A5101442926- Advanced Harmonic Analysis Research
- Mathematical Analysis and Transform Methods
- Radiopharmaceutical Chemistry and Applications
- Stochastic processes and financial applications
- Medical Imaging Techniques and Applications
- Horticultural and Viticultural Research
- Advanced Banach Space Theory
- Antibiotic Resistance in Bacteria
- Advanced Mathematical Modeling in Engineering
- Radioactive Decay and Measurement Techniques
- Infections and bacterial resistance
- Silk-based biomaterials and applications
- Heart Failure Treatment and Management
- Pharmaceutical and Antibiotic Environmental Impacts
- Smoking Behavior and Cessation
- Melanoma and MAPK Pathways
- Infection Control and Ventilation
- Differential Equations and Boundary Problems
- Cancer Mechanisms and Therapy
- Cell Adhesion Molecules Research
- Neutropenia and Cancer Infections
- Nonlinear Partial Differential Equations
- Forest Insect Ecology and Management
- Effects of Radiation Exposure
- Electrospun Nanofibers in Biomedical Applications
Hospital Universitario Virgen de la Arrixaca
2004-2024
Universidad de Murcia
2024
University of California, Riverside
2022-2023
Instituto Murciano de Investigación Biosanitaria
2022-2023
Instituto Nacional de Cancerología
2012-2018
Stony Brook University
2018
Santa Lucía University General Hospital
2012-2017
University of Puerto Rico, Medical Sciences Campus
2012-2016
Christie's
2015
GTx (United States)
2014-2015
Abstract Background and Aims Acute heart failure (AHF) promotes inflammatory activation, which is associated with worse outcomes. Colchicine has proven effective in other cardiovascular conditions characterized by but never been evaluated the setting of AHF. Methods This multicenter, randomized, double-blind placebo-controlled trial included patients AHF, requiring ≥40 mg intravenous furosemide, regardless their left ventricular ejection fraction (LVEF) inpatient or outpatient setting....
We report that Aplidin, a novel antitumor agent of marine origin presently undergoing Phase II clinical trials, induced growth arrest and apoptosis in human MDA-MB-231 breast cancer cells at nanomolar concentrations. Aplidin specific cellular stress response program, including sustained activation the epidermal factor receptor (EGFR), non-receptor protein-tyrosine kinase Src, serine/threonine kinases JNK p38 MAPK. Aplidin-induced was only partially blocked by general caspase inhibitor...
Biotechnology provides sustainable solutions for soil and ecological deterioration resulting from human activities. This study investigated the biotechnological potential of strains isolated environmental samples collected in protected areas mines Honduras, focusing on their application producing biofertilizers bioremediation. 63 were from: soil, covers, mine waters, hot springs. From these, 118 bacterial characterized using microbiological molecular techniques. The genera Pseudomonas,...
Carbapenems are considered the last-resort antibiotics to treat infections caused by multidrug-resistant Gram-negative bacilli. The Klebsiella pneumoniae carbapenemase (KPC) enzyme hydrolyses β-lactam including carbapenems. KPC has been detected worldwide in Enterobacteriaceae and Pseudomonas aeruginosa isolates associated with transposon Tn4401 commonly located plasmids. Acinetobacter baumannii become an important nosocomial pathogen. KPC-producing A. reported date only Puerto Rico....
The human gamma-herpesviruses, Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus, establish lifelong latency in B cells are associated with multiple malignancies. Virus-host coevolution often drive changes both host immunity the viral genome. We consider one immune mechanism, activation-induced deaminase (AID)/APOBEC family of cytidine deaminases, that induces mutations DNA. AID, ancestral gene has a conserved role somatic hypermutation, key step antibody affinity maturation....
The relationship between the use of tobacco products and SARS-CoV-2 infection is poorly understood controversial. Few studies have examined effect electronic cigarettes (ECs) on infection. We tested hypothesis that EC fluids aerosols with nicotine promote SARS-COV-2 by increasing viral entry into human respiratory epithelial cells. Responses BEAS-2B cells to JUUL or their individual constituents were compared using three exposure platforms: submerged culture, air-liquid-interface (ALI) in a...
Riesz transforms $R_\mu$ related to the Bessel operators$$ \Delta_\mu=x^{-\mu-1/2}Dx^{2\mu+1}Dx^{-\mu-1/2} $$are studied in this work. We develop for a theory that runs parallel Euclidean Hilbert transform. It is proved actually Calderón–Zygmund singular integral operator. Also, seen be boundary value of appropriate harmonic extension context. Finally, we analyse weighted inequalities involving $R_\mu$.
Melanoma is the most aggressive skin cancer and a serious health problem worldwide because of its increasing incidence lack satisfactory chemotherapy for late stages disease. The marine depsipeptide Aplidin (plitidepsin) an antitumoral agent under phase II clinical development against several neoplasias, including melanoma. We report that plitidepsin has dual effect on human SK-MEL-28 UACC-257 melanoma cell lines; at low concentrations (≤45 nM), it inhibits cycle by inducing G<sub>1</sub>...
In recent years, silk fibroin nanoparticles (SFNs) have been consolidated as drug delivery systems (DDSs) with multiple applications in personalized medicine. The design of a simple, inexpensive, and scalable preparation method is an objective pursued by many research groups. When the to produce suitable for biomedical uses, their sterility essential. To achieve sufficient control all crucial stages process knowledge implications final characteristics nanoparticles, present work focused on...
Silk fibroin nanoparticles (SFN) have become a promising tool in drug delivery systems due to their physicochemical characteristics. SFN shown outstanding properties as an active vehicle for polyphenols, enhancing antioxidant and anti-inflammatory effects on macrophages; therefore, it becomes necessary easy, reproducible scalable production method. In order improve the of nanoparticles, we performed direct precipitation non-dialyzed silk solutions evaluated reproducibility method using...
We study lattice approximations of stochastic PDEs elliptic type, driven by a white noise on bounded domain in ℝ d , for = 1, 2, 3. obtain estimates the rate convergence approximations.
During a β-lactam resistance surveillance study, 12 IMP-18-positive Pseudomonas aeruginosa isolates belonging to 9 different pulsed-field gel electrophoresis groups were identified. In nine isolates, class I integron with novel gene array was identified that contained bla(IMP-18) and bla(OXA-224), while in two the bla(OXA-2) but new arrangement. Our findings show dissemination of integrons P. from regions Puerto Rico.
Febrile neutropenia is a common complication of chemotherapy treatment malignant hematological diseases. However, there insufficient information regarding the infectious complications febrile in our country. Objective. We will evaluate microbial characteristics bacterial and fungal isolates clinical outcome patients with who received medical attention at an oncological reference center Colombia.A prospective case series included histologically confirmed disease, were admitted because or...
In this paper we investigate Riesz transforms Rμ(k) of order k≥1 related to the Bessel operator Δμf(x)=-f”(x)-((2μ+1)/x)f’(x) and extend results Muckenhoupt Stein for conjugate Hankel transform (a one). We obtain that every k≥1, is a principal value strong type (p, p), p∈(1,∞), weak (1,1) with respect measure dλ(x)=x2μ+1 dx in (0,∞). also characterize class weights ω on (0,∞) which maps Lp(ω) into itself L1(ω) L1,∞(ω) boundedly. This wider than $\mathcal{A}_{p}^\mu$ doubling dλ. These...
Abstract In this paper we establish that Hankel multipliers of Laplace transform type are bounded from L p ( w ) into itself when 1 < ∞, and 1,∞ ), provided is in the Muckenhoupt class A on ((0,∞), dx ).