A5067390651- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Education, Psychology, and Social Research
- Neutropenia and Cancer Infections
- Multiple Myeloma Research and Treatments
- Myasthenia Gravis and Thymoma
- Hematological disorders and diagnostics
- COVID-19 and healthcare impacts
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lung Cancer Research Studies
- CNS Lymphoma Diagnosis and Treatment
- Blood disorders and treatments
- Antifungal resistance and susceptibility
- Pharmaceutical studies and practices
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Organ and Tissue Transplantation Research
- Long-Term Effects of COVID-19
- Transactional Analysis in Psychotherapy
Masaryk University
2010-2025
University Hospital Brno
2010-2024
Ocní klinika
2010-2019
COVID-19 is posing a significant threat to health in vulnerable patients, such as immunocompromised patients.For hematopoietic cell transplantation (HCT) recipients and patients with hematologic malignancies it known that leads severe morbidity high mortality compared the general population [1][2][3].For treated Chimeric Antigen Receptor T-cell (CAR-T-cell) therapy for B-cell however, descriptions of clinical course outcome are still limited small case series reports...
Introduction COVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients. Methods This study reports on 986 patients reported to the EBMT registry during first 29 months of pandemic. Results The median age was 50.3 years (min – max; 1.0 80.7). time from most recent HCT diagnosis 20 0.0 383.9). 19.3 (0.0 - 287.6) 2020, 21.2 (0.1 324.5) 2021, 19.7 383.9) 2022 (p = NS). 145/986 (14.7%) died; 124 (12.6%) due 21 other...
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Abstract COVID-19 has been associated with high mortality in patients treated Chimeric Antigen Receptor (CAR) T-cell therapy for hematologic malignancies. Here, we investigated whether the outcome improved over time primary objective of assessing COVID-19-attributable Omicron period 2022 compared to previous years. Data this multicenter study were collected using MED-A and report forms developed by EBMT. One-hundred-eighty included analysis, 39 diagnosed 2020, 35 2021 106 2022. The median...
To evaluate the prognostic power of minimal residual disease (MRD) monitored by polymerase chain reaction at defined time points during early treatment in adult patients with acute lymphoblastic leukemia (ALL).Seventy-one were treated according to GMALL 07/2003 protocol and evaluated for MRD bone marrow specific clonal rearrangements Ig/TCR BCR-ABL negative ALL or fusion gene transcript positive ALL.Three-year overall survival (OS) was 94% reaching complete molecular response (CMR) after...
While achieving prolonged remissions in other B cell-derived malignancies, chimeric antigen receptor (CAR) T cells still underperform when injected into patients with chronic lymphocytic leukemia (CLL). We studied the influence of genetics on CLL response to anti-CD19 CAR T-cell therapy. First, we 32 primary samples composed 26 immunoglobulin heavy-chain gene variable (IGHV)-unmutated (9 ATM-mutated, 8 TP53-mutated, and 9 without mutations ATM, TP53, NOTCH1 or SF3B1) 6 IGHV-mutated...
Xenograft models represent a promising tool to study the pathogenesis of hematological malignancies. To establish reliable and appropriate in vivo model aggressive human B-cell leukemia lymphoma we xenotransplanted four p53-mutated cell lines one ATM-mutated line into immunodeficient NOD/SCID IL2Rγ-null mice. The MEC-1, SU-DHL-4, JEKO-1, REC-1, GRANTA-519 were transplanted intraperitoneally or subcutaneously engraftment was investigated using immunohistochemistry flow cytometry. We found...
Mobilization of peripheral blood stem cells (PBSC) using the granulocyte colony-stimulating factor (G-CSF) has enabled collection even from older donors and those with comorbidities. Several clinical parameters have been reported to predict success PBSC mobilization. The aim our study was evaluate safety donation in a cohort 167 sibling after mobilization G-CSF 16 μg/kg/day for 5 days during short- long term follow-up analyse efficacy, toxicity factors influencing CD34+ capacity. All...
There is only limited data on cytomegalovirus (CMV) prophylaxis with high-dose (HD) aciclovir after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We performed a retrospective analysis total of 179 patients who underwent their allo-HSCT HD-aciclovir at our center. A clinically significant CMV infection (cs-CMVi) was observed in 56 (31%) cases median time 49 (range 25-147) days HSCT. significantly higher rate seropositive recipients seronegative donor (74%) compared to donor,...
Introduction BCR-ABL1-like acute lymphoblastic leukemia (ALL) is a high-risk disease with complex genomic background. Though extensively studied, data on the frequency and mutual associations of present mutations are still incomplete in adult patients. This retrospective study aims to map landscape B-other ALL cohort patients focus subtype.Methods We analyzed bone marrow peripheral blood samples treated consecutively at three major Czech teaching hospitals. Samples were by cytogenetic...
Muž ve věku 60 let byl vyšetřován pro intenzivní zánětlivou reakci, noční pocení, subfebrilie, později febrilie a úbytek hmotnosti 18 kg za 7 měsíců. Hodnota CRP byla 270 mg/l, tedy vyšší než 20násobek horního limitu fyziologického rozmezí. Byla přítomna reaktivní leukocytóza (10 × 109/l), trombocytóza (530 zvýšená koncentrace fibrinogenu (> g/l) anémie s hemoglobinem 80 g/l. Žádná infekce ani systémové autoimunitní onemocnění nebylo prokázáno. Pacient měl normální funkce ledvin neměl žádná...
Germline mutations in ETV6 gene cause inherited thrombocytopenia with leukemia predisposition. Here, we report on functional validation of W380R mutation segregating a family where two members also suffered from acute lymphoblastic (ALL) or essential thrombocythemia (ET). In-silico analysis predicted impaired DNA binding due to mutation. Functional showed that this prevents the protein localizing into cell nucleus and impairs transcriptional repression activity ETV6. Based germline mutation,...
Abstract Near‐haploid acute lymphoblastic leukemia is rare subgroup of the disease, which very important due to poor prognosis and resistance treatment including novel monoclonal antibodies CAR‐T therapy.
Abstract Aim The aim of this study was to analyse the outcomes patients with large B‐cell lymphoma (LBCL) treated chimeric antigen receptor T‐cell therapy (CAR‐Tx), a focus on after CAR failure, and define risk factors for rapid progression further treatment. Methods We analysed 107 LBCL from Czech Republic Slovakia who were in ≥3rd‐line tisagenlecleucel or axicabtagene ciloleucel between 2019 2022. Results overall response rate (ORR) 60%, 50% complete (CR) rate. median progression‐free...