A5045322247- Hematopoietic Stem Cell Transplantation
- Women's cancer prevention and management
- Acute Myeloid Leukemia Research
- Testicular diseases and treatments
- Liver physiology and pathology
- Palliative and Oncologic Care
- Neuroblastoma Research and Treatments
- Biomedical Text Mining and Ontologies
- Semantic Web and Ontologies
- Radiomics and Machine Learning in Medical Imaging
- Platelet Disorders and Treatments
- CAR-T cell therapy research
- Lung Cancer Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Data Quality and Management
- T-cell and B-cell Immunology
- Neutropenia and Cancer Infections
- T-cell and Retrovirus Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Long-Term Effects of COVID-19
- Drug-Induced Ocular Toxicity
- Brain Metastases and Treatment
- Pharmacy and Medical Practices
IPO Porto
1994-2024
Brazilian Society of Computational and Applied Mathematics
2024
Pitié-Salpêtrière Hospital
2023
Sorbonne Université
2023
Instituto Português de Oncologia de Coimbra Francisco Gentil
2004-2019
The Netherlands Cancer Institute
1998-1999
Vrije Universiteit Amsterdam
1998
Oncode Institute
1998
Hematopoietic stem cell transplantation (HSCT) represents a curative treatment for patients with severe combined immunodeficiency (SCID), group of monogenic immune disorders an otherwise fatal outcome.We performed comprehensive multicenter analysis genotype-specific HSCT outcome, including detailed reconstitution (IR) and the predictive value clinical outcome.HSCT outcome was studied in 338 genetically confirmed SCID who underwent 2006-2014 were registered SCETIDE registry. In representative...
Optimizing natural killer (NK) cell alloreactivity could further improve outcome after allogeneic hematopoietic transplantation (alloHCT). The donor’s Killer-cell Immunoglobulin-like Receptor (KIR) genotype may provide important information in this regard. In the past decade, different models have been proposed aiming at maximizing NK activation by activating KIR-ligand interactions or minimizing inhibitory interactions. Alternative classifications intended predicting alloHCT donor...
Introduction COVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients. Methods This study reports on 986 patients reported to the EBMT registry during first 29 months of pandemic. Results The median age was 50.3 years (min – max; 1.0 80.7). time from most recent HCT diagnosis 20 0.0 383.9). 19.3 (0.0 - 287.6) 2020, 21.2 (0.1 324.5) 2021, 19.7 383.9) 2022 (p = NS). 145/986 (14.7%) died; 124 (12.6%) due 21 other...
Several recent studies have shown the promising efficacy of chimeric antigenic receptor (CAR) T cells in treating CNS lymphomas. However, data on neurotoxicity this setting are limited. The objective study was to describe patients with lymphoma treated anti-CD19 CAR and identify risk factors. We retrospectively selected adult isolated relapse B-cell lymphomas at Pitié-Salpêtrière Hospital between January 2020 2024 from French Oculo-Cerebral Lymphoma network database. collected clinical,...
This paper presents OntoDrug, an ontology designed to enhance medicine management in Brazil by integrating regulatory frameworks and standardizing terminologies. OntoDrug improves patient safety treatment efficacy accurately identifying classifying medications supporting interoperability with health information systems. A proof-of-concept application integrated into the Hospital das Clínicas de Marília’s hospital EHR system demonstrated OntoDrug’s utility, achieving high precision recall. An...
A sífilis congênita é uma patologia transmitida da mãe para o filho ainda na gestação, transmissão vertical. Objetivo foi em analisar casos de gestantes infectadas com no período janeiro 2020 e dezembro 2023. metodologia utilizada análise documental, por meio qual, foram coletados dados dos prontuários atendidas nas Unidades Básicas Saúde (UBS) Frei Silvestre Maura Ferreira, município Pimenta Bueno-RO. Para os resultados discussões, analisados 27 notificados duas UBS, relação a escolaridade...
The MET protooncogene, c-MET, encodes a cell surface tyrosine kinase receptor. ligand for c-MET is hepatocyte growth factor (HGF), also known as scatter (SF), which to affect proliferation and motility of primarily epithelial cells. Recently, HGF/SF was shown haemopoiesis. Studies with transfected NIH3T3 cells indicated that the HGF/SF-c-MET interaction promotes invasion in vitro vivo. We previously demonstrated induces adhesion c-MET-positive B-lymphoma extracellular matrix molecules,...
Introduction: The Urgeiriça mines were once the main uranium producer in Portugal. aim of this study was to estimate benefit low-dose chest computed tomography (LDCT) for lung cancer screening former miners that considered as being at high-risk.Methods: A subgroup Uranium National Company exposed and with a smoking load greater than 20 pack-years, agreed perform LDCT. Fleischner Society Guidelines used classify nodules establish follow-up.Results: Initially, 265 employees included. mean time...
Abstract BACKGROUND CAR-T cell therapy represents one of the major progress last years in aggressive B-cell lymphomas. Its use central nervous system (CNS) lymphomas has been limited due to fear neurotoxicity but several recent studies have showed promising efficacy this setting. The aim study was focus on neurotoxicy CNS lymphoma patients treated with cells. MATERIAL AND METHODS Patients isolated relapse DLBCL commercial cells at Pitié-Salpêtrière hospital were retrospectively selected. We...
Peripheral T-cell lymphomas (PTCLs) are a rare and heterogeneous group of aggressive comprising more than 20 diff erent entities representing about 10% all non-Hodgkin diagnosed in the Western World.Given their heterogeneity, there is no consensus regarding best fi rst-line treatment role autologous/allogeneic hematopoietic stem cell transplantation (HSCT) as consolidation controversial.To examine real-world outcomes for patients with PTCL submitted to HSCT our institution we retrospectively...
AIMS: To study the expression of human T lymphotropic virus (HTLV) Tax gene in peripheral blood mononuclear cells. METHODS: Blood was collected from 72 patients with lymphoproliferative disorders. Serum all assayed for antibodies directed against HTLV-I structural proteins by ELISA and western blotting. RNA purified fresh cells amplified reverse transcription polymerase chain reaction (RT-PCR). After Southern blotting, PCR products were hybridised a 32P end-labelled probe specific gene....
Introduction: CAR-T cell therapy represents one of the major progress last years in aggressive B-cell lymphomas. Its use central nervous system (CNS) lymphomas has been limited due to fear neurotoxicity but several recent studies have showed promising efficacy this setting. The aim study was focus on CNS lymphoma patients treated with cells. Methods: Patients isolated relapse DLBCL commercial cells at Pitié-Salpêtrière hospital were retrospectively selected. We considered only neurological...