem. In sense acts as program, where data are mixed evolution space obtaining correct calculations. As an example, Euler's integration method is implemented configuration order to achieve approximated solution...
The gut microbiota may affect host metabolic health through microbial metabolites. balance between the production of metabolites by saccharolytic and proteolytic fermentation be an important determinant health. Amongst best-studied are short-chain fatty acids acetate, propionate butyrate. However, human data on role other by-products in greatly lacking. Therefore, we compared a cross-sectional study faecal (caproate, lactate, valerate, succinate, branched-chain (BCFA) (isobutyrate,...
In this paper, we consider systems with one resource, which can be in several states. The states differ significantly their processes of mortality, reproduction and mutual influence. For instance, infected elements have a higher mortality rate than healthy recovered ones. cyclic models, the initial state system coincides final state, balance relations are found. They represent functional operators shift integrals degenerate kernels. Modified Fredholm method, proposed previous works to solve...
The purpose of this paper is to show an alternative teach how people can do mathematical modeling natural sciences such as physics, biology, earth science, meteorology and engineering disciplines like computer artificial intelligence, but also social economics, psychology, sociology political science using semantic networks in order get a graphical view the relationships between components problem be modeled.The main idea use perform connection involved with concepts, operators all possible...
Our recent in vivo human studies showed that colonic administration of sodium acetate (SA) resulted increased circulating levels, which was accompanied by increments whole-body fat oxidation overweight-obese men. Since skeletal muscle has a major role oxidation, we aimed to investigate effects SA on and underlying mechanisms primary cells (HSkMC). We investigated the dose (0-5 mmol/L) time (1, 4, 20, 24 h) effect complete incomplete endogenous exogenous 14C-labeled palmitate HSkMC derived...
Tradicionalmente, la enseñanza de las matemáticas ha sido un desafío para todos los que, una u otra forma, quieren enseñar cómo resolver problemas, particularmente cuando se tiene que generar modelo represente en forma abstracta solución del problema. El propósito este artículo, es mostrar alternativa modelación matemática utilizando redes semánticas obtener visualización gráfica relaciones entre componentes problema quiere modelar, facilitando al lector comprensión formar el matemático.
Reversible cellular automata are discrete invertible dynamical systems determined by local interactions among their components. For the one-dimensional case, there classical references providing a complete characterization based on combinatorial properties. Using these results and simulation of every automaton another with neighborhood size 2, this paper describes other types behaviors embedded in different from one observed temporal evolution. In particular, spatial reversibility diagonal...