A5066790544- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Treatment of Major Depression
- Sleep and Wakefulness Research
- Neural Networks and Applications
- Blind Source Separation Techniques
- Cognitive Science and Mapping
- Pain Management and Treatment
- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Atomic and Subatomic Physics Research
- Photoreceptor and optogenetics research
- Manufacturing Process and Optimization
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Augmented Reality Applications
- Distributed Control Multi-Agent Systems
Massachusetts General Hospital
2018-2024
Harvard University
2018-2024
Center for Neuro-Oncology
2021-2024
Montreal Neurological Institute and Hospital
2010-2019
McGill University
2010-2019
Mattel Children's Hospital
2018
John Wiley & Sons (United States)
2018
Hudson Institute
2018
University of Freiburg
2018
University Medical Center Utrecht
2009-2015
High-frequency oscillations (HFOs) in the intracerebral electroencephalogram (EEG) have been linked to seizure onset zone (SOZ). We investigated whether HFOs can delineate epileptogenic areas even outside SOZ by correlating resection of HFO-generating with surgical outcome.Twenty patients who underwent a for medically intractable epilepsy were studied. All had presurgical EEG (500Hz filter and 2,000Hz sampling rate), at least 12-month postsurgical follow-up, magnetic resonance imaging (MRI)....
In contrast to scalp EEG, our knowledge of the normal physiological intracranial EEG activity is scarce. This multicentre study provides an atlas human brain during wakefulness. Here we present results power spectra analysis Intracranial electrodes are placed in or on epilepsy patients when candidates for surgical treatment and non-invasive approaches failed sufficiently localize epileptic focus. Electrode contacts usually cortical regions showing activity, but some regions, at distance from...
High-frequency oscillations (HFOs) are a promising biomarker for the epileptogenic zone. It has not been possible, however, to differentiate physiological from pathological HFOs, and baseline rates of HFO occurrence vary substantially across brain regions. This project establishes region-specific normative values HFOs high-frequency activity (HFA).Intracerebral stereo-encephalographic recordings with channels displaying normal nonlesional tissue were selected 2 tertiary epilepsy centers....
<h3>Objective</h3> To evaluate the use of interictal high-frequency oscillations (HFOs) in epilepsy surgery for prediction postsurgical seizure outcome a prospective multicenter trial. <h3>Methods</h3> We hypothesized that seizure-free could be expected patients whom surgical planning included majority HFO-generating brain tissue while poor only few such areas were planned to resected. Fifty-two from 3 tertiary centers during 1-year period. Ripples (80–250 Hz) and fast ripples (250–500...
High-frequency oscillations (HFOs) can be recorded in epileptic patients with clinical intracranial EEG. HFOs have been associated seizure genesis because they occur the focus and during onset. are also found interictally, partly co-occurring spikes. We studied how influenced by antiepileptic medication occurrence, to improve understanding of pathophysiology meaning HFOs.Intracerebral depth EEG was sampled at 2,000 Hz 42 intractable focal epilepsy. Patients five or more usable nights...
Summary Purpose Removal of areas generating high‐frequency oscillations ( HFO s) recorded from the intracerebral electroencephalography iEEG ) patients with medically intractable epilepsy has been found to be correlated improved surgical outcome. However, whether differences exist according type is largely unknown. We performed a comparative assessment impact removing ‐generating tissue on outcome between temporal lobe TLE and extratemporal ETLE ). also assessed relationship extent resection...
Intraoperative electrocorticography (ECoG) can be used to delineate the resection area in epilepsy surgery. High-frequency oscillations (HFOs; 80-500 Hz) seem better biomarkers for epileptogenic tissue than spikes. We studied how HFOs and spikes combined pre- postresection ECoG predict surgical outcome different tailoring approaches.We, retrospectively, marked HFOs, divided into fast ripples (FRs; 250-500 (80-250 Hz), sampled at 2,048 Hz people with refractory focal epilepsy. defined four...
We studied whether residual high-frequency oscillations (80-500 Hz; ripples, 80-250 Hz), especially fast ripples (FRs, 250-500 in post-resection intraoperative electrocorticography (ECoG) predicted seizure recurrence comparison to interictal spikes and ictiform spike patterns.We studied, retrospectively, ECoG recorded at 2,048 Hz after resection a cohort of patients with refractory focal epilepsy. analyzed occurrence number FRs, spikes, patterns within the last minute each recording compared...
Intracranial depth macroelectrode recordings from patients with focal seizures demonstrate interictal and ictal high frequency oscillations (HFOs, 80-500 Hz). These HFOs are more frequent in the seizure-onset zone (SOZ) reported to be linked seizure genesis. We evaluated whether HFO activity changes a systematic way during preictal period.Fifteen minutes of intracranial electroencephalography (EEG) were seven consecutive well-defined SOZ. EEG was filtered at 500 Hz sampled 2,000 Hz. Ripples...
Abstract Ketamine produces antidepressant effects in patients with treatment-resistant depression, but its usefulness is limited by psychotropic side effects. thought to act via NMDA receptors and HCN1 channels produce brain oscillations that are related these Using human intracranial recordings, we found ketamine gamma prefrontal cortex hippocampus, structures previously implicated ketamine’s effects, a 3 Hz oscillation posteromedial cortex, proposed as mechanism for dissociative We...
Functional neuroimaging studies of epilepsy patients often show, at the time epileptic activity, deactivation in default mode network (DMN) regions, which is hypothesized to reflect altered consciousness. We aimed study metabolic and electrophysiological correlates these changes DMN regions. studied six that underwent scalp EEG-fMRI later stereotaxic intracerebral EEG (SEEG) sampling regions (posterior cingulate cortex, Pre-cuneus, inferior parietal lobule, medial prefrontal cortex...