A5027470927- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Viral-associated cancers and disorders
- Galectins and Cancer Biology
- Animal Disease Management and Epidemiology
- Immunotherapy and Immune Responses
- Rheumatoid Arthritis Research and Therapies
- Immune Cell Function and Interaction
- Colorectal Cancer Surgical Treatments
- Celiac Disease Research and Management
- CNS Lymphoma Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Vector-Borne Animal Diseases
- Anorectal Disease Treatments and Outcomes
- Workaholism, burnout, and well-being
- Cytokine Signaling Pathways and Interactions
- Helicobacter pylori-related gastroenterology studies
- Mediterranean and Iberian flora and fauna
- Stoma care and complications
- Spondyloarthritis Studies and Treatments
National University of General San Martín
2017-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2023
National University of Tres de Febrero
2023
Hospital Regional Universitario de Málaga
2022
Hospital General de Granollers
2019-2020
Hospital Doctor José Molina Orosa
2003-2017
Acerinox (Spain)
2007-2009
Consejo Superior de Investigaciones Científicas
2000-2003
Instituto de Parasitología y Biomedicina "López - Neyra"
2001-2002
Leiden University
2002
PURPOSE: The feasibility and safety of stem cell-based therapy with expanded adipose-derived cells (ASCs) has been investigated in a phase I clinical trial. present study was designed as II multicenter, randomized controlled trial to further investigate the effectiveness ASCs treatment complex perianal fistulas. METHODS: Patients fistulas (cryptoglandular origin, n = 35; associated Crohn's disease, 14) were randomly assigned intralesional fibrin glue or plus 20 million ASCs. Fistula healing...
To investigate a possible association of Fcgamma receptor IIIA (FcgammaRIIIA) gene polymorphism at position 158 with susceptibility to, and the outcome of, rheumatoid arthritis (RA).One hundred seventeen RA patients 142 unrelated healthy control subjects from same geographic area were studied. Genotyping for FcgammaRIIIA-158V/F was performed by method based on polymerase chain reaction (PCR) restriction fragment length analysis using amplification-created sites. HLA-DRB1 typing...
Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments. Upfront consolidation autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigated in randomized trials. We designed multicenter, international, retrospective study the main objective comparing progression-free survival and overall patients PTCL who underwent ASCT complete...
Abstract Objective To investigate the association of poly(ADP‐ribose) polymerase 1 (PARP‐1) gene promoter polymorphism with rheumatoid arthritis (RA) predisposition. Methods An study 213 Spanish RA patients and 242 healthy subjects was carried out to all known PARP‐1 polymorphisms, i.e., a CA microsatellite repeat, poly(A) n , 3 single point mutations (C410T, C1362T, G1672A), disease susceptibility. Additionally, we analyzed distribution polymorphisms in 58 families or more affected members....
To evaluate the contributions of HLA-DQ and -DR polymorphisms to susceptibility rheumatoid arthritis (RA) in a population southern Spain, compare value shared epitope (SE) RA protection (RAP) models accounting for HLA class II region's contribution predisposition.One hundred sixty patients 153 healthy controls were typed HLA-DRB1 -DQB1 using high-resolution DNA techniques. Distributions predisposing DRB1 alleles control subjects according SE model compared with distributions DQ protective...
Abstract: Major histocompatibility complex class I chain‐related genes (MIC) belong to a multicopy gene family located within the HLA region of chromosome 6. They encode for proteins that have completely different organization, expression, and products from classical products. One member this is MICA gene, which characterized by its high degree polymorphism, with over 50 alleles described. Moreover, exon 5 presents microsatellite polymorphism consisting variable number GCT repeats 4, 5, 6,...
The aim of this study was to analyze the role major histocompatibility complex class I chain-related gene A (MICA) transmembrane polymorphism in celiac disease (CD) susceptibility.Sixty-one Spanish families were genotyped for MICA by a polymerase chain reaction method combined with fluorescent technology. transmission disequilibrium test performed investigate preferential alleles affected offspring.The A5.1 allele shown be significantly transmitted siblings. This association independent...
Our aim was to examine, using microsatellite (ms) markers, the contribution of telomeric part HLA region rheumatoid arthritis (RA) predisposition in Spanish population. We have looked at distribution DQB1, DRBI and five ms loci (D6S1014, D6S273, D6STNFa, MIB C1-2-5) within 147 RA patients 202 control subjects. A total 19 conserved configurations were observed, twelve them linkage disequilibrium with particular DQB1-DRB1 haplotypes. Interestingly, haplotype c1...
Summary The use of highly effective rituximab‐containing therapy for treating diffuse large B‐cell lymphoma ( DLBCL ) makes it more difficult to salvage relapsed or refractory patients. Autologous stem‐cell transplantation ASCT is the reference treatment these patients, but impact previous exposure rituximab on subsequent results remains unknown. We analysed 248 patients with grade 3B follicular pre‐treated as part first‐line (R+ group) who received , in comparison a control group 127...
Methods: We studied all patients starting dialysis therapy between 1 January 1995 and 31 December 2009 in our center. The following variables at initiation end-stage renal disease (ESRD) were analysed: estimated glomerular filtration rate (eGFR), age, gender, diabetes mellitus, serum albumin, hemoglobin, period of initiation, history ischemic heart stroke. Multivariate Cox model was used to calculate adjusted patient survival.
Objective To evaluate the contributions of HLA–DQ and –DR polymorphisms to susceptibility rheumatoid arthritis (RA) in a population southern Spain, compare value shared epitope (SE) RA protection (RAP) models accounting for HLA class II region's contribution predisposition. Methods One hundred sixty patients 153 healthy controls were typed HLA–DRB1 –DQB1 using high-resolution DNA techniques. Distributions predisposing DRB1 alleles control subjects according SE model compared with...
Pestivirus envelope protein E2 is crucial to virus infection and accomplishes virus-receptor interaction during entry. However, mapping of residues mediating these interactions has remained unexplored. In this study, investigate the structure-function relationship for a β-hairpin motif exposed solvent in crystal structure bovine viral diarrhea (BVDV) E2, we designed two amino acidic substitutions that result change electrostatic potential. First, using wild type mutant expressed as soluble...