A5027248909- Phytochemicals and Antioxidant Activities
- Pomegranate: compositions and health benefits
- Antioxidant Activity and Oxidative Stress
- Sirtuins and Resveratrol in Medicine
- Nutritional Studies and Diet
- Biofuel production and bioconversion
- Consumer Attitudes and Food Labeling
- Natural Antidiabetic Agents Studies
- Sesame and Sesamin Research
- Biochemical Analysis and Sensing Techniques
- Obesity, Physical Activity, Diet
- Polysaccharides and Plant Cell Walls
- Microbial Metabolites in Food Biotechnology
- Adipokines, Inflammation, and Metabolic Diseases
- Free Radicals and Antioxidants
- Tea Polyphenols and Effects
- Nutrition, Genetics, and Disease
- Cynara cardunculus studies
- Diet and metabolism studies
- Tannin, Tannase and Anticancer Activities
- Enzyme Production and Characterization
- Phytase and its Applications
- Natural product bioactivities and synthesis
- Saffron Plant Research Studies
- Ginkgo biloba and Cashew Applications
Centro de Edafología y Biología Aplicada del Segura
2015-2024
Consejo Superior de Investigaciones Científicas
2014-2024
Centre d'Etudes Biologiques de Chizé
2013
Quadram Institute
1996-2008
Norwich Research Park
1996-2008
Technical University of Munich
2003
The health benefits attributed to pomegranate have been associated with its high content in polyphenols, particularly ellagitannins. This is also the case for other ellagitannin-containing fruits and nuts including strawberry, raspberry, blackberry, walnuts, muscadine grapes. bioavailability of ellagitannins ellagic acid however very low. These molecules suffer extensive metabolism by gut microbiota produce urolithins that are much better absorbed. Urolithins circulate plasma as glucuronide...
Short‐chain fatty acids are the major end products of bacterial metabolism in large bowel. They derive mostly from breakdown carbohydrates and known to have positive health benefits. Due biological relevance these compounds it is important develop efficient, cheap, fast, sensitive analytical methods that enable identification quantification short‐chain a number samples. In this study, gas chromatography‐mass spectrometry method was developed validated for analysis faecal These volatile were...
The grape and wine polyphenol resveratrol exerts cardiovascular benefits but evidence from randomized human clinical trials is very limited. We investigated dose-depending effects of a resveratrol-containing supplement on stable patients with coronary artery disease (CAD) treated according to currently accepted guidelines for secondary prevention disease.In triple-blind, randomized, placebo-controlled, one-year follow-up, 3-arm pilot trial, 75 stable-CAD received 350 mg/day placebo, extract...
This study provides comprehensive validation of the 14-item Mediterranean Diet Adherence Screener (14-MEDAS) in an adult population from Greece (GR), Portugal (PT), Italy (IT), Spain (SP), Cyprus (CY), Republic North Macedonia (NMK), and Bulgaria (BG). A moderate association between 14-MEDAS reference food diary was estimated for entire (Pearson r = 0.573, p-value < 0.001; Intraclass Correlation Coefficient (ICC) 0.692, 0.001) with strongest correlation found GR, followed by PT, IT, SP,...
Hydroxycinnamic acids are effective antioxidants and abundant components of plant cell walls, especially in cereal bran. For example, wheat rye brans rich sources the hydroxycinnamates ferulic acid, sinapic p-coumaric acid. These phenolics part human animal diets may contribute to beneficial effects derived from consumption However, these compounds ester linked main polymers wall cannot be absorbed this complex form. The present work shows that esterases with activity toward esters major...
Urolithins A and B (hydroxy-6H-dibenzo[b,d]pyran-6-one derivatives) are colonic microflora metabolites recently proposed as biomarkers of human exposure to dietary ellagic acid derivatives. Molecular models suggest that urolithins could display estrogenic and/or antiestrogenic activity. To this purpose, both other known phytoestrogens (genistein, daidzein, resveratrol, enterolactone) were assayed evaluate the capacity induce cell proliferation on estrogen-sensitive breast cancer MCF-7 cells...
Hydroxycinnamic acids are a group of phenolic compounds that exhibit wide range in vitro chemoprotective and antioxidant properties. Cereals containing high proportion the bran layers rich ester-linked hydroxycinnamic acids, such as ferulic diferulic acids. The present work investigated absorption humans from high-bran breakfast cereal (wheat). Plasma urine samples six volunteers were collected before after consumption analyzed for total content beta-glucuronidase/sulfatase treatment both by...
Epidemiology supports the important role of nutrition in prostate cancer (PCa) prevention. Pomegranate juice (PJ) exerts protective effects against PCa, mainly attributed to PJ ellagitannins (ETs). Our aim was assess whether ETs or their metabolites ellagic acid and urolithins reach human upon consumption ET-rich foods evaluate effect on expression three proliferation biomarkers. Sixty-three patients with BPH PCa were divided into controls consumers walnuts (35 g walnuts/day) pomegranate...
Scope The cardioprotective role of resveratrol as part the human diet is not yet clear. Our aim was to investigate effect a grape supplement containing 8 mg in oxidized LDL ( ox), apolipoprotein‐ B A po ), and serum lipids on statin‐treated patients primary cardiovascular disease prevention PCP ). Methods results triple‐blind, randomized, placebo‐controlled trial conducted. Seventy‐five (three parallel arms) consumed one capsule (350 mg) daily for 6 months resveratrol‐enriched extract GE ‐...
Scope Numerous in vitro and vivo studies indicate that ellagitannins exhibit anti‐inflammatory, anti‐atherosclerotic anti‐angiogenic activity which support their potential preventive effect against cardiovascular diseases. Ellagitannins low bioavailability are transformed the gut to ellagic acid its microbiota metabolites urolithin A (Uro‐A) B (Uro‐B). Urolithins found plasma mostly as glucuronides at μ M concentrations. We investigated whether aglycones vascular protective effects. Methods...
Novel gene expression profiles and cellular functions modulated in Caco-2 cells response to the dietary polyphenol, ellagic acid (EA), its colonic metabolites, urolithin-A (3,8-dihydroxy-6H-dibenzo[b,d] pyran-6-one) urolithin-B (3-hydroxy-6H-dibenzo[b,d] have been identified. Exposure of EA urolithins arrested cell growth at S- G(2)/M-phases. Transcriptional profiling using microarray functional analysis revealed changes levels MAPK signalling genes such as, factor receptors (FGFR2, EGFR),...
Orange juice is a very rich source of dietary flavanones. The effect flavanone concentration and solubility orange beverages on their bioavailability has been studied in crossover study with 10 healthy volunteers. Five different concentrations were evaluated. Commercial juices (29.2−70.3 mg flavanones/100 mL) compared experimental which the was enhanced (110.2 mg/100 mL). Hesperetin naringenin glucuronides sulfates detected quantified plasma urine. shows that flavanones, particularly...
Flavanones, flavonoids abundant in Citrus, have been shown to interfere with quorum sensing (QS) and affect related physiological processes. We investigated the QS-inhibitory effects of an orange extract enriched O-glycosylated flavanones (mainly naringin, neohesperidin, hesperidin). The capacity this its main flavanone components was first screened using bacteriological monitoring system Chromobacterium violaceum. next examined ability some (i) reduce levels QS mediators produced by Y....
Abstract Scope : trans ‐Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism and tissue distribution of RES using pig, a mammal physiologically close humans. Methods results Forty‐seven tissues, organs fluids were analyzed 6 h after intragastric administration (5.9 mg/kg body weight) HPLC‐MS/MS. Twelve seven dihydroresveratrol (DH‐RES) detected. DH‐RES main metabolite cecum, colon rectum, whereas RES‐3‐ O ‐glucuronide most abundant one...