A5044108703- Diet and metabolism studies
- Pomegranate: compositions and health benefits
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Sesame and Sesamin Research
- Diabetes Management and Research
- Diabetes Management and Education
- Listeria monocytogenes in Food Safety
- Cynara cardunculus studies
- Phytochemicals and Antioxidant Activities
- Gastric Cancer Management and Outcomes
- Diabetes Treatment and Management
- Endoplasmic Reticulum Stress and Disease
- Colorectal Cancer Treatments and Studies
- Bariatric Surgery and Outcomes
- Fatty Acid Research and Health
- Digestive system and related health
- Chronic Disease Management Strategies
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds in Plants
- Probiotics and Fermented Foods
- Nutrition and Health in Aging
- Protein Tyrosine Phosphatases
- Polyamine Metabolism and Applications
Instituto Murciano de Investigación Biosanitaria
2021-2025
Biomedical Research Institute
2024
University College Cork
2018-2023
APC Microbiome Institute
2018-2023
Universidad de Murcia
2022
Centro de Edafología y Biología Aplicada del Segura
2013-2018
Quality Research
2018
Centre d'Etudes Biologiques de Chizé
2013-2018
National University of Ireland
2018
Consejo Superior de Investigaciones Científicas
2013-2018
Diabetes education has proved to be an essential tool in the care of patients with type 1 diabetes mellitus. To perform this educational task, VII Area Murcia East Unit, incorporated nurses advanced Hospital General Universitario Reina Sofía Murcia. We carried out a retrospective study, which assessed performance these by evaluating diabetic attending inquiries between 2007 and 2011. analyzed total 179 medical records, mellitus over 11 years, 103 (52.3%) males 94 (47.7%) women. Patients had...
Scope Urolithins are bioactive metabolites produced by the gut microbiota from ellagitannins (ETs) and ellagic acid (EA). We investigated whether urolithins could be detected in colon tissues colorectal cancer (CRC) patients after pomegranate extract (PE) intake. Methods results CRC (n = 52) were divided into controls PEs consumers (900 mg/day for 15 days) before surgical resection. with low (PE-1) high (PE-2) punicalagin:EA ratio administered. Twenty-three metabolites, but no ellagitannins,...
Ellagic acid (EA) is a polyphenol that must be released from the non-bioavailable ellagitannins in pomegranates, walnuts or strawberries to absorbed. To estimate whether EA bioavailability could improved after consumption of high free amount, we conducted crossover pharmacokinetic study healthy volunteers consumed two pomegranate extracts providing either 130 mg punicalagin+524 (PE-1) 279 punicalagin+25 (PE-2). Targeted metabolomics (UPLC-ESI-qTOF-MS/MS) identified plasma but not phase-II...
Oxidative stress is involved in cell death neurodegenerative diseases. Dietary polyphenols can exert health benefits, but their direct effects on neuronal cells are debatable because most phenolics metabolized and do not reach the brain as they occur dietary sources. Herein, we evaluate of a panel bioavailable derived metabolites at physiologically relevant conditions against H2O2-induced apoptosis human neuroblastoma SH-SY5Y cells. Among 19 tested, 3,4-dihydroxyphenylpropionic acid,...
Abstract Context Metabolic dysfunction–associated steatotic liver disease (MASLD) is characterized by the intracellular lipid accumulation in hepatocytes. Excess caloric intake and high-fat diets are considered to significantly contribute MASLD development. Objective To evaluate hepatic serum fatty acid (FA) composition patients with different stages of MASLD, their relationship FA dietary MASLD-related risk factors. Methods This was a case–control study obesity undergoing bariatric surgery...
The global prevalence of Metabolic Dysfunction-Associated Steatohepatitis (MASH) has been rising sharply, closely mirroring the increasing rates obesity and metabolic syndrome. MASH exhibits a strong sexual dimorphism where females are affected with more severe forms after menopause. Hexokinase domain-containing protein 1 (HKDC1) recently recognized for its role in liver diseases, expression is minimal under normal conditions but significantly increases response to stressors like injury....
Ellagitannins, ellagic acid, and the colonic metabolites urolithins (Uros) exhibit anticancer effects against colon cells, but a comprehensive molecular analysis has not been done. Herein, we used panel of cell lines to first time evaluate antiproliferative properties accompanying responses two ellagitannin mixtures mimicking situation in vivo each individual metabolite.We examined growth, cycle, apoptosis, expression related genes microRNAs (miRs) nonmalignant malignant lines. Regardless...
MicroRNAs (miRs) are proposed as colorectal cancer (CRC) biomarkers. Pomegranate ellagic acid and their microbiota metabolites urolithins exert anticancer effects in preclinical CRC models, target normal malignant colon tissues patients. Herein, we investigated whether the intake of pomegranate extract (PE) modified miRs expression surgical versus biopsies from patients.We conducted a randomized, double-blind, controlled trial. Thirty-five patients consumed 900 mg PE daily before surgery....
Abstract Objective Alterations in the hepatic lipidome are a crucial factor involved pathophysiology of nonalcoholic fatty liver disease (NAFLD). The aim this study was to evaluate serum and profile branched‐chain acids (BCFAs) patients with different stages NAFLD. Methods This case–control performed 27 without NAFLD, 49 liver, 17 steatohepatitis, defined by biopsies. Serum levels BCFAs were analyzed gas chromatography–mass spectrometry. expression genes endogenous synthesis real‐time...
Consumption of pomegranate decreases, in a time-dependent fashion, metabolic endotoxemia patients with newly diagnosed colorectal cancer.
A high-fat (HF) diet reduces resistance to the foodborne pathogen Listeria monocytogenes. We demonstrate that short-term gavage with A. muciniphila increases oral and systemic L. monocytogenes infection in mice fed a HF diet. reduced inflammation gut liver of prior inflammatory cell infiltration ileum levels similar low-fat (LF) Akkermansia administration had minimal impacts upon microbiota microbial metabolites did not affect individual taxa or impact Bacteroidetes Firmicutes ratio. In...
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a chronic condition that often progresses to more advanced stages, such as metabolic steatohepatitis (MASH). MASH characterized by inflammation and hepatocellular ballooning, in addition hepatic steatosis. Despite the relatively high incidence of population its potential detrimental effects on human health, this still not fully understood from pathophysiological perspective. Deregulation polyamine levels has been...
Metabolic syndrome (MetS), a global epidemic induced by poor dietary habits refers to complex metabolic disorder that includes, among others, alterations in the gut microbiome. Because of high costs associated with long-term management MetS, development non-pharmacological approaches has attracted great attention from food companies. Generation synbiotics is one promising strategy ameliorate various aspects related MetS. However, high-quality interventional clinical trials addressing effects...
Silk fibroin nanoparticles (SFN) have become a promising tool in drug delivery systems due to their physicochemical characteristics. SFN shown outstanding properties as an active vehicle for polyphenols, enhancing antioxidant and anti-inflammatory effects on macrophages; therefore, it becomes necessary easy, reproducible scalable production method. In order improve the of nanoparticles, we performed direct precipitation non-dialyzed silk solutions evaluated reproducibility method using...