A5076067769- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Pregnancy and Medication Impact
- Neuroscience and Neuropharmacology Research
- Psychosomatic Disorders and Their Treatments
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury Research
- Maternal Mental Health During Pregnancy and Postpartum
- Neurological disorders and treatments
- Long-Term Effects of COVID-19
- EEG and Brain-Computer Interfaces
- Trigeminal Neuralgia and Treatments
- Ion channel regulation and function
- Cerebrospinal fluid and hydrocephalus
- Pregnancy and preeclampsia studies
- Amyotrophic Lateral Sclerosis Research
- Cardiac electrophysiology and arrhythmias
- Spinal Dysraphism and Malformations
- Thermal Regulation in Medicine
- Healthcare cost, quality, practices
- Neurological diseases and metabolism
- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Cancer Risks and Factors
- Electrolyte and hormonal disorders
Wake Forest University
2009-2024
Stanford University
2019-2024
Emory University
2019-2024
University of Southern California
2019-2024
University of Minnesota
2019-2024
Piedmont University
2024
Pennine Acute Hospitals NHS Trust
2024
Northwestern University
2019-2023
Minnesota Epilepsy Group
2019-2022
Northwell Health
2022
Summary: While undergoing video‐EEG monitoring, a 20‐year‐old woman had 56‐second convulsive seizure, after which she developed persistent apnea. The rhythm of the electrocardiogram complexes was unimpaired for approximately 10 seconds, it gradually and progressively slowed until stopped 57 seconds later. Evaluation successful cardiorespiratory resuscitation showed no evidence airway obstruction or pulmonary edema. patient previous cardio‐respiratory arrest complex partial seizure without...
To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure.The NEAD Study is an ongoing prospective observational multicenter study, which enrolled pregnant women epilepsy on AED monotherapy (1999-2004) determine if differential long-term neurodevelopmental effects exist across 4 commonly used AEDs (carbamazepine, lamotrigine, phenytoin, or valproate). The primary outcome IQ 6 of age. Planned analyses were conducted using Bayley...
Among women with epilepsy, studies regarding changes in seizure frequency during pregnancy have been limited by the lack of an appropriate nonpregnant comparator group to provide data on natural course both groups.
<h3>Importance</h3> The neurodevelopmental risks of fetal exposure are uncertain for many antiseizure medications (ASMs). <h3>Objective</h3> To compare children at 2 years age who were born to women with epilepsy (WWE) vs healthy and assess the association maximum ASM in third trimester subsequent cognitive abilities among WWE. <h3>Design, Setting, Participants</h3> Maternal Outcomes Neurodevelopmental Effects Antiepileptic Drugs (MONEAD) study is a prospective, observational, multicenter...
Importance Many patients with focal epilepsy experience seizures despite treatment currently available antiseizure medications (ASMs) and may benefit from novel therapeutics. Objective To evaluate the efficacy safety of XEN1101, a small-molecule selective Kv7.2/Kv7.3 potassium channel opener, in focal-onset (FOSs). Design, Setting, Participants This phase 2b, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging adjunctive trial investigated XEN1101 over an 8-week period...
To examine occurrence of severe adverse fetal outcomes (SAO), including loss and major congenital malformations (MCMs), in pregnant women with epilepsy (PWWE) vs healthy (HPW).
Neurodevelopmental effects of fetal antiseizure medication (ASM) exposure on creativity and executive functions are poorly understood. We previously found valproate to adversely affect measures functions. In this study, we examine newer ASMs these in children women with epilepsy (WWE) compared healthy (HW).
Migraine affects people of all races and both sexes. Migraineurs suffer financial losses impaired quality life. Recent progress in the treatment migraine has not been made readily available to who condition.To assess outpatient health care delivery patterns for sufferers United States.National Ambulatory Medical Care Survey data from 1990 1998 was used demographics patients seen with a diagnosis migraine, types physicians they saw, medications treat migraine.Women accounted 79% visits...
To assess the efficacy and safety of eslicarbazepine acetate (ESL) monotherapy.This post hoc pooled analysis 2 randomized double-blind studies (093-045 -046) included adults with partial-onset seizures medically uncontrolled by 1 or antiepileptic drugs (AEDs). Following baseline period (8 weeks), eligible patients were 2:1 to receive ESL 1,600 mg 1,200 once daily for 18 weeks; primary endpoint was study exit meeting predefined criteria (signifying worsening seizure control). In each study,...
The association of fetal exposure to antiseizure medications (ASMs) with outcomes in childhood are not well delineated.
Summary: Purpose: To determine the frequency of recording epileptiform discharges (EDs) in patients without epilepsy community and to assess their risk seizure disorders subsequently developing. Methods: We identified all outpatient inpatient EEGs that were recorded persons residing Rochester, Minnesota, from 1979 1988. Patients with a history unprovoked before index EEG excluded. Periodic lateralized EDs (PLEDs) not evaluated, because well‐established association disorders. Results: Five...
Importance Antiseizure medications (ASMs) are potential teratogens commonly prescribed for multiple indications. ASM fetal exposure can impair neurodevelopment. Folate improves pregnancy outcomes, but higher doses may pose risks. Objectives To compare the outcomes of 6-year-old children women with epilepsy (WWE) vs those healthy (HW), and assess association to third-trimester exposures. Design, Setting, Participants After informed consent, pregnant WWE HW were enrolled from 2012 through 2016...
To survey all US medical school clerkship directors (CDs) in neurology and to compare results from a similar 2005.A was developed by work group of the American Academy Neurology Undergraduate Education Subcommittee, sent CDs listed database. Comparisons were made 2005 survey.Survey response rate 73%. required 93% responding schools. Duration clerkships 4 weeks 74% 3 11%. Clerkships taken third year 56%, or fourth 19%, 12%. Clerkship duration 2012 slightly shorter than (fewer ≥4 weeks, p =...
To determine whether growth measures at birth differ between offspring of pregnant women with epilepsy and healthy women.The Maternal Outcomes Neurodevelopmental Effects Antiepileptic Drugs (MONEAD) study is a National Institutes Health-funded, prospective, observational, multicenter investigation pregnancy outcomes for mothers their infants. Between 2012 2016, were enrolled 20 US centers. Pregnant exposed to various antiepileptic drugs. The main outcome measure was small gestational age...
Deep brain stimulation (DBS) of the hippocampus is proposed for enhancement memory impaired by injury or disease. Many pre-clinical DBS paradigms can be addressed in epilepsy patients undergoing intracranial monitoring seizure localization, since they already have electrodes implanted areas interest. Even though usually not a disorder targeted DBS, studies nevertheless model other memory-impacting disorders, such as Traumatic Brain Injury (TBI). Human Phase II invasive intractable were with...
A 50-year-old woman with a progressive neurologic illness clinically resembling amyotrophic lateral sclerosis had Pick9s disease verified at autopsy. This case represents another example of in which the early manifestations were not those dementia. patient also showed some unusual histopathologic features, including degeneration substantia nigra and occasional "compound Pick bodies."
Breastfeeding has important health benefits for both mother and child. We characterize breastfeeding initiation duration in mothers with epilepsy relative to control a large prospective cohort.The Maternal Outcomes Neurodevelopmental Effects of Antiepileptic Drugs study is prospective, multicenter observational, US cohort study. Pregnant individuals without epilepsy, aged 14-45 years, were enrolled between December 19, 2012, February 11, 2016. Exclusion criteria included intelligence...
This study seeks to understand how sleep is affected in pregnant women with epilepsy (WWE) relative healthy during pregnancy and postpartum nonpregnant WWE comparative periods. Sleep affects maternal health mood pregnancy. Maternal disturbances are related poor fetal growth increased deaths. Epilepsy the most common neurologic condition disruption can worsen epileptic seizures. The interplay between epilepsy, pregnancy, poorly understood.The Outcomes Neurodevelopmental Effects of...
Summary Objective To evaluate the influence of prior use carbamazepine ( CBZ ) and other antiepileptic drugs AED s) with a putatively similar mechanism action (inhibition voltage‐gated sodium channels; VGSC on seizure outcomes tolerability when converting to eslicarbazepine acetate ESL ), using data pooled from 2 controlled conversion‐to‐ monotherapy trials (studies: 093‐045, 093‐046). Methods Adults treatment‐resistant focal (partial‐onset) seizures were randomized 2:1 1600 or 1200 mg once...
Abstract Life‐threatening myoclonus developed in a patient following inadvertent intrathecal usage of 60% diatrizoate meglumine. Rhabdomyolysis and myoglobinuria occurred. The was successfully treated with midazolam vecuronium complete recovery