A5015775261- Cardiovascular Syncope and Autonomic Disorders
- Epilepsy research and treatment
- Heart Rate Variability and Autonomic Control
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Psychosomatic Disorders and Their Treatments
- Neuroscience of respiration and sleep
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Sleep and Wakefulness Research
- Obstructive Sleep Apnea Research
- Neonatal and fetal brain pathology
- Neurology and Historical Studies
- Transportation Planning and Optimization
- Neurological disorders and treatments
- Migraine and Headache Studies
- Blood Pressure and Hypertension Studies
- Autoimmune Neurological Disorders and Treatments
- Traffic control and management
- Peripheral Neuropathies and Disorders
- Ion channel regulation and function
- Traffic Prediction and Management Techniques
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
Stichting Epilepsie Instellingen Nederland
2016-2025
University College London
2016-2025
Leiden University
2015-2025
Leiden University Medical Center
2016-2025
National Hospital for Neurology and Neurosurgery
2013-2025
Epilepsy Society
2013-2024
UCL Biomedical Research Centre
2015-2024
University of Bologna
2024
New York University
2022
Université de Montréal
2022
This nationwide study gives a detailed description of the clinical features and long-term outcome anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis.We collected patients prospectively from October 2013, retrospectively samples sent to our laboratory January 2007. LGI1 antibodies were confirmed with both cell-based assay immunohistochemistry. Clinical information was obtained in interviews their relatives medical records. Initial MRI follow-up revised blindly. Neuropsychological...
Summary Purpose: Most people with epilepsy who die suddenly and whose death is attributed to sudden unexpected in (SUDEP) are found or by the bed for unknown reasons. We assessed whether those sleep‐related SUDEP were more likely have nocturnal seizures, seizure patterns (diurnal vs. nocturnal) differed from dying living controls epilepsy. Methods: Seizure a cohort of 154 died after autopsy conformed definition 616 classified as having “exclusively diurnal” “nocturnal seizures.” Comparisons...
<h3>Objective</h3> This nationwide cohort study evaluates seizure responses to immunotherapy and antiepileptic drugs (AEDs) in patients with anti-leucine-rich glioma-inactivated 1 (LGI1), anti-NMDA receptor (NMDAR), anti-gamma-aminobutyric-acid B (GABA<sub>B</sub>R) encephalitis. <h3>Methods</h3> Anti-LGI1, anti-NMDAR, anti-GABA<sub>B</sub>R encephalitis new-onset seizures were included. Medical information about disease course, AEDs immunotherapies used, effects, side effects collected....
To assess the clinical relevance of a positive voltage-gated potassium channel (VGKC) test in patients lacking antibodies to LGI1 and Caspr2.VGKC-positive were tested for Caspr2 antibodies. Patients both matched (1:2) VGKC-negative patients. Clinical paraclinical criteria used blindly determine evidence autoimmune inflammation groups. with an inconclusive VGKC titer analyzed same way.A total 1,455 by radioimmunoassay. Fifty-six positive, 50 whom available be included. Twenty-five had (n =...
Syncope is defined as transient loss of consciousness a result cerebral hypoperfusion. Electroencephalography during syncope shows either 'slow-flat-slow' or 'slow' pattern. The first believed to denote more severe Although the diagnosis vasovagal relies primarily on history taking, there limited evidence regarding relative importance various clinical features, and none that relate them severity electroencephalographic changes. aim this investigation was study symptoms, signs changes with 1...
Leucine‐rich glioma‐inactivated1 (LGI1) encephalitis is an antibody‐associated inflammation of the limbic area. An autoimmune etiology suspected but not yet proven. We performed human leukocyte antigen (HLA) analysis in 25 nontumor anti‐LGI1 patients and discovered a remarkably strong HLA association. HLA‐DR7 was present 88% compared to 19.6% healthy controls ( p = 4.1 × 10 −11 ). HLA‐DRB4 all 46.5% 1.19 −7 These findings support hypothesis. exploratory small group 4 tumor‐LGI1 patients. The...
<h3>Objective:</h3> To determine the consistency and facilitating cofactors of postictal generalized EEG suppression (PGES) >20 seconds after convulsive seizures (CS), a suggested predictor sudden unexpected death in epilepsy risk. <h3>Methods:</h3> We retrospectively reviewed video-EEG data people with ≥2 recorded CS. Presence duration PGES were assessed by 2 independent observers blinded to patient status. Intraindividual was determined correlations clinical characteristics analyzed...
<h3>Objective</h3> To develop and prospectively evaluate a method of epileptic seizure detection combining heart rate movement. <h3>Methods</h3> In this multicenter, in-home, prospective, video-controlled cohort study, nocturnal seizures were detected by (photoplethysmography) or movement (3-D accelerometry) in persons with epilepsy intellectual disability. Participants >1 monthly major wore bracelet (Nightwatch) on the upper arm at night for 2 to 3 months. Major tonic-clonic, generalized...
Sudden unexpected death in epilepsy (SUDEP) is a fatal complication of which brainstem spreading depolarization may play pivotal role, as suggested by animal studies. However, patiotemporal details occurring relation to seizures have not been investigated. In addition, little known about behavioural and neurophysiological features that discriminate spontaneous from non-fatal seizures. Transgenic mice carrying the missense mutation S218L α1A subunit Cav2.1 (P/Q-type) Ca2+ channels exhibit...
Head-up tilt test (TT) has been used for >50 years to study heart rate/blood pressure adaptation positional changes, model responses haemorrhage, assess orthostatic hypotension, and evaluate haemodynamic neuroendocrine in congestive failure, autonomic dysfunction, hypertension. During these studies, some subjects experienced syncope due vasovagal reflex. As a result, testing was incorporated into clinical assessment of when the origin unknown. Subsequently, experience supports diagnostic...
Background People with epilepsy are at increased risk for sudden death. The most prevalent cause of death in the general population is cardiac arrest (SCA) due to ventricular fibrillation (VF). SCA may contribute incidence people epilepsy. We assessed whether by determining among active a community-based study. Methods and Results This investigation was part Amsterdam Resuscitation Studies (ARREST) Netherlands. It designed assess population. All cases study area were identified matched...
<h3>Objectives:</h3> To provide a detailed semiology to aid the clinical recognition of psychogenic pseudosyncope (PPS), which concerns episodes apparent transient loss consciousness (TLOC) that mimic syncope. <h3>Methods:</h3> We analyzed all consecutive tilt-table tests from 2006 2012 showing proven PPS, i.e., TLOC had occurred without EEG changes or decrease in heart rate (HR) blood pressure (BP). baseline characteristics, video data, EEG, ECG, and continuous BP measurements on 1-second...
Vasovagal syncope (VVS) is a consistent, but infrequent (0.1%‐0.3%) complication of volunteer, whole blood donation. Given the large number donations, significant donors involved. Syncope occasionally leads to injury. Recent rigorous data collection and analysis have led association small donor donation factors with risk syncope. An time course reactions among approximately 500,000 suggests that there are three distinct periods for vasovagal before, during, after phlebotomy. This review...