A5003870711- Pomegranate: compositions and health benefits
- Botulinum Toxin and Related Neurological Disorders
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Phytochemicals and Antioxidant Activities
- Cynara cardunculus studies
- Curcumin's Biomedical Applications
- Microbial Metabolites in Food Biotechnology
- Angiogenesis and VEGF in Cancer
- Food composition and properties
- Neurological disorders and treatments
- Sesame and Sesamin Research
- Seed and Plant Biochemistry
- Amoebic Infections and Treatments
- Antioxidant Activity and Oxidative Stress
- Hepatitis B Virus Studies
- Diphtheria, Corynebacterium, and Tetanus
- Toxin Mechanisms and Immunotoxins
- Biochemical and Structural Characterization
- Parkinson's Disease Mechanisms and Treatments
- Bioactive Compounds in Plants
- Streptococcal Infections and Treatments
- Analytical Chemistry and Chromatography
- Ginkgo biloba and Cashew Applications
- Retinoids in leukemia and cellular processes
Centro de Edafología y Biología Aplicada del Segura
2011-2024
Vanderbilt University
2016-2023
Consejo Superior de Investigaciones Científicas
2009-2022
Centre d'Etudes Biologiques de Chizé
2013-2022
Institute of Animal Reproduction and Food Research
2015-2021
Vanderbilt University Medical Center
2017-2019
Quality Research
2019
Polish Academy of Sciences
2015-2018
Nashville Oncology Associates
2018
Centro Médico Sanitas Murcia
2015
Short‐chain fatty acids are the major end products of bacterial metabolism in large bowel. They derive mostly from breakdown carbohydrates and known to have positive health benefits. Due biological relevance these compounds it is important develop efficient, cheap, fast, sensitive analytical methods that enable identification quantification short‐chain a number samples. In this study, gas chromatography‐mass spectrometry method was developed validated for analysis faecal These volatile were...
Epidemiology supports the important role of nutrition in prostate cancer (PCa) prevention. Pomegranate juice (PJ) exerts protective effects against PCa, mainly attributed to PJ ellagitannins (ETs). Our aim was assess whether ETs or their metabolites ellagic acid and urolithins reach human upon consumption ET-rich foods evaluate effect on expression three proliferation biomarkers. Sixty-three patients with BPH PCa were divided into controls consumers walnuts (35 g walnuts/day) pomegranate...
Scope Numerous in vitro and vivo studies indicate that ellagitannins exhibit anti‐inflammatory, anti‐atherosclerotic anti‐angiogenic activity which support their potential preventive effect against cardiovascular diseases. Ellagitannins low bioavailability are transformed the gut to ellagic acid its microbiota metabolites urolithin A (Uro‐A) B (Uro‐B). Urolithins found plasma mostly as glucuronides at μ M concentrations. We investigated whether aglycones vascular protective effects. Methods...
Flavanones, flavonoids abundant in Citrus, have been shown to interfere with quorum sensing (QS) and affect related physiological processes. We investigated the QS-inhibitory effects of an orange extract enriched O-glycosylated flavanones (mainly naringin, neohesperidin, hesperidin). The capacity this its main flavanone components was first screened using bacteriological monitoring system Chromobacterium violaceum. next examined ability some (i) reduce levels QS mediators produced by Y....
Caffeic acid is one of the most abundant hydroxycinnamic acids in fruits, vegetables, and beverages. This phenolic compound reaches relevant concentrations colon (up to 126 µM) where it could come into contact with intestinal cells exert its anti-inflammatory effects. The aim this investigation was study capacity caffeic acid, at plausible from an vivo point view, modulate mechanisms related inflammation. Consequently, we tested effects (50–10 on cyclooxygenase (COX)-2 expression...
Plant-derived food consumption has gained attention as potential intervention for the improvement of intestinal inflammatory diseases. Apple been shown to be effective at ameliorating inflammation symptoms. These beneficial effects have related (poly)phenols, including phloretin (Phlor) and its glycoside named phloridzin (Phldz). To deepen modulatory these molecules we studied: i) their influence on synthesis proinflammatory (PGE2, IL-8, IL-6, MCP-1, ICAM-1) in IL-1β-treated myofibroblasts...
The consumption of pomegranate juices and extracts has long been linked to many health benefits beyond nutrition, described mainly by innumerable preclinical studies. However, the European Food Safety Authority (EFSA) concluded in 2010 that a cause effect relationship could not be established between pomegranate-derived products all claims presented. There are no additional EFSA opinions on specifically addressed last decade. This review comprehensively compiles human studies conducted...
Some polyphenol-derived metabolites reach human breast cancer (BC) tissues at concentrations that induce cell senescence. However, this is unknown for isoflavones, curcuminoids, and lignans. Here, their metabolic profiling in normal (NT) malignant (MT) mammary of newly-diagnosed BC patients the tissue-occurring metabolites' anticancer activity are evaluated.Patients (n = 26) consumed 3 capsules/day (turmeric, red clover, flaxseed extracts plus resveratrol; 296.4 mg phenolics/capsule) from...
Pomegranate ellagitannins (ETs) are transformed in the gut to ellagic acid (EA) and its microbiota metabolites, urolithin A (Uro-A) B (Uro-B). These compounds exert anti-inflammatory effects vitro vivo. The aim of this study was investigate Uro-A, Uro-B, EA on colon fibroblasts, cells that play a key role intestinal inflammation. CCD18-Co fibroblasts were exposed mixture EA, at concentrations comparable those found (40 μM 5 1 EA), both presence or absence IL-1β (1 ng/mL) TNF-α (50 ng/mL),...
Abstract Human serum albumin (HSA) is the most abundant protein, contributing to maintenance of redox balance in extracellular fluids. One single free cysteine residue at position 34 believed be a target oxidation. However, molecular details and functions oxidized HSAs remain obscure. Here we analyzed samples from normal subjects hyperlipidemia patients observed an enhanced S -thiolation HSA as compared control individuals. Both homocysteine were identified low weight thiols bound HSAs....
Scope Recent evidence demonstrates that resveratrol (RSV) metabolites, but not free RSV, reach malignant tumors (MT) in breast cancer (BC) patients. Since these as detected MT, do exert short‐term antiproliferative or estrogenic/antiestrogenic activities, long‐term tumor‐senescent chemoprevention has been hypothesized. Consequently, here, for the first time, whether physiologically relevant RSV metabolites can induce senescence BC cells is investigated. Methods and Results Human MCF‐7...
The intake of hesperidin-rich sources, mostly found in orange juice, can decrease cardiometabolic risk, potentially linked to the gut microbial phase-II hesperetin derivatives. However, low hesperidin solubility hampers its bioavailability and metabolism, yielding a high inter-individual variability (high vs. low-producers) that prevents consistent health-related evidence. Contrarily, human metabolism (lemon) eriocitrin is hardly known. We hypothesize higher (orange) might yield more...
Epidemiological, clinical and preclinical studies have reported the protection offered by citrus consumption, mainly orange, against cardiovascular diseases, which is primarily mediated antiatherogenic vasculoprotective effects of flavanone hesperetin-7-O-rutinoside (hesperidin). However, aglycones or glycosides are not present in bloodstream but their derived phase-II metabolites could be actual bioactive molecules. To date, only a few explored circulating hesperetin-derived (glucuronides...