A5050967876- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Regulation of Appetite and Obesity
- Nuclear Receptors and Signaling
- Fatty Acid Research and Health
- Lipid metabolism and disorders
- Macrophage Migration Inhibitory Factor
- Apelin-related biomedical research
- Phytochemicals and Antioxidant Activities
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- Liver Diseases and Immunity
- Lipoproteins and Cardiovascular Health
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Neuroinflammation and Neurodegeneration Mechanisms
Netherlands Organisation for Applied Scientific Research
2015-2024
Netherlands Metabolomics Centre
2015-2023
Wageningen University & Research
2018-2022
Queen Mary University of London
2022
TiFN
2016
Salve Regina University
2016
University Medical Center Groningen
2014-2015
University of Groningen
2014-2015
Food & Nutrition
2014
Morrison Tech
2014
Development of non-alcoholic fatty liver disease (NAFLD) is linked to obesity, adipose tissue inflammation, and gut dysfunction, all which depend on diet. So far, studies have mainly focused diet-related fecal microbiota changes, but other compartments may be more informative host health. We present a first systematic analysis changes in the ileum colon using multiple diets investigating both mucosal samples. Ldlr−/−.Leiden mice received one three different energy-dense (ED)-diets (n =...
Aging | doi:10.18632/aging.100738. Roel A van der Heijden, Fareeba Sheedfar, Martine C Morrison, Pascal PH Hommelberg, Danny Kor, Niels J Kloosterhuis, Nanda Gruben, Sameh Youssef, Alain de Bruin, Marten H Hofker, Robert Kleemann, Debby PY Koonen, Peter Heeringa
Besides LDL-cholesterol, local vascular inflammation plays a key role in atherogenesis. Efficient therapies to treat the inflammatory component of disease have not been established. The discovery specialized inflammation-resolving mediators, such as resolvins may provide new opportunities for treatment. This study examines whether ω-3 fatty acid eicosapentaenoic acid-derived resolvin E1 (RvE1), can reduce atherosclerosis, when administered alone or combination with cholesterol-lowering...
We previously identified subsets of patients with NAFLD different metabolic phenotypes. Here we align metabolomic signatures cardiovascular disease (CVD) and genetic risk factors.
Non-alcoholic fatty liver disease (NAFLD) is strongly associated with abdominal obesity. Growing evidence suggests that inflammation in specific depots of white adipose tissue (WAT) has a key role NAFLD progression, but experimental for causal WAT lacking. A time-course study C57BL/6J mice was performed to establish which depot most susceptible develop during high-fat diet (HFD)-induced Crown-like structures (CLS) were quantified epididymal (eWAT), mesenteric (mWAT) and inguinal/subcutaneous...
Semaglutide, a glucagon-like peptide-1 receptor agonist, is an antidiabetic medication that has recently been approved for the treatment of obesity as well. Semaglutide postulated to be promising candidate non-alcoholic steatohepatitis (NASH). Here, Ldlr-/-.Leiden mice received fast-food diet (FFD) 25 weeks, followed by another 12 weeks on FFD with daily subcutaneous injections semaglutide or vehicle (control). Plasma parameters were evaluated, livers and hearts examined, hepatic...
Anthocyanins may have beneficial effects on lipid metabolism and inflammation are demonstrated to hepatoprotective properties in models of restraint-stress- chemically-induced liver damage. However, their potential protect against non-alcoholic steatohepatitis (NASH) under conditions relevant for human pathogenesis remains unclear. Therefore, we studied the standardised anthocyanin-rich extract Mirtoselect diet-induced NASH a translational model disease.ApoE(∗)3Leiden mice were fed...
Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH) patients, bringing into question their translational value studies of therapeutic interventions the process NASH/fibrosis. We investigated representation patterns characteristic for human NASH high-fat diet (HFD)-fed Ldlr-/-.Leiden mice and studied effects obeticholic acid (OCA) on these profiles. Multiplatform serum metabolomic profiles...
Non-alcoholic steatohepatitis (NASH) is a serious liver condition, closely associated with obesity and insulin resistance. Recent studies have suggested an important role for inflammasome/caspase-1 in the development of NASH, but potential therapeutic value caspase-1 inhibition remains unclear. Therefore, we aimed to investigate effects ongoing disease process, mimic clinical setting. To under conditions, male LDLR−/−.Leiden mice were fed high-fat diet (HFD) 9 weeks induce pre-diabetic state...
The incidence of nonalcoholic steatohepatitis (NASH) is increasing. pathophysiological mechanisms NASH and the sequence events leading to hepatic fibrosis are incompletely understood. aim this study was gain insight into dynamics key molecular processes involved in rank early markers for fibrosis.A time-course low-density lipoprotein-receptor knockout. Leiden mice on a high-fat diet performed identify temporal contributing fibrosis. An integrative systems biology approach used elucidate...
Non-alcoholic steatohepatitis (NASH) is associated with a disturbed metabolism in liver, insulin resistance, and excessive accumulation of ectopic fat. Branched-chain amino acids (BCAAs) may beneficially modulate hepatic lipids, however, it remains unclear whether individual BCAAs can attenuate already established NASH oxidative-inflammatory stress. After 26 weeks run-in on fast food diet (FFD), obese Ldlr-/-.Leiden mice were treated for another 12 either valine or isoleucine (3% FFD) then...
Obesity is associated with impaired inhibitory control and low-grade systemic inflammation. Systemic inflammation adversely affects neurocognitive performance. Here, we investigate the effects of metabolic bariatric surgery on its influence neural mechanisms underlying control. In a sample 47 individuals obesity, assessed processing pre- 2 years post-bariatric by probing activation connectivity during an fMRI Stroop task. We investigated whether surgery-induced changes in plasma markers were...
Macrophage infiltration is a critical determinant of high-fat diet induced adipose tissue inflammation and insulin resistance. The precise mechanisms underpinning the initiation macrophage recruitment activation are unclear. migration inhibitory factor (MIF), pro-inflammatory cytokine, displays chemokine-like properties. Circulating MIF levels elevated during obesity however its role in resistance remains elusive. Wildtype MIF−/− C57Bl\6J mice were fed chow or diet. Body weight food intake...
Background and Aims As dietary saturated fatty acids are associated with metabolic cardiovascular disease, a potentially interesting strategy to reduce disease risk is modification of the quality fat consumed. Vegetable oils represent an attractive target for intervention, as they largely determine intake fats. Furthermore, besides potential health effects conferred by type in vegetable oil, other minor components (e.g. phytochemicals) may also have benefits. Here, we investigated long-term...
Introduction: It is generally accepted that metabolic inflammation in the liver an important driver of disease progression NASH and associated matrix remodeling/fibrosis. However, exact molecular inflammatory mechanisms are poorly defined human studies. Investigation key pathogenic requires use pre-clinical models, for instance time-resolved Such models must reflect processes importance patients. Herein we characterized patients on level by transcriptomics investigated whether pathways can...
The obesity epidemic increases the interest to elucidate impact of short-chain fatty acids on metabolism, obesity, and brain. We investigated effects propionic acid (PA) caproic (CA) metabolic risk factors, liver adipose tissue pathology, brain function, structure (by MRI), gene expression, during development in Ldlr−/−.Leiden mice. mice received 16 weeks either a high-fat diet (HFD) induce or chow as reference group. Next, obese HFD-fed were treated 12 with (a) HFD + CA (CA), (b) PA (PA),...
In obesity-associated non-alcoholic steatohepatitis (NASH), persistent hepatocellular damage and inflammation are key drivers of fibrosis, which is the main determinant NASH-associated mortality. The short-chain fatty acid butyrate can exert metabolic improvements anti-inflammatory activities in NASH. However, its effects on liver fibrosis remain unclear. Putative antifibrotic were studied Ldlr-/-.Leiden mice fed an obesogenic diet (HFD) containing 2.5% (w/w) for 38 weeks compared with a...
Patients with metabolic syndrome are often prescribed statins to prevent the development of cardiovascular disease. Conversely, data on their effects non-alcoholic steatohepatitis (NASH) lacking. We evaluated these by feeding APOE*3-Leiden mice a Western-type diet (WTD) or without atorvastatin induce NASH and hepatic fibrosis. Besides well-known plasma cholesterol lowering (-30%) anti-atherogenic (severe lesion size -48%), significantly reduced steatosis (-22%), number aggregated...
Background Obesity frequently associates with the development of non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. Chronic inflammation in white adipose tissue (WAT) seems to be an important driver these manifestations. Objective This study investigated a combination extensively hydrolyzed casein (eHC), docosahexaenoic acid (DHA), arachidonic (ARA), Lactobacillus Rhamnosus GG (LGG) (together referred as nutritional ingredients, NI) on obesity, metabolic risk factors, WAT...
Obesity is associated with chronic low-grade inflammation that drives the development of metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). We recently showed white adipose tissue (WAT) constitutes an important source inflammatory factors. Hence, interventions attenuate WAT may reduce NAFLD development. Male LDLr-/- mice were fed a high-fat diet (HFD) for 9 weeks followed by 7 HFD or without rosiglitazone. Effects on and analyzed using biochemical (immuno)histochemical...
Background Non-alcoholic fatty liver disease (NAFLD) is a complex multifactorial disorder that characterised by dysfunctional lipid metabolism and cholesterol homeostasis, related chronic inflammatory response. NAFLD has become the most common cause of in many countries, its prevalence continues to rise parallel with increasing rates obesity. Here, we evaluated putative NAFLD-attenuating effects multicomponent medicine consisting 24 natural ingredients: Hepar compositum (HC-24). Methods...