A5021238912- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Fungal Infections and Studies
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Cutaneous lymphoproliferative disorders research
- CNS Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myeloid Leukemia Research
- Polyomavirus and related diseases
- Vascular Tumors and Angiosarcomas
- Transplantation: Methods and Outcomes
- Platelet Disorders and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Chronic Myeloid Leukemia Treatments
- Cancer Treatment and Pharmacology
- Venous Thromboembolism Diagnosis and Management
- Hemophilia Treatment and Research
- Virus-based gene therapy research
Hospital de Cruces
2015-2025
BioCruces Health research Institute
2015-2025
University of the Basque Country
1997-2025
University of California Davis Medical Center
2006-2024
University of Seychelles
2024
Parc de Salut
2024
Hospital Universitario Ramón y Cajal
2016-2023
Universidad El Bosque
2023
Osakidetza
2021-2023
Instituto de Investigación Marqués de Valdecilla
2023
Background. Mammography has led to earlier detection of subclinical ductal carcinoma in situ (DCIS) the breast either as nonpalpable calcifications or an incidental finding a biopsy performed for another reason. Many women whom DCIS was detected early may not be destined have invasive carcinoma. How should treated if that is case? What role excision and surveillance only alternative mastectomy irradiation?. Methods. All patients with non-palpable were eligible this study. Diagnosis...
A small percentage of human immunodeficiency virus (HIV)-infected individuals, termed elite controllers, are able to spontaneously control HIV replication in blood. As the gastrointestinal mucosa is an important site transmission and as well CD4+ T-cell depletion, it understand nature immune responses occurring this compartment. Although role HIV-specific CD8+ mucosal tissues has been described, few studies have investigated T cells. In study, we assessed rectal 28 "controllers" (viral load...
ABSTRACT Gut-associated lymphoid tissue (GALT) is a major site of HIV replication and CD4 + T cell depletion. Furthermore, microbial translocation facilitated by mucosal damage likely contributes to the generalized immune activation observed in infection. Regulatory cells (Treg) help maintain homeostasis suppress harmful during infection; however, case persistent viral infections such as HIV, their role less clear. Although number studies have examined Treg blood chronic infection, few...
The breakdown of vascular integrity triggers a series reactions, initially involving vasoconstriction phenomenon that reduces blood loss and leads to platelet plug formation under changing flow conditions. Once the has formed, coagulation system is activated in order allow fibrin, which anchors vessel breach. Finally, once damage resolved, fibrin eliminated through fibrinolysis. This article explains all these regulatory mechanisms.
Goals To compare the long-term outcome of medical, percutaneous, and surgical treatment abdominal pelvic abscesses complicating Crohn's disease. Study All patients with disease an abscess treated at one institution during a 10-year period were retrospectively identified. We reviewed hospital outpatient records contacted for telephone interviews. Outcome measures included recurrence, subsequent surgery disease, medications used time most recent follow-up. Results Fifty-one subjects...
We have retrospectively analysed 344 multiple myeloma (MM) patients (202 de novo patients) treated in a non‐uniform way whom high‐dose therapy and autologous stem cell transplantation (ASCT) response was simultaneously measured by both electrophoresis (EP) immunofixation (IF). Patients complete remission (CR) EP were further subclassified as CR1 when IF negative CR2 it remained positive. Partial responders (PR) also PR1 (very good PR, > 90% reduction M‐component) or PR2 (50–90%...
Previous studies have suggested that polyfunctional mucosal CD8(+) T-cell responses may be a correlate of protection in HIV controllers. Mucosal breadth and/or specificity also contribute to defining protective responses. In this study, rectal Gag, Env, and Nef were mapped at the peptide level four subject groups: elite controllers (n = 16; viral load [VL], <75 copies/ml), viremic 14; VL, 75 2,000 noncontrollers >10,000 antiretroviral-drug-treated subjects 8; copies/ml). all groups,...
ABSTRACT Introduction Intron 22 inversion mutation of F8 (inv22) is the most frequent cause Haemophilia A (HA) and present in approximately 45% severe HA cases. This disrupts gene continuity, leading to a truncated protein. Traditional methods for detecting inv22, including inverse‐shifting PCR long‐range PCR, are accurate but labour‐intensive. inv22 mRNA transcript contains short (51 base pairs) abnormal exon 23. Thus, reverse‐transcription has been proposed diagnosis patients with HA. Aim...
The intestinal mucosa displays robust virus replication and pronounced CD4+ T-cell loss during acute human immunodeficiency type 1 (HIV-1) infection. ability of HIV-specific CD8+ T-cells to modulate disease course has prompted intensive study, yet the significance virus-specific in mucosal sites remains unclear.We evaluated five distinct effector functions HIVgag-specific rectal blood, individually combination, relationship clinical status antiretroviral therapy (ART). In subjects not on...
Summary Introduction Congenital haemolytic anaemia ( CHA ) refers to a group of genetically heterogeneous disorders, mainly caused by changes in genes encoding globin chains, cytoskeletal proteins and red cell enzymes, which accurate diagnosis can be challenging with conventional techniques. Methods To set‐up comprehensive assay for detecting mutations that could improve aetiological diagnosis, we designed custom panel sequencing coding regions from 40 known involved the pathogenesis , using...
High‐dose chemoradiotherapy conditioning regimens for autologous stem cell transplantation (ASCT) are generally held to give similar results in multiple myeloma (MM), but no specific comparative study has been published. We addressed this issue by comparing the main high‐dose used Spanish Registry. Patient cohorts included 315 cases treated with 200 mg/m 2 melphalan (MEL200), 127 patients 140 plus total body irradiation (MEL140 + TBI) and 121 12 mg/kg busulphan (BUMEL). After ASCT,...
Abstract Objectives: Angioimmunoblastic T‐cell lymphoma (AIL) is a rare with poor prognosis and no standard treatment. Here, we report our experiences 19 patients treated high‐dose chemotherapy autologous stem cell transplantation (HDC/ASCT) within the GELTAMO co‐operative group between 1992 2004. Methods: The median age at was 46 yr. Fifteen underwent procedure as front‐line therapy four salvage therapy. Most received peripheral cells (90%) coupled BEAM or BEAC conditioning regimen (79%)....