A5058706505- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Pharmaceutical studies and practices
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Psychosomatic Disorders and Their Treatments
- Fetal and Pediatric Neurological Disorders
- Migraine and Headache Studies
- Neonatal and fetal brain pathology
- COVID-19 and Mental Health
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
- Long-Term Effects of COVID-19
- Traumatic Brain Injury Research
- Alcoholism and Thiamine Deficiency
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Neurological Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Vaccine Coverage and Hesitancy
- Parkinson's Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Cardiovascular Health and Risk Factors
- Myasthenia Gravis and Thymoma
University of Hawaiʻi at Mānoa
2013-2025
Hawaii Pacific University
2017-2024
Brain (Germany)
2024
University of California, Los Angeles
2024
University of Hawaii System
2022-2023
Neurology, Inc
2023
National Institutes of Health
1999-2021
Massachusetts General Hospital
2021
The University of Adelaide
2018
Wichita State University
2007-2012
Summary Worldwide, about 65 million people are estimated to have epilepsy. Epidemiologic studies necessary define the full public health burden of epilepsy; set and care priorities; provide information needed for prevention, early detection, treatment; identify education service needs; promote effective support programs with However, different definitions epidemiologic methods complicate tasks these their interpretations comparisons. The purpose this document is consistency in an effort...
To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure.The NEAD Study is an ongoing prospective observational multicenter study, which enrolled pregnant women epilepsy on AED monotherapy (1999-2004) determine if differential long-term neurodevelopmental effects exist across 4 commonly used AEDs (carbamazepine, lamotrigine, phenytoin, or valproate). The primary outcome IQ 6 of age. Planned analyses were conducted using Bayley...
A Phase 3 open-label safety study (NCT02721069) evaluated long-term of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters.Patients were 6-65 years old diagnosed clusters despite stable antiseizure medications. The treatment period was 12 months, visits at Day 30 every 60 days thereafter, after which could elect to continue. Doses based on age weight. Seizure information recorded diaries. Treatment-emergent adverse events (TEAEs), irritation, olfactory...
<h3>Introduction/purpose</h3> Flow-diverting Pipeline stents are commonly used for endovascular treatment of cerebral aneurysms but can be associated with delayed ipsilateral intracerebral hemorrhage. Although intra-aneurysmal hemodynamic changes have been studied, parent vessel and intracranial hemodynamics after stenting unknown. Here, we examine the impact on artery distal hemodynamics. <h3>Materials methods</h3> Records patients internal carotid treated at our institution were...
Importance Many patients with focal epilepsy experience seizures despite treatment currently available antiseizure medications (ASMs) and may benefit from novel therapeutics. Objective To evaluate the efficacy safety of XEN1101, a small-molecule selective Kv7.2/Kv7.3 potassium channel opener, in focal-onset (FOSs). Design, Setting, Participants This phase 2b, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging adjunctive trial investigated XEN1101 over an 8-week period...
Survival after an Alzheimer's disease (AD) diagnosis is vital for patients, their families, caregivers, and healthcare providers. Hawaii, known its diverse ethnic population, exhibits significant racial health disparities. This study examined racial/ethnic socioeconomic disparities in AD survival Hawaii developed machine learning models to predict overall using Medicare data. Nine years of data were utilized gather information on development age 65, following patients capture all-cause or...
The drug-resistant epilepsy associated with Lennox-Gastaut syndrome (LGS) has a long-term effect on patients and is difficult to treat conventional pharmacological nonpharmacological therapies. Our objective demonstrate that adjunctive vagus nerve stimulation (VNS) can help manage the seizures LGS. CORE-VNS (NCT03529045) prospective, multicenter, multinational observational study collect data seizure nonseizure outcomes following treatment VNS. Participants were identified as having...
In the Phase 3 MycarinG study (NCT03971422), six once-weekly subcutaneous infusions of rozanolixizumab significantly improved myasthenia gravis (MG)-specific outcomes versus placebo in patients with acetylcholine receptor or muscle-specific tyrosine kinase autoantibody-positive generalized MG (gMG). Following completion MycarinG, could enroll open-label extension MG0004 (NCT04124965) to receive chronic weekly rozanolixizumab. Patients were re-randomized 1:1 7 10 mg/kg for up 52 infusions....
To characterize the cognitive deficits in children with gelastic seizures and hypothalamic hamartoma investigate relationship of seizure severity to abilities.Eight completed a neuropsychological battery standardized age-normed tests, including Woodcock-Johnson Psycho-Educational Battery-Revised: Tests Cognitive Ability, Peabody Picture Vocabulary Test-III, initial-letter word fluency measure.All displayed deficits, ranging from mild severe. Gelastic/complex partial was correlated broad...
Fludeoxyglucose F 18 positron emission tomography ((18)F-FDG-PET) can detect focal metabolic abnormalities ipsilateral to the seizure focus in 80% of patients with temporal lobe epilepsy (TLE). Regions outside epileptogenic zone also be affected. We hypothesized that these remote regions might show altered metabolism, tending return toward normal values, after surgery.Interictal preoperative and postoperative (18)F-FDG-PET metabolism were compared refractory TLE. Based on pathological...
Summary: Purpose: Hypothalamic hamartomas (HHs) have been associated with uncontrolled seizures, and aggressive therapy including surgery is often recommended. However, some patients, particularly those other findings Pallister‐Hall syndrome (PHS), a more benign course. Methods: Thirty‐seven of 40 PHS patients 16 isolated HH had lesion confirmed on magnetic resonance imaging (MRI). Records for all were reviewed the following information: presence age at seizure onset, type, frequency, number...
Objective An exploratory analysis from a long-term, phase 3, open-label, repeat-dose safety study of diazepam nasal spray for acute treatment seizure clusters assessed the use second dose up to 24 hours after initial and effectiveness in potentially reducing number seizures. Methods Seizures doses were recorded diaries. Results Of 175 patients enrolled, 163 received ≥1 included population; those total 4390 3853 clusters. Less than half these used least once during (79 [48.5%]), with 485...
Abstract Objective To characterize efficacy, safety/tolerability, and pharmacokinetics of padsevonil (PSL) administered concomitantly with ≤3 antiseizure medications (ASMs) for observable focal seizures in adults drug‐resistant epilepsy two multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group trials. Methods The phase 2b dose‐finding trial (EP0091/NCT03373383) randomized patients 1:1:1:1:1 to PSL 50/100/200/400 mg or placebo twice daily (b.i.d.). 3 efficacy...
Patients with psychogenic non-epileptic seizures (PNES) experience significant morbidity and early mortality, secondary to delayed diagnosis. Better characterizing risk factors exploring how PNES differentially affects sex racial strata may facilitate earlier diagnosis.From a Hawai'i neuroscience institution, 101 patients were investigated in relation sociodemographic medical comorbidities. Cases compared 202 sex-, age-, race-matched controls-representing neurological disorders (general...
Alprazolam administered via the Staccato® breath-actuated device is delivered into deep lung for rapid systemic exposure and a potential therapy epileptic seizure termination (REST). We conducted an inpatient study (ENGAGE-E-001 [NCT03478982]) in patients with stereotypic episodes prolonged or repetitive seizures to determine whether Staccato alprazolam rapidly terminates small observed population after administration under direct supervision.
<b><i>Objective:</i></b> To investigate the effect of vigabatrin (VGB; γ-vinyl γ-aminobutyric acid [GABA]), a selective irreversible GABA-transaminase inhibitor, on cerebral metabolic rate for glucose (CMRGlc) and blood flow (CBF) measured with <sup>18</sup>F-fluorodeoxyglucose (FDG) PET <sup>15</sup>O water PET. <b><i>Background:</i></b> Antiepileptic drugs (AEDs) reduce CMRGlc to varying degrees. Phenobarbital causes mean decrease 30 40%. Phenytoin, carbamazepine (CBZ), valproate (VPA)...