A5017253540- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Pregnancy and Medication Impact
- Genomics and Rare Diseases
- Neonatal and fetal brain pathology
- Genetics and Neurodevelopmental Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Pregnancy and preeclampsia studies
- Heart Rate Variability and Autonomic Control
- Obstructive Sleep Apnea Research
- Schizophrenia research and treatment
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Neurological disorders and treatments
- Traumatic Brain Injury Research
- Maternal Mental Health During Pregnancy and Postpartum
- Migraine and Headache Studies
- Metabolism and Genetic Disorders
- Psychosomatic Disorders and Their Treatments
- Cardiac Arrest and Resuscitation
- Multiple Sclerosis Research Studies
- Mitochondrial Function and Pathology
- Time Series Analysis and Forecasting
Austin Health
2017-2025
Monash University
2018-2025
Alfred Health
2018-2025
The Royal Melbourne Hospital
2016-2025
The University of Melbourne
2016-2025
Austin Hospital
2021-2024
The Alfred Hospital
2018-2024
University of Miami
2020-2024
New York University
2021-2024
Monash Medical Centre
2022
Because seizures originate from different pathological substrates, the question arises of whether distinct or similar mechanisms underlie seizure generation across pathologies. Better defining intracranial electroencephalographic morphological patterns at seizure-onset could improve understanding such mechanisms. To this end, we investigated associated with epileptogenic lesions, and defined high-frequency oscillation correlates each pattern. We analysed representative types 33 consecutive...
<h3>Objective</h3> To evaluate the use of interictal high-frequency oscillations (HFOs) in epilepsy surgery for prediction postsurgical seizure outcome a prospective multicenter trial. <h3>Methods</h3> We hypothesized that seizure-free could be expected patients whom surgical planning included majority HFO-generating brain tissue while poor only few such areas were planned to resected. Fifty-two from 3 tertiary centers during 1-year period. Ripples (80–250 Hz) and fast ripples (250–500...
Early posttraumatic seizures (EPS) that may occur following a traumatic brain injury (TBI) are associated with poorer outcomes and development of epilepsy (PTE).To evaluate risk factors for EPS, morbidity mortality, contribution to PTE.Data were collected from an Australian registry-based cohort study adults (age ≥18 years) moderate severe TBI January 2005 December 2019, 2-year follow-up. The statewide trauma registry, conducted on opt-out basis in Victoria (population 6.5 million), had 15...
Importance Women with epilepsy (WWE) require treatment antiseizure medications (ASMs) during pregnancy, which may be associated an increased risk of major congenital malformations (MCMs) in their offspring. Objective To investigate the prevalence MCMs after prenatal exposure to 8 commonly used ASM monotherapies and changes MCM over time. Design, Setting, Participants This was a prospective, observational, longitudinal cohort study conducted from June 1999 October 2022. Since 1999, physicians...
Adverse effects (AEs) of antiepileptic drugs (AEDs) are a major impediment to optimal dosing for seizure control. Better understanding clinical properties AEs is prerequisite systematic research their neurobiological underpinnings. This study aimed define specific patterns AE occurrence and determine relevance based on association with subjective health status.Two hundred subjects epilepsy completed validated self-report assessments, including the Event Profile (AEP) Quality Life in Epilepsy...
Summary Purpose Removal of areas generating high‐frequency oscillations ( HFO s) recorded from the intracerebral electroencephalography iEEG ) patients with medically intractable epilepsy has been found to be correlated improved surgical outcome. However, whether differences exist according type is largely unknown. We performed a comparative assessment impact removing ‐generating tissue on outcome between temporal lobe TLE and extratemporal ETLE ). also assessed relationship extent resection...
Abstract Since 1992, the Eilat Conferences have provided a forum for all stakeholders in epilepsy community to appraise latest data on new antiepileptic drugs and emergency seizure treatments, including, recent years, updates progress with development of novel monitoring therapeutic devices. Because COVID‐19 pandemic, Fifteenth Conference New Antiepileptic Drugs Devices (EILAT XV) was held as fully virtual conference July 27‐30, 2020 sessions August 3, devices, attended during 5 days by...
<h3>Objective</h3> To investigate the hypothesis that patients diagnosed with psychogenic nonepileptic seizures (PNES) on video-EEG monitoring (VEM) have increased mortality by comparison to general population. <h3>Methods</h3> This retrospective cohort study included evaluated in VEM units of 3 tertiary hospitals Melbourne, Australia, between January 1, 1995, and December 31, 2015. Diagnosis was based consensus opinion experienced epileptologists neuropsychiatrists at each hospital....
Abstract Introduction Many patients with cognitive and neuropsychiatric symptoms face diagnostic delay misdiagnosis. We investigated whether cerebrospinal fluid (CSF) neurofilament light (NfL) total‐tau (t‐tau) could assist in the clinical scenario of differentiating neurodegenerative (ND) from psychiatric disorders (PSY), rapidly progressive disorders. Methods Biomarkers were examined specialist services (ND PSY) a national Creutzfeldt‐Jakob registry (Creutzfeldt‐Jakob disease [CJD]...
Abstract For >30 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided a forum for discussion of advances in development new therapies seizures epilepsy. The EILAT XVII conference took place Madrid, Spain, May 5–8, 2024. Participants included basic scientists clinical investigators from industry academia, other health care professionals, representatives lay organizations. We summarize this article information treatments preclinical early discussed at conference....
The 17th Eilat Conference on New Antiepileptic Drugs and Devices took place in Madrid, Spain May 5-8, 2024. As usual, the core part of conference consisted presentations investigational drugs at various stages development for epilepsy-related indications. Summaries information compounds preclinical or early clinical are included an accompanying publication (Part I). In this article, we provide summaries five more advanced development, i.e. which some antiseizure activity individuals with...