A5001529213- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Sleep and related disorders
- Pharmacological Effects and Toxicity Studies
- Parkinson's Disease Mechanisms and Treatments
- Ion channel regulation and function
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Infectious Encephalopathies and Encephalitis
- Functional Brain Connectivity Studies
- Neurological and metabolic disorders
- Photoreceptor and optogenetics research
- Transcranial Magnetic Stimulation Studies
- Autoimmune Neurological Disorders and Treatments
- Hemispheric Asymmetry in Neuroscience
- Advanced MRI Techniques and Applications
- Pregnancy and Medication Impact
- Attention Deficit Hyperactivity Disorder
Georgetown University
2016-2025
Deleted Institution
2023
MedStar Georgetown University Hospital
2021-2022
Georgetown University Medical Center
2009-2019
MedStar Health
2012
Keimyung University Dongsan Medical Center
2012
Georgetown-Howard Universities Center for Clinical and Translational Science
2012
Keimyung University
2012
University of Florida
2007
National Institute of Neurological Disorders and Stroke
2006
To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure.The NEAD Study is an ongoing prospective observational multicenter study, which enrolled pregnant women epilepsy on AED monotherapy (1999-2004) determine if differential long-term neurodevelopmental effects exist across 4 commonly used AEDs (carbamazepine, lamotrigine, phenytoin, or valproate). The primary outcome IQ 6 of age. Planned analyses were conducted using Bayley...
Obstructive sleep apnea (OSA) and chronic insomnia are two common disorders both considered independent risk factors for heart disease. The aim of this study was to investigate the prevalence comorbid with OSA compare its clinical characteristics those without insomnia. Patients who visited tertiary university hospital centers were screened. Those a diagnosis using polysomnography divided into groups based on their scores Korean version Insomnia Severity Index (ISI-K): (OSA+I) (ISI-K score ≥...
Summary: Purpose: We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. investigated conditions under which BPS is more likely to suppress ADs. Methods: analyzed parameters altering effectiveness on 200 ADs in seven patients with implanted subdural electrodes. Results: The odds BPSs stopping was 8.6 times greater at primary sites (directly stimulated electrodes) than secondary (adjacent (p = 0.016). applied...
The relative effects of levetiracetam (LEV) and carbamazepine (CBZ) on cognitive neurophysiologic measures are uncertain.The LEV CBZ were compared in healthy adults using a randomized, double-blind, two-period crossover design. Outcome included 11 standard neuropsychological tests the score from cognitive-neurophysiologic test attention memory. Evaluations conducted at screening, baseline pre-drug treatment, end each maintenance phase (4 weeks), washout period after drug treatment.A total 28...
Background: A Korean family had distinctive clinical and neuroimaging features carried the same genetic mutation that was found in a previously described Japanese kindred with autosomal dominant nocturnal frontal lobe epilepsy.Objective: To describe first epilepsy.Methods: Members of large family, including 9 affected individuals from 3 generations, underwent comprehensive genetic, clinical, electroencephalographic, neuropsychological, evaluation.Affected members were tested for possible...
The drug-resistant epilepsy associated with Lennox-Gastaut syndrome (LGS) has a long-term effect on patients and is difficult to treat conventional pharmacological nonpharmacological therapies. Our objective demonstrate that adjunctive vagus nerve stimulation (VNS) can help manage the seizures LGS. CORE-VNS (NCT03529045) prospective, multicenter, multinational observational study collect data seizure nonseizure outcomes following treatment VNS. Participants were identified as having...
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The loss of more than half the number GABA A receptors yet lack pronounced phenotype in mice lacking gene for α1 subunit is somewhat paradoxical. We explored role tonic receptor-mediated current as a target compensatory regulation knock-out (−/−) mice. 62% increase was observed cerebellar granule cells (CGCs) −/− compared with wild-type (+/+) along 67% baseline variance. Examination whole-cell currents evoked by low concentrations and 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol suggested...
There is growing evidence pointing at glymphatic system dysfunction in diseases with circadian disruption, such as sleep disorders. Lower diffusivity the direction of perivascular space has been shown several neurological and sleep-related disorders; however, its role restless legs syndrome (RLS) unclear. We hypothesized that similarly, RLS decreased. Here, we aimed to evaluate functionality patients RLS, compare it healthy controls, analyze correlation between function clinical characteristics.
ABSTRACT: We investigated the effects of transcranial alternating stimulation (tACS) in patients with insomnia. Nine chronic insomnia underwent two in-laboratory polysomnography, 2 weeks apart, and were randomized to receive tACS either during first or second study. The was applied simultaneously bilaterally at F3/M1 F4/M2 electrodes (0.75 mA, 0.75 Hz, 5-minute). Sleep onset latency wake after sleep dropped on night but they did not reach statistical significance; however, there significant...
Fatal familial insomnia (FFI) is a rare prion disease commonly inherited in an autosomal dominant pattern from mutation the PRioN Protein (PRNP) gene. Hashimoto's encephalopathy (HE) characterised by associated with antithyroid peroxidase (TPO) or antithyroglobulin (Tg) antibodies. These two conditions characteristically have differing clinical presentations dramatically different course and outcomes. Here, we present case of FFI mimicking HE. A woman her 50s presented worsening confusion,...