A5042771002- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diet and metabolism studies
- Hepatitis C virus research
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- Alcohol Consumption and Health Effects
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Peroxisome Proliferator-Activated Receptors
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Lipid metabolism and disorders
- Reproductive System and Pregnancy
- Colorectal Cancer Screening and Detection
- Adipose Tissue and Metabolism
- Reproductive Physiology in Livestock
- Folate and B Vitamins Research
- Radiomics and Machine Learning in Medical Imaging
OWL (Spain)
2012-2024
University of the Basque Country
2024
Euskadiko Parke Teknologikoa
2015-2023
Idom (Spain)
2020
American College of Gastroenterology
2019
Lymphatic Education & Research Network
2019
NIHR Clinical Research Network
2019
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited. Despite growing number studies linking with altered serum metabolite levels, an obstacle development metabolome-based NAFLD predictors has been lack large cohort data biopsy-proven patients matched for key metabolic features such as obesity. We studied 467 biopsied individuals normal histology (n = 90) or diagnosed (steatosis,...
Early and differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) hepatocellular carcinoma (HCC) by noninvasive methods represents a current clinical challenge. The analysis low‐molecular‐weight metabolites new high‐throughput techniques is strategy for identifying biomarkers. Here, we have investigated whether serum metabolome can provide useful biomarkers in the iCCA HCC could discriminate from HCC. Because primary sclerosing cholangitis (PSC) risk factor CCA, metabolic profiles...
Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic worldwide and includes a broad spectrum histologic phenotypes, ranging from simple hepatic steatosis or nonalcoholic (NAFL) to steatohepatitis (NASH). While biopsy reference gold standard for NAFLD diagnosis staging, it has limitations due its sampling variability, invasive nature, high cost. Thus, there need noninvasive biomarkers that are robust, reliable, cost effective. In this study, we measured 540 lipids amino...
Methionine adenosyltransferase 1A ( MAT1A ) and glycine N -methyltransferase GNMT are the primary genes involved in hepatic S-adenosylmethionine (SAMe) synthesis degradation, respectively. Mat1a ablation mice induces a decrease SAMe, activation of lipogenesis, inhibition triglyceride (TG) release, steatosis. Gnmt -deficient mice, despite showing large increase also develop We hypothesized that as an adaptive response to SAMe accumulation, phosphatidylcholine (PC) by way...
Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease (NAFLD) which sets stage for further damage. The mechanism progression NASH involves multiple parallel hits including oxidative stress, mitochondrial dysfunction, inflammation and others. Manipulation any these pathways may be an approach to prevent development progression. Aramchol (arachidyl-amido cholanoic acid) presently in a phase IIb study. aim this study was investigate Aramchol's action its...
OBJECTIVES: Specific microRNA (miRNA) signatures in biological fluids can facilitate earlier detection of the tumors being then minimally invasive diagnostic biomarkers. Circulating miRNAs have also emerged as promising biomarkers for colorectal cancer (CRC) screening. In this study, we investigated performance a specific signature miRNA plasma samples to design robust predictive model that distinguish healthy individuals from those with CRC or advanced adenomas (AA) diseases. METHODS: Case...
We previously identified subsets of patients with NAFLD different metabolic phenotypes. Here we align metabolomic signatures cardiovascular disease (CVD) and genetic risk factors.
Early identification of those with NAFLD activity score ≥ 4 and significant fibrosis (≥F2) or at-risk metabolic dysfunction-associated steatohepatitis (MASH) is a priority as these patients are at increased risk for disease progression may benefit from therapies. We developed validated highly specific metabolomics-driven to identify MASH.
Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH) patients, bringing into question their translational value studies of therapeutic interventions the process NASH/fibrosis. We investigated representation patterns characteristic for human NASH high-fat diet (HFD)-fed Ldlr-/-.Leiden mice and studied effects obeticholic acid (OCA) on these profiles. Multiplatform serum metabolomic profiles...
To assess the utility of existing metabolomics scores to classify liver disease in patients with type 2 diabetes mellitus (T2DM).A total 220 T2DM were recruited. Patients underwent routine laboratory tests, proton magnetic resonance spectroscopy (1 H-MRS), a 75-g oral glucose tolerance test, and biopsy if 1 H-MRS findings indicated non-alcoholic fatty disease. A serum sample was blindly provided OWL Metabolomics on which run OWLiver Care tests.When compared biopsy, tests had suboptimal...
The diagnosis of adenocarcinomas located in the pancreas head, i.e., distal cholangiocarcinoma (dCCA) and pancreatic ductal adenocarcinoma (PDAC), constitutes a clinical challenge because they share many symptoms, are not easily distinguishable using imaging techniques accurate biomarkers available. Searching for with potential usefulness differential these tumors, we have determined serum metabolomic profiles healthy controls patients dCCA, PDAC or benign diseases (BPD)....
Susceptibility to develop nonalcoholic fatty liver disease (NAFLD) has genetic bases, but the associated variants are uncertain. The aim of present study was identify that could help prognose and further understand genetics development NAFLD. Allele frequencies 3,072 single-nucleotide polymorphisms (SNPs) in 92 genes were characterized 69 NAFLD patients 217 healthy individuals. markers showed significant allele-frequency differences pilot groups subsequently studied 451 304 controls. Besides...
Abstract Liver fibrosis must be evaluated in patients with hepatitis C virus (HCV) after liver transplantation because its severity affects their prognosis and the recurrence of HCV. Since invasive biopsy is still gold standard to identify at risk graft loss from rapid progression, it becomes crucial development new accurate, non-invasive methods that allow repetitive examination patients. Therefore, we have developed a non-invasive, accurate model distinguish those different stages. Two...
In cirrhosis, a decrease in hepatic venous pressure gradient (HVPG) > 10% after acute iv propranolol (HVPG response) is associated with lower risk of decompensation and death. Only part patients are HVPG responders there no accurate non-invasive markers to identify them. We aimed at discovering metabolomic biomarkers propranolol.Sixty-six cirrhosis ≥ 10 mm Hg whom the response was assessed, were prospectively included. A targeted serum analysis using ultrahigh-performance liquid...
Low invasive tests with high sensitivity for colorectal cancer and advanced precancerous lesions will increase adherence rates, improve clinical outcomes. We have performed an ultra-performance liquid chromatography/time-of-flight mass spectrometry (UPLC-(TOF) MS)-based metabolomics study to identify faecal biomarkers the detection of patients neoplasia. A cohort 80 neoplasia (40 adenomas 40 cancers) 49 healthy subjects were analysed in study. evaluated levels 105 metabolites including...
Abstract Background and Aim Type 2 Diabetes mellitus (T2DM), age, obesity are risk factors for metabolic dysfunction‐associated steatotic liver disease (MASLD). We aimed to assess the performance of non‐invasive tests (NITs) diagnosis steatohepatitis (MASH) fibrosis in high‐risk subjects. Methods Multicentre cross‐sectional study that included 124 biopsy‐proven MASLD more than 50 years‐old patients with overweight/obesity T2DM. Vibration‐controlled transient elastography, Fibrosis‐4 index...
Alcoholic hepatitis is the most severe manifestation of alcoholic liver disease. Unfortunately, there are still some unresolved issues in diagnosis and management this disease, such as need histological diagnosis, an accurate prognostic stratification, development novel targeted therapies. The present study aimed at addressing these by means metabolomics, a high-throughput approach useful other diseases.
Despite its often low efficacy and high toxicity, the standard treatment for acute myeloid leukemia (AML) is induction chemotherapy with cytarabine idarubicin. Here, we have investigated role of transporters drug-metabolizing enzymes in this poor outcome. The expression levels (RT-qPCR) potentially responsible genes blasts collected at diagnosis were related to subsequent response two-cycle chemotherapy. uptake carriers (ENT2), export ATP-binding cassette (ABC) pumps (MDR1), (DCK, 5-NT, CDA)...
Metabolomics research has evolved considerably, particularly during the last decade. Over course of this evolution, interest in 'omic' discipline is now more evident than ever. However, future metabolomics will depend on its capability to find biomarkers. For that reason, data mining constitutes a challenging task workflow. This work been designed support article entitled "Enhancing through mining", which proposed methodological handling guideline. An aging healthy population was used as...