A5057639279- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Curcumin's Biomedical Applications
- Moringa oleifera research and applications
- IL-33, ST2, and ILC Pathways
- Nutrition and Health in Aging
- Cannabis and Cannabinoid Research
- Polyamine Metabolism and Applications
- Silk-based biomaterials and applications
- Gut microbiota and health
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
Instituto Murciano de Investigación Biosanitaria
2022-2024
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a chronic condition that often progresses to more advanced stages, such as metabolic steatohepatitis (MASH). MASH characterized by inflammation and hepatocellular ballooning, in addition hepatic steatosis. Despite the relatively high incidence of population its potential detrimental effects on human health, this still not fully understood from pathophysiological perspective. Deregulation polyamine levels has been...
Silk fibroin nanoparticles (SFN) have become a promising tool in drug delivery systems due to their physicochemical characteristics. SFN shown outstanding properties as an active vehicle for polyphenols, enhancing antioxidant and anti-inflammatory effects on macrophages; therefore, it becomes necessary easy, reproducible scalable production method. In order improve the of nanoparticles, we performed direct precipitation non-dialyzed silk solutions evaluated reproducibility method using...
Chronic inflammatory diseases pose a substantial health challenge globally, significantly contributing to morbidity and mortality. Addressing this issue requires the use of effective anti-inflammatory strategies with fewer side effects than those provoked by currently used drugs. In study, range phytochemicals (phenolic di-caffeoylquinic acid (Di-CQA), flavonoid cyanidin-3,5-diglucoside (Cy3,5DiG), aromatic isothiocyanate sinalbin (SNB) aliphatic sulforaphane (SFN)) sourced from vegetables...
Cruciferous vegetables have been reported to be a great source of anti-inflammatory compounds. Specifically, sprouts from the Brassicaceae family stand out for their high content glucosinolates (and bioactive derivatives, isothiocyanates), phenolic acids, and anthocyanins. Despite evident activity certain Brassica phytochemicals such as sulforaphane or effect digested on inflammation remains understudied. In this work, we aimed evaluate potential bioaccessible forms cruciferous bioactives...
Objectives: Deregulation of amino acid (AA) metabolism has been reported in various pathological conditions, including metabolic diseases (obesity and diabetes), cardiovascular diseases, autoimmune neurological disorders, cancer. However, the role alterations AA levels chronic liver disorders commonly related to excess caloric consumption, unhealthy diet, sedentary lifestyle, dysfunction-associated steatotic disease (MASLD) remains largely unexplored. Despite relatively high incidence MASLD...
ABSTRACT Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent cause of worldwide. This progressive condition ranges from simple steatosis to a more advanced stage, known as metabolic steatohepatitis (MASH), which characterized by inflammation, hepatocellular ballooning, and hepatic steatosis. Several studies have demonstrated involvement inflammasomes in MASH development. Recently, NLRP1 inflammasome has gained attention an important sensor various human...
Colorectal cancer (CRC) is the third most common and second cause of death worldwide. Several factors have been postulated to be involved in CRC pathophysiology, including heritable environmental factors, which are latest closely associated with nutritional habits, physical activity, obesity, gut microbiota. The latter may also play a key role prognosis derived complications patients undergoing surgery. This single-center, open, controlled, randomized clinical trial, scheduled surgical...