A5066707901- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Pregnancy and Medication Impact
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Maternal Mental Health During Pregnancy and Postpartum
- Metabolism and Genetic Disorders
- Electrolyte and hormonal disorders
- Hemoglobinopathies and Related Disorders
- Retinal Diseases and Treatments
- Folate and B Vitamins Research
- Cardiovascular Syncope and Autonomic Disorders
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Moyamoya disease diagnosis and treatment
- Retinopathy of Prematurity Studies
- Neurological Complications and Syndromes
- EEG and Brain-Computer Interfaces
- Cell Adhesion Molecules Research
- Genomics and Rare Diseases
- Breastfeeding Practices and Influences
- Medical research and treatments
- Migraine and Headache Studies
- Zebrafish Biomedical Research Applications
Brigham and Women's Hospital
2015-2025
Harvard University
2014-2024
Stanford University
2017-2024
University of Southern California
2022-2024
Emory University
2018-2024
University of Toronto
2024
University of Minnesota
2024
Piedmont University
2024
GTx (United States)
2023
Northwestern University
2022-2023
The mammalian retina contains six major cell types, several of which are divided into multiple molecularly and morphologically distinct subtypes. To understand how subtype diversity arises during development, we focused on amacrine interneurons in the mouse retina; approximately 30 subtypes have been identified mammals. We used antibody markers to identify two main subsets--GABAergic glycinergic--and further subdivided these groups smaller subsets based expression neurotransmitter...
To characterize the magnitude and time course of pregnancy-related clearance changes for different antiepileptic drugs (AEDs): levetiracetam, oxcarbazepine, topiramate, phenytoin, valproate. A secondary aim was to determine if a decreased AED serum concentration associated with increased seizure frequency.
During pregnancy in women with epilepsy, lower blood concentrations of antiseizure medications can have adverse clinical consequences.
Single progenitors can give rise to any and all of the main retinal cell types: photoreceptors, interneurons (horizontal, bipolar, amacrine cells), ganglion cells (RGCs), glia. Many these types are divisible into multiple functionally, structurally, molecularly distinct subtypes (e.g., ∼25 for RGCs). It remains unknown when how become committed generate such subtypes. Here, we determine origin RGCs that respond selectively vertical motion express cadherin 6 ( cdh6 ). Using Cre...
In pregnancy, it is important to balance the risks of uncontrolled epileptic seizures mother and fetus against potential teratogenic effects antiseizure medications. Data are limited on pregnancy outcomes among patients taking lacosamide (LCM), particularly when taken as monotherapy. The objective this analysis was evaluate LCM-exposed pregnancies.
Neurodevelopmental effects of fetal antiseizure medication (ASM) exposure on creativity and executive functions are poorly understood. We previously found valproate to adversely affect measures functions. In this study, we examine newer ASMs these in children women with epilepsy (WWE) compared healthy (HW).
<h3>Background and Objectives</h3> Assess the incidence factors associated with major depressive episodes (MDEs) symptoms of depression anxiety during pregnancy postpartum periods in pregnant women epilepsy (PWWE) compared healthy (HPW) nonpregnant (NPWWE) comparable timeframes. Previous studies have reported higher rates without epilepsy. However, MDE using a structured interview has not been directly control groups, comparison role remain ambiguous. <h3>Methods</h3> The Maternal Outcomes...
The association of fetal exposure to antiseizure medications (ASMs) with outcomes in childhood are not well delineated.
To assess whether increased seizure frequency during pregnancy and postpartum is influenced by epilepsy type, location, antiseizure medications.Clinical data were collected in a longitudinal prospective database of pregnant women with at Brigham Women's Hospital. Within each individual participant, baseline was calculated for the 9 months before conception, or period determined. Seizure 4-week interval pregnancy. Generalized estimating equations logistic regression applied.Ninety-nine...
We evaluated the occurrence and distribution of patterns catamenial epilepsy in a heterogenous cohort women with on no hormonal therapies, enrolled prospective, observational study. The primary aim study was pregnancy rate prior reproductive problems. In this analysis, we included who recorded one or more menstrual cycles seizures. measured progesterone concentrations for to three cycles. defined as twofold greater average daily seizure frequency around menstruation (C1), ovulation (C2),...
Importance Antiseizure medications (ASMs) are potential teratogens commonly prescribed for multiple indications. ASM fetal exposure can impair neurodevelopment. Folate improves pregnancy outcomes, but higher doses may pose risks. Objectives To compare the outcomes of 6-year-old children women with epilepsy (WWE) vs those healthy (HW), and assess association to third-trimester exposures. Design, Setting, Participants After informed consent, pregnant WWE HW were enrolled from 2012 through 2016...
Stroke-like migraine attacks after radiation therapy (SMART) syndrome is characterized by transient, focal neurologic symptoms occurring years radiation,1 with or regional cortical thickening and gadolinium enhancement on MRI in the area of brain exposed to radiation. The pathophysiology not well-understood. We present 2 patients recurrent SMART increased cerebral blood volume affected regions abnormal vascular reactivity transcranial Doppler ultrasound, suggesting a potential mechanism.
Breastfeeding has important health benefits for both mother and child. We characterize breastfeeding initiation duration in mothers with epilepsy relative to control a large prospective cohort.The Maternal Outcomes Neurodevelopmental Effects of Antiepileptic Drugs study is prospective, multicenter observational, US cohort study. Pregnant individuals without epilepsy, aged 14-45 years, were enrolled between December 19, 2012, February 11, 2016. Exclusion criteria included intelligence...
Epilepsy education has been transformed over the past 2 decades, leading to a need for structured formative assessment tools. The American Society developed Fellowship In-Training Examination (EpiFITE) provide high-quality fellows, stimulate program improvement, and guide future learning teaching. aim of this study was explore validity evidence EpiFITE in meeting these goals.
Stretch syncope is a distinct entity characterized by transient alteration in awareness (TAA) induced neck hyperextension during stretching. Few cases of stretch have been reported the literature. Nevertheless, this highly relevant diagnosis as it can be easily mistaken for epilepsy number reasons. These include stereotypical motor activity associated with events, development ictal tachycardia, and presence rhythmic/semirhythmic slowing on EEG context cerebral hypoperfusion. We present case...
Emanuela P, Kay JN, Sanes JR. 2009. Birthdays of retinal amacrine cell subtypes are systematically related to their molecular identity and soma position. J Comp Neurol 517:737–750. In the above-referenced article, last name an author was omitted. All names reprinted here as they should have appeared in printed version article. The online files original article been updated reflect this correction. Publisher regrets error.