A5071364391- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Mesenchymal stem cell research
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- Tissue Engineering and Regenerative Medicine
- Platelet Disorders and Treatments
- Bone Tissue Engineering Materials
- Corneal Surgery and Treatments
- Periodontal Regeneration and Treatments
- Pluripotent Stem Cells Research
- Chronic Myeloid Leukemia Treatments
- Amyotrophic Lateral Sclerosis Research
- Peptidase Inhibition and Analysis
- Wound Healing and Treatments
- Cancer Treatment and Pharmacology
- Acute Lymphoblastic Leukemia research
- CNS Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Endodontics and Root Canal Treatments
- Neurogenetic and Muscular Disorders Research
Hospital Universitario Virgen de la Arrixaca
2015-2024
Universidad de Murcia
2015-2024
Instituto Murciano de Investigación Biosanitaria
2015-2024
Universidad de Navarra
2024
Universitat de Barcelona
2024
Hospital Clínic de Barcelona
2024
Clinica Universidad de Navarra
2024
Centro de Investigación Biomédica en Red de Cáncer
2024
Hospital General Universitario Morales Meseguer
2002-2023
Instituto de Salud Carlos III
2018-2021
Assessing measurable residual disease (MRD) has become standard with many tumors, but the clinical meaning of MRD in multiple myeloma (MM) remains uncertain, particularly when assessed by next-generation flow (NGF) cytometry. Thus, we aimed to determine applicability and sensitivity MRD-negative criterion defined International Myeloma Working Group (IMWG).In PETHEMA/GEM2012MENOS65 trial, 458 patients newly diagnosed MM had longitudinal assessment after six induction cycles bortezomib,...
In Brief Background Degenerative disc disease often causes severe low-back pain, a public health problem with huge economic and life quality impact. Chronic cases require surgery, which may lead to biomechanical problems accelerated degeneration of the adjacent segments. Autologous mesenchymal stromal cells (MSC) treatments have shown feasibility, safety strong indications clinical efficacy. We present here randomized, controlled trial using allogeneic MSC, are logistically more convenient...
PURPOSE: To analyze clinical outcome and significant prognostic factors for overall (OS) time to treatment failure (TTF) in a group of 494 patients with Hodgkin’s disease (HD) undergoing autologous stem-cell transplantation (ASCT). PATIENTS AND METHODS: Detailed records from the Grupo Español de Linfomas/Transplante Autólogo Médula Ósea Spanish Cooperative Group Database on HD who received an ASCT between January 1984 May 1998 were reviewed. Two hundred ninety-eight males 196 females median...
Reduced-intensity conditioning (RIC) for allogeneic stem-cell transplantation (allo-SCT) reduces nonrelapse mortality (NRM). This reduction makes it possible patients who are ineligible high-dose myeloablative allo-SCT to benefit from graft-versus-leukemia reaction. In this multicenter, prospective study of with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS), we investigated the efficacy RIC a human leukocyte antigen-identical sibling by using regimen that uses...
Abstract The objective of this article is to assess the safety intraspinal infusion autologous bone marrow mononuclear cells (BMNCs) and, ultimately, look for histopathological signs cellular neurotrophism in amyotrophic lateral sclerosis (ALS) patients. We conducted an open single arm phase I trial. After 6 months observation, BMNCs were infused into posterior spinal cord funiculus. Safety was primary endpoint and defined as absence serious transplant-related adverse events. In addition,...
To investigate in vitro the cytocompatibility of calcium silicate-containing endodontic sealers MTA Fillapex and TotalFill BC Sealer on human periodontal ligament stem cells (hPDLSCs) by assaying their biological responses compare them with that observed when using an epoxy resin-based sealer (AH Plus).Specimens from three different were eluated culture medium for 24 h. The cytotoxicity these eluates was evaluated MTT assay. In addition, scratch wound healing model used to determine effects...
Abstract Aims To investigate the cytotoxicity and bioactivity of several pulpotomy materials: Biodentine (Septodont, Saint‐Maur‐des‐Fosses, France) MTA (Angelus, Londrina, PR , Brazil), Theracal LC (Bisco Inc., Schamburg, IL USA ) IRM (Dentsply DeTrey GmbH, Konstanz, Germany), after contact with stem cells isolated from human exfoliated primary teeth ( SHED s). Methodology s were cultured in presence eluates various materials for 24, 48 72 h. Cell viability was determined by mitochondrial...
Abstract Aim To evaluate the biological effects in vitro of MTA‐Angelus (MTA‐Ang; Angelus, Londrina, PR, Brazil), MTA Repair HP (MTA‐HP; Angelus) and NeoMTA Plus (NeoMTA‐P; Avalon Biomed Inc, Bradenton, FL, USA) on human dental pulp stem cells ( h DPSCs). Methodology Cell viability cell migration assays were performed using eluates each material. morphology attachment to different materials, hDPSCs directly seeded onto material surfaces analysed by immunocytofluorescence scanning electron...
Significance Glioblastoma (GB) is the most lethal brain malignancy without an effective treatment. In this study, we demonstrate that tumor-induced change in chaperone-mediated autophagy (CMA) host perivascular cells a targetable process to prevent GB progression. CMA regulates pericyte interaction with tumor and sustains acquired immunosuppressive function of pericytes, which required for survival. Blockage results changes protein levels involved cell-to-cell affects secretory phenotype,...
Hematopoietic stem cell transplantation (HSCT) represents a curative treatment for patients with severe combined immunodeficiency (SCID), group of monogenic immune disorders an otherwise fatal outcome.We performed comprehensive multicenter analysis genotype-specific HSCT outcome, including detailed reconstitution (IR) and the predictive value clinical outcome.HSCT outcome was studied in 338 genetically confirmed SCID who underwent 2006-2014 were registered SCETIDE registry. In representative...
The coronavirus disease 2019 (COVID-19) pandemic, a viral illness caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2),1 has produced at time of this writing nearly 33 million cases infection, with over deaths in 235 countries,2 causing an unprecedented burden on healthcare systems and global socioeconomic crisis. As pandemic spreads, knowledge course, as well potential risk factors predictors severity is increasing daily, initial data from randomised controlled studies...