A5010636830- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Dental materials and restorations
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Periodontal Regeneration and Treatments
- Graphene and Nanomaterials Applications
- Endodontics and Root Canal Treatments
- Patient Satisfaction in Healthcare
- Calcium Carbonate Crystallization and Inhibition
- Advanced X-ray and CT Imaging
- Musculoskeletal pain and rehabilitation
- biodegradable polymer synthesis and properties
- Spine and Intervertebral Disc Pathology
- RNA Interference and Gene Delivery
- Invertebrate Immune Response Mechanisms
- Head and Neck Anomalies
- Reliability and Agreement in Measurement
- Circadian rhythm and melatonin
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
Universidad Católica San Antonio de Murcia
2015-2024
Tissue Regeneration Systems (United States)
2023
Universidad de Murcia
2007-2019
Instituto Murciano de Investigación Biosanitaria
2018
Hospital Universitario Virgen de la Arrixaca
2006-2017
Universidad de Granada
2012
Hospital Regional Universitario de Málaga
2006
Imperial College London
2002
Abstract Scaffolds made of polycaprolactone and nanocrystalline silicon‐substituted hydroxyapatite have been fabricated by 3D printing rapid prototyping technique. To asses that the scaffolds fulfill requirements to be considered for bone grafting applications, they were implanted in New Zealand rabbits. Histological radiological studies demonstrated exhibited an excellent osteointegration without interposition fibrous tissue between implants immune response after 4 months implantation. In...
Abstract Biomaterial pieces, with suitable osteogenic properties for use in the treatment of bone defects and capability to avoid infections, have been synthesized. These materials are composed exclusively gentamicin sulfate bioactive SiO 2 ‐CaO‐P O 5 sol–gel glass (previously synthesized). Implant processing was achieved by uniaxial isostatic pressure components mixture. After implanting pieces into rabbit femur, we studied (i) antibiotic release, determining concentration proximal distal...
Biomaterial pieces with osteogenic properties, suitable for use in the treatment of bone defects, were synthesized. The materials, which avoid infections, are exclusively composed gentamicin sulfate and bioactive SiO2-CaO-P2O5 sol-gel glass (synthesized previously), manufactured by means uniaxial isostatic pressure mixed components. After implanting into rabbit femur, we studied (1) antibiotic release, determining concentration proximal distal bone, liver, kidney, lung as a function time,...
Abstract This study reports on the in vitro and vivo behavior of α‐tricalcium phosphate (αTCP) also αTCP doped with either 1.5 or 3.0 wt % dicalcium silicate (C 2 S). The ceramics were successfully prepared by powder metallurgy method combined homogenization heat treatment procedures. All materials composed a single‐phase, case pure material, solid solution C S for αTCP, which stable at room temperature. tested bioactivity simulated body fluid, cell culture medium containing adult...
This aim of this research was to develop a novel ceramic scaffold evaluate the response bone after implantation in New Zealand (NZ) rabbits. Ceramics were prepared by polymer replication method and inserted into NZ Macroporous scaffolds with interconnected round-shaped pores (0.5–1.5 mm = prepared). The acted as physical support where cells osteoblastic capability found migrate, processes, newly immature mature tissue colonized on surface (initially) material’s interior. new induced about...
Acute and chronic bone infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA), remains a major complication therapeutic challenge. It is documented that local administration of vancomycin offers better results than the usual routes (e.g., intravenous) when ischemic areas are present. In this work, we evaluate antimicrobial efficacy against S. epidermidis novel hybrid 3D-printed scaffold based on polycaprolactone (PCL) chitosan (CS) hydrogel loaded with...
Abstract Hydroxyapatite (HA) is widely applied as bone graft material due to its osteoconductive potential and well‐established biocompatibility. In this work, macroporous hydroxyapatite structures made through foaming of aqueous suspensions gelcasting were tested for in vivo osteointegration. These foams are composed a three‐dimensional array spherical pores with diameters approximately 100–500 μm, interconnected by windows smaller size the range 30–120 μm. The HA implanted tibia albino New...
Abstract Purpose: To carry out a radiological and histomorphometric evaluation of bone response to two xenografts animal origin, one porcine, the other bovine, inserted in rabbits' tibiae. Material methods: Twenty New Zealand rabbits weighing 3900–4500 g were used. bovine grafts (Endobon ® ) granulated form 500–1000 μm granulometry proximal metaphyseal area animals' right tibia, 20 porcine (OsteoBiol mp3) 600–1000 left tibia. Following graft insertion, animals sacrificed four groups five,...
Abstract Tendon and ligament tissue engineering require scaffolds for the treatment of various conditions in medical field. These must meet requirements such as high tensile strength, biocompatibility, fast stable repair a rate degradation that allows damaged tissue. In this work, we propose use silkworm gut fiber braids materials to temporarily replace type tissues. The mechanical characterization made with different number silk fibers is provided, well descriptive analysis proliferation...