A5023369964- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Advanced MRI Techniques and Applications
- Intensive Care Unit Cognitive Disorders
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Anesthesia and Sedative Agents
- Neonatal and fetal brain pathology
- Visual perception and processing mechanisms
- Atomic and Subatomic Physics Research
- Glioma Diagnosis and Treatment
- Diet and metabolism studies
- Neurobiology of Language and Bilingualism
- Heart Rate Variability and Autonomic Control
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac electrophysiology and arrhythmias
- Sleep and Wakefulness Research
- Anesthesia and Neurotoxicity Research
- Non-Invasive Vital Sign Monitoring
- Motor Control and Adaptation
- Intracranial Aneurysms: Treatment and Complications
University Medical Center Utrecht
2016-2025
Stichting Epilepsie Instellingen Nederland
2014-2024
Heidelberg University
2003-2024
University Hospital Heidelberg
2003-2024
Utrecht University
2013-2024
Nederlandse Vereniging voor Anesthesiologie
2024
University of Pavia
2020
Hospices Civils de Lyon
2020
Euro-Centrum
2019
Kempenhaeghe
2018
Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy.We report diagnoses made basis of resected specimens from 9523 patients who underwent epilepsy surgery in 36 centers 12 European countries over 25 years. Histopathological were determined through examination local hospitals (41%) or at German Neuropathology Reference Center Epilepsy Surgery (59%).The onset occurred before 18 years age 75.9%...
To test the hypothesis that prolonged motor recovery after long-term ventilation may be due to polyneuropathy and can foreseen at an early stage by electromyography (EMG).Cohort study with entry period of 18 months. Polyneuropathy was identified EMG studies in intensive care unit (ICU). During a 1-year follow-up, amount time recorded reach rehabilitation end point.The general ICU community hospital.Fifty patients younger than 75 years who were receiving mechanical for more 7 days.A point...
Epilepsy surgery requires precise localization of the epileptic source. EEG-correlated functional MRI (EEG-fMRI) is a new technique showing haemodynamic effects interictal epileptiform activity. This study assesses its potential added value in presurgical evaluation patients with complex source localization. Adult surgical candidates considered ineligible because an unclear focus and/or presumed multifocality on basis EEG underwent EEG-fMRI. Interictal discharges (IEDs) during fMRI were...
The neurophysiological underpinnings of functional magnetic resonance imaging (fMRI) are not well understood. To understand the relationship between fMRI blood oxygen level dependent (BOLD) signal and neurophysiology across large areas cortex, we compared task related BOLD change during simple finger movement to brain surface electric potentials measured on a similar spatial scale using electrocorticography (ECoG). We found that spectral power increases in high frequencies (65-95 Hz), which...
Intraoperative electrocorticography (ECoG) can be used to delineate the resection area in epilepsy surgery. High-frequency oscillations (HFOs; 80-500 Hz) seem better biomarkers for epileptogenic tissue than spikes. We studied how HFOs and spikes combined pre- postresection ECoG predict surgical outcome different tailoring approaches.We, retrospectively, marked HFOs, divided into fast ripples (FRs; 250-500 (80-250 Hz), sampled at 2,048 Hz people with refractory focal epilepsy. defined four...
We studied whether residual high-frequency oscillations (80-500 Hz; ripples, 80-250 Hz), especially fast ripples (FRs, 250-500 in post-resection intraoperative electrocorticography (ECoG) predicted seizure recurrence comparison to interictal spikes and ictiform spike patterns.We studied, retrospectively, ECoG recorded at 2,048 Hz after resection a cohort of patients with refractory focal epilepsy. analyzed occurrence number FRs, spikes, patterns within the last minute each recording compared...
Epilepsy surgery depends on reliable pre-surgical markers of epileptogenic tissue. The current gold standard is the seizure onset zone in ictal, i.e. chronic, electrocorticography recordings. Single pulse electrical stimulation can evoke epileptic, spike-like responses areas also recorded by electrocorticography. Recently, spontaneous pathological high-frequency oscillations (80–520 Hz) have been observed electrocorticogram that are related to epileptic spikes, but seem more specific for...
Summary Objective Children with rolandic spikes may or not have seizures, ranging from benign epilepsy to severe atypical epilepsy. We investigated whether ripples (80–250 Hz), superimposed on in surface electroencephalography ( EEG ), can differentiate between different entities. Methods In this cohort study we analyzed the studies of children without other magnetic resonance imaging MRI ) abnormalities. They were divided into following three groups: (1) but no epilepsy, (2) typical and (3)...
<h3>Objective</h3> To develop and prospectively evaluate a method of epileptic seizure detection combining heart rate movement. <h3>Methods</h3> In this multicenter, in-home, prospective, video-controlled cohort study, nocturnal seizures were detected by (photoplethysmography) or movement (3-D accelerometry) in persons with epilepsy intellectual disability. Participants >1 monthly major wore bracelet (Nightwatch) on the upper arm at night for 2 to 3 months. Major tonic-clonic, generalized...
Summary Objective In 2014 the European Union–funded E‐ PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed investigate current use of neuroimaging, electromagnetic source localization, imaging postprocessing procedures in participating centers. Methods A survey on clinical imaging, methods candidates distributed among 25 centers consortium. descriptive analysis performed, results were compared existing guidelines...
This study uses electrocorticography in humans to assess how alpha- and beta-band rhythms modulate excitability of the sensorimotor cortex during psychophysically-controlled movement imagery. Both displayed effector-specific modulations, tracked spectral markers action potentials local neuronal population, showed spatially systematic phase relationships (traveling waves). Yet, differed their anatomical functional properties, were weakly correlated, traveled along opposite directions across...
Abstract The structure of the human connectome develops from childhood throughout adolescence to middle age, but how these structural changes affect speed neuronal signaling is not well described. In 74 subjects, we measured latency cortico-cortical evoked responses across association and U-fibers calculated their corresponding transmission speeds. Decreases in conduction delays until at least 30 years show that communication into adulthood.
To determine whether highly epileptiform electrocorticographical discharge patterns occur in patients with glioneuronal tumors (GNTs) and focal cortical dysplasia (FCD) specific histopathological features are related to such patterns.The series consists of operated pharmacoresistant epilepsy because FCD or GNT between 1992 2003. Electrocorticography was reviewed for presence continuous spiking, bursts, recruiting discharges, sporadic spikes. Surgical specimens were the balloon cells,...
Brain-computer interfaces (BCIs) translate deliberate intentions and associated changes in brain activity into action, thereby offering patients with severe paralysis an alternative means of communication control over their environment. Such systems are not available yet, partly due to the high performance standard that is required. A major challenge development implantable BCIs identify cortical regions related functions individual can reliably consciously manipulate. Research predominantly...
Magnetoencephalography (MEG) is considered a useful tool for planning electrode placement chronic intracranial subdural electrocorticography (ECoG) in candidates epilepsy surgery or even as substitute ECoG. MEG recordings are usually interictal and therefore, at best, reflect the To estimate clinical value of MEG, it important to know how well reflects activity From 1998 2008, 38 ECoG underwent 151-channel recording 3D magnetic resonance imaging part their presurgical evaluation. Interictal...
<h3>Objective:</h3> To explore whether EEG and MRI abnormalities in the “healthy” hemisphere influence seizure cognitive outcome after functional hemispherectomy. <h3>Methods:</h3> This is a retrospective consecutive cohort study of 43 children who underwent hemispherectomy between 1994 2008. Results preoperative recordings were reviewed for existence (inter)ictal epileptic or background contralateral hemisphere. Preoperative MRIs reexamined unequivocal abnormalities. Postoperative status...