A5068612501- Genetics and Neurodevelopmental Disorders
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Biomedical Text Mining and Ontologies
- Genomics and Phylogenetic Studies
- Generative Adversarial Networks and Image Synthesis
- Lipid metabolism and disorders
- Genomics and Rare Diseases
- AI in cancer detection
- Nanomaterials for catalytic reactions
- Epigenetics and DNA Methylation
- Machine Learning in Healthcare
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Wireless Body Area Networks
- Plant Molecular Biology Research
- Computational Drug Discovery Methods
- Animal Genetics and Reproduction
- Gene Regulatory Network Analysis
- Molecular Communication and Nanonetworks
- Chromosomal and Genetic Variations
- Energy Efficient Wireless Sensor Networks
- Plant nutrient uptake and metabolism
The Hyve (Netherlands)
2020-2023
Radboud University Nijmegen
2020
Maastricht University
2015-2019
Maastricht University Medical Centre
2019
Pension Fund for Care and Well-Being
2017
University of Bologna
2013
WikiPathways (wikipathways.org) captures the collective knowledge represented in biological pathways. By providing a database curated, machine readable way, omics data analysis and visualization is enabled. other pathway databases are used to analyze experimental by research groups many fields. Due open collaborative nature of platform, our content keeps growing getting more accurate, making reliable rich database. Previously, however, focus was primarily on genes proteins, leaving...
WikiPathways (http://www.wikipathways.org) is an open, collaborative platform for capturing and disseminating models of biological pathways data visualization analysis. Since our last NAR update, 4 years ago, has experienced massive growth in content, which continues to be contributed by hundreds individuals each year. New aspects the diversity depth collected are described from perspective researchers interested using pathway information their studies. We provide updates on extensions...
Significance We show that the characteristic variation in density of grains observed along inflorescence (spike) modern cultivated barley ( Hordeum vulgare ) is consequence a perturbed interaction between microRNA, miR172, and its corresponding binding site mRNA an APELATA2 AP2 )-like transcription factor, HvAP2 . Our data indicate miR172-driven turnover regulates length developmental window required for elongation internodes axis spike, this results striking differences size shape inflorescence.
Genome-wide association studies (GWAS) have become a common method for discovery of gene-disease relationships, in particular complex diseases like Type 2 Diabetes Mellitus (T2DM). The experience with GWAS analysis has revealed that the genetic risk involves cumulative, small effects many genes and only some moderate effect. In order to explore complexity relationships between T2DM their potential function at process level as effected by polymorphism effects, secondary meta-analysis is...
Objectives Rett syndrome (RTT) is a rare disorder causing severe intellectual and physical disability. The cause mutation in the gene coding for methyl-CpG binding protein 2 (MECP2), multifunctional regulator protein. Purpose of study was integration investigation multiple expression profiles human cells with impaired MECP2 to obtain robust, data-driven insight molecular disease mechanisms.Methods Information about changed extracted from five previously published studies, integrated...
The analysis of transcriptomics data is able to give an overview cellular processes, but requires sophisticated bioinformatics tools and methods identify the changes. Pathway software, like PathVisio, captures information about biological pathways from databases brings this together with experimental enable visualization understanding underlying processes. Rett syndrome a rare disease, still one most abundant causes intellectual disability in females. Cause neurological disorder mutation...
After being collected for patient care, Observational Health Data (OHD) can further benefit well-being by sustaining the development of health informatics and medical research. Vast potential is unexploited because fiercely private nature patient-related data regulation about its distribution. Generative Adversarial Networks (GANs) have recently emerged as a groundbreaking approach to learn generative models efficiently that produce realistic Synthetic (SD). They revolutionized practices in...
Abstract Rett syndrome (RTT) is a rare disorder causing severe intellectual and physical disability. The cause mutation in the gene coding for methyl-CpG binding protein 2 (MECP2), multifunctional regulator protein. Purpose of study was integration investigation multiple expression profiles human cells with impaired MECP2 to obtain data-driven insight downstream effects. Information about changed extracted from five previously published studies. We identified set genes which are...
Angiopoietin like protein 8 (ANGPTL8) is a newly identified hormone with unique nature due to its ability regulate both glucose and lipid metabolic pathways. It characterized as an important molecular player of insulin induced nutrient storage utilization pathway during fasting re-feeding transition. Several studies have contributed increase our knowledge regarding function mechanism action. Moreover, altered expression levels been observed in Insulin Resistance, Diabetes Mellitus (Types I...
The Swiss Personalized Health Network (SPHN) is a research infrastructure initiative that aims to facilitate the exchange of health-related data in FAIR manner. SPHN Dataset and RDF Schema form an essential part Semantic Interoperability Framework, which currently covers mostly clinical routine data. To integration omics produced by National Data Streams, genomics extension was developed. This done close collaboration with clinicians, researchers, bioinformaticians, managers, from university...
The behavioral analysis of animals is fundamental for the biomedical disciplines as it allows to study specific pathologies reproduced in laboratory and/or evaluate efficacy new pharmacological therapies before experimenting them on human beings. Nevertheless, gathering data related animal behavior not immediate: lab are similar each other, making impossible use procedures based computer vision well operators. On contrary, systems Radio Frequency Identification (RFID) technology Ultra High...
After being collected for patient care, Observational Health Data (OHD) can further benefit well-being by sustaining the development of health informatics and medical research. Vast potential is unexploited because fiercely private nature patient-related data regulation about its distribution. Generative Adversarial Networks (GANs) have recently emerged as a groundbreaking approach to learn generative models efficiently that produce realistic Synthetic (SD). They revolutionized practices in...
Abstract Rett syndrome (RTT) is a rare disease but still one of the most abundant causes for intellectual disability in females. Typical symptoms are onset at month 6-18 after normal pre-and postnatal development, loss acquired skills and severe disability. The type severity individually highly different. A single mutation gene, coding methyl-CpG-binding protein 2 (MECP2), responsible disease. important action MECP2 regulating epigenetic imprinting chromatin condensation, influences many...
<ns7:p>Database identifier mapping services are important to make database information interoperable. BridgeDb offers such a service. Available for link 1. genes and gene products identifiers, 2. metabolite identifiers InChI structure description, 3. biochemical reactions interactions between multiple resources that use IDs while the mappings obtained from sources. In this study we created databases selections of genes-to-variants (and variants-to-genes) based on variants described in...