A5019830309- CAR-T cell therapy research
- Cardiac electrophysiology and arrhythmias
- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 and healthcare impacts
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Ion channel regulation and function
- Epilepsy research and treatment
- Cancer Genomics and Diagnostics
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Biosimilars and Bioanalytical Methods
- Cytomegalovirus and herpesvirus research
- Childhood Cancer Survivors' Quality of Life
- Advancements in Semiconductor Devices and Circuit Design
- Silicon Carbide Semiconductor Technologies
- Biomedical Ethics and Regulation
- Integrated Circuits and Semiconductor Failure Analysis
- Neutropenia and Cancer Infections
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Causal Inference Techniques
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- COVID-19 Clinical Research Studies
- Cancer survivorship and care
Karolinska University Hospital
2024-2025
Karolinska Institutet
2024-2025
University of Amsterdam
2011-2024
Amsterdam University Medical Centers
2020-2024
Cancer Center Amsterdam
2022-2024
Lymphatic Education & Research Network
2023
Lymphoma Research Foundation
2023
Palmetto Hematology Oncology
2023
Amsterdam UMC Location University of Amsterdam
2011-2018
AimsHeterozygous mutations in KCNQ1 cause type 1 long QT syndrome (LQT1), a disease characterized by prolonged heart rate-corrected interval (QTc) and life-threatening arrhythmias. It is unknown why penetrance expressivity so variable between individuals hosting identical mutations. We aimed to study whether this can be explained single nucleotide polymorphisms (SNPs) KCNQ1's 3′ untranslated region (3′UTR).
COVID-19 is posing a significant threat to health in vulnerable patients, such as immunocompromised patients.For hematopoietic cell transplantation (HCT) recipients and patients with hematologic malignancies it known that leads severe morbidity high mortality compared the general population [1][2][3].For treated Chimeric Antigen Receptor T-cell (CAR-T-cell) therapy for B-cell however, descriptions of clinical course outcome are still limited small case series reports...
Background People with epilepsy are at increased risk for sudden death. The most prevalent cause of death in the general population is cardiac arrest (SCA) due to ventricular fibrillation (VF). SCA may contribute incidence people epilepsy. We assessed whether by determining among active a community-based study. Methods and Results This investigation was part Amsterdam Resuscitation Studies (ARREST) Netherlands. It designed assess population. All cases study area were identified matched...
Confusion developed in a 49-year-old woman with relapsed diffuse large B-cell lymphoma within days after she received CAR-T therapy. She had difficulty putting words together and was disoriented but no focal abnormalities noted during the neurologic examination.
The real-world results of chimeric antigen receptor T-cell (CAR-T) therapy for patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) substantially differ across countries. In the Netherlands, CAR-T tumorboard facilitates a unique nationwide infrastructure referral, eligibility assessment and data collection. aim this study was to evaluate outcomes axicabtagene ciloleucel (axi-cel) in Dutch population, including thus-far underreported effects on health-related quality life...
Abstract COVID-19 has been associated with high mortality in patients treated Chimeric Antigen Receptor (CAR) T-cell therapy for hematologic malignancies. Here, we investigated whether the outcome improved over time primary objective of assessing COVID-19-attributable Omicron period 2022 compared to previous years. Data this multicenter study were collected using MED-A and report forms developed by EBMT. One-hundred-eighty included analysis, 39 diagnosed 2020, 35 2021 106 2022. The median...
System science offers a unique set of tools, including causal loop diagrams (CLDs), for stakeholders to better grasp the complexity factors surrounding quality life. Because health-related life (HRQoL) cancer immunotherapy patients exists within an intricate system affected by and affecting many across multiple dimensions, development systems-level model can provide powerful framework aid understanding this complexity. We developed CLD HRQoL patients.We first applied literature-based...
Aims To evaluate changes in QT duration during low-dose haloperidol use, and determine associations between clinical variables potentially dangerous prolongation. Methods In a retrospective cohort study tertiary university teaching hospital The Netherlands, all 1788 patients receiving 2005 2007 were studied; ninety-seven suitable for final analysis. Rate-corrected (QTc) was measured before, after use. Clinical before use at the time of each ECG recording retrieved from charts. Mixed model...
Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) can hamper the clinical benefit of CAR T-cell therapy in patients with relapsed/refractory large B-cell lymphoma (r/r LBCL). To assess risk CRS ICANS, endothelial activation stress index (EASIX), modified EASIX (m-EASIX), simplified (s-EASIX), CRP/ferritin (EASIX-F(C)) were proposed. This study validates these scores a consecutive population-based cohort. Patients r/r LBCL treated axicabtagene...
Ventricular fibrillation in patients with Brugada syndrome (BrS) is often initiated by premature ventricular contractions (PVCs). Presence of SCN5A mutation increases the risk PVCs upon exposure to sodium channel blockers (SCB) baseline type-1 ECG. In without ECG, however, effect on SCB-induced arrhythmia unknown. We aimed establish whether presence/absence, type, and topology correlates PVC occurrence during ajmaline infusion.We investigated 416 ECG who underwent testing analysis. A was...
Immunotherapies, such as immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy, have significantly improved the clinical outcomes of various malignancies. However, they also cause immune-related adverse events (irAEs) that can be challenging to predict, prevent treat. Although likely interact with health-related quality life (HRQoL), most existing evidence on this topic has come from trials eligibility criteria may not accurately reflect real-world settings. The QUALITOP...
Background: People with epilepsy are at increased risk for sudden death.The most prevalent cause of death in the general population is cardiac arrest (SCA) due to ventricular fibrillation (VF).SCA may contribute incidence people epilepsy.We assessed whether SCA by determining among active a community-based study. Methods and Results:This investigation was part Amsterdam Resuscitation Studies (ARREST) Netherlands.It designed assess population.All cases study area were identified matched...
Prophylaxis strategies for Graft versus host disease (GVHD) in allogeneic hematopoietic cell transplantation (allo-HCT) frequently encompass a combination of calcineurin inhibitor (CNI) with either methotrexate (MTX) or mycophenolate mofetil (MMF). The aim this retrospective, EBMT registry-based study was to determine outcome differences chronic myeloid malignancies and secondary acute leukemia (sAML) between MTX- MMF-based prophylaxis regimens while taking potential heterogeneity subgroups...