A5075319792- Folate and B Vitamins Research
- Pharmacological Effects and Toxicity Studies
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
- Epilepsy research and treatment
- Pregnancy and Medication Impact
- Congenital Anomalies and Fetal Surgery
- Metabolism and Genetic Disorders
- Prenatal Substance Exposure Effects
- Esophageal and GI Pathology
- Cleft Lip and Palate Research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Congenital heart defects research
- Hedgehog Signaling Pathway Studies
- Renal and related cancers
- Neurogenetic and Muscular Disorders Research
- Spinal Dysraphism and Malformations
- Genetics and Neurodevelopmental Disorders
- Craniofacial Disorders and Treatments
- Pluripotent Stem Cells Research
- Genomic variations and chromosomal abnormalities
- Fetal and Pediatric Neurological Disorders
- Connective tissue disorders research
- Genetic and Kidney Cyst Diseases
Baylor College of Medicine
2005-2025
The University of Texas at Austin
2013-2024
Rose Community Foundation
2024
Dell Children's Medical Center of Central Texas
2012-2024
Shanghai Children's Hospital
2024
Shanghai Jiao Tong University
2024
Children's Hospital of Wisconsin
2023
NeuroDevelopment Center
2021-2023
Baylor University
2023
Stanford University
2010-2022
We present here a method for broadly characterizing single cells at the molecular level beyond more common morphological and transmitter/receptor classifications. The RNA from defined is amplified by microinjecting primer, nucleotides, enzyme into acutely dissociated region of rat brain. Further processing yields antisense RNA. A second round amplification results in greater than 10(6)-fold original starting material, which adequate analysis--e.g., use as probe, making cDNA libraries, etc....
In 2007, the International Knockout Mouse Consortium (IKMC) made ambitious promise to generate mutations in virtually every protein-coding gene of mouse genome a concerted worldwide action. Now, 5 years later, IKMC members have developed high-throughput trapping and, particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones 1,700 strains, most them conditional. A common web portal (www.knockoutmouse.org) has been established, allowing...
Persistent organic pollutants (POPs) have been associated with a wide range of adverse health effects. Our case–control study was performed to explore the association between placental levels selected POPs and risks for neural tube defects (NTDs) in Chinese population high prevalence NTDs. Cases included 80 fetuses or newborns NTDs, whereas controls were 50 healthy, nonmalformed newborn infants. Placental concentrations polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides,...
Pregnancy outcomes following in utero exposure to antiepileptic drugs (AEDs) are uncertain, limiting an evidenced-based approach.To determine if fetal vary as a function of different AED exposures.This ongoing prospective observational study across 25 epilepsy centers the USA and UK enrolled pregnant women with from October 1999 February 2004 differential long-term cognitive behavioral neurodevelopmental effects exist four most commonly used AEDs. This initial report focuses on incidence...
Folic acid taken in early pregnancy reduces risks for delivering offspring with several congenital anomalies. The mechanism by which folic risk is unknown. Investigations into genetic variation that influences transport and metabolism of folate will help fill this data gap. We focused on 118 SNPs involved metabolism. Using from a California population-based registry, we investigated whether spina bifida or conotruncal heart defects were influenced single nucleotide polymorphisms (SNPs)...
The folate pathway plays a crucial role in the regeneration and repair of adult CNS after injury. Here, we have shown rodents that such occurs at least part through DNA methylation. In animals with combined spinal cord sciatic nerve injury, folate-mediated axon was found to depend on injury-related induction high-affinity receptor 1 (Folr1). activity dependent its activation by enzyme dihydrofolate reductase (Dhfr) functional methylation cycle. effect afferent neurons biphasic dose...
Folic acid is known to reduce risk of neural tube defects (NTDs). Even so, NTDs continue occur despite individual supplementation or population fortification with folic acid. We investigated other nutrients related one-carbon metabolism that may affect NTD risk.This prospective study included data from more than 180,000 pregnant women in California 2003 through 2005. Midpregnancy serum specimens were linked delivery information regarding the presence a NTD, another structural malformation,...
To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure.The NEAD Study is an ongoing prospective observational multicenter study, which enrolled pregnant women epilepsy on AED monotherapy (1999-2004) determine if differential long-term neurodevelopmental effects exist across 4 commonly used AEDs (carbamazepine, lamotrigine, phenytoin, or valproate). The primary outcome IQ 6 of age. Planned analyses were conducted using Bayley...