A5068187888- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Genomics, phytochemicals, and oxidative stress
- Gut microbiota and health
- Fatty Acid Research and Health
- Curcumin's Biomedical Applications
- Bariatric Surgery and Outcomes
- Cannabis and Cannabinoid Research
- Liver Disease and Transplantation
- Cardiovascular Disease and Adiposity
- Polyamine Metabolism and Applications
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Enhanced Recovery After Surgery
- Gallbladder and Bile Duct Disorders
- Glutathione Transferases and Polymorphisms
- Silk-based biomaterials and applications
- Inflammatory mediators and NSAID effects
- Electrospun Nanofibers in Biomedical Applications
- Peroxisome Proliferator-Activated Receptors
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
Instituto Murciano de Investigación Biosanitaria
2021-2024
Universidad de Murcia
2022-2023
Instituto de Investigación Biomédica de Málaga
2020
Abstract Context Metabolic dysfunction–associated steatotic liver disease (MASLD) is characterized by the intracellular lipid accumulation in hepatocytes. Excess caloric intake and high-fat diets are considered to significantly contribute MASLD development. Objective To evaluate hepatic serum fatty acid (FA) composition patients with different stages of MASLD, their relationship FA dietary MASLD-related risk factors. Methods This was a case–control study obesity undergoing bariatric surgery...
Abstract Objective Alterations in the hepatic lipidome are a crucial factor involved pathophysiology of nonalcoholic fatty liver disease (NAFLD). The aim this study was to evaluate serum and profile branched‐chain acids (BCFAs) patients with different stages NAFLD. Methods This case–control performed 27 without NAFLD, 49 liver, 17 steatohepatitis, defined by biopsies. Serum levels BCFAs were analyzed gas chromatography–mass spectrometry. expression genes endogenous synthesis real‐time...
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a chronic condition that often progresses to more advanced stages, such as metabolic steatohepatitis (MASH). MASH characterized by inflammation and hepatocellular ballooning, in addition hepatic steatosis. Despite the relatively high incidence of population its potential detrimental effects on human health, this still not fully understood from pathophysiological perspective. Deregulation polyamine levels has been...
Chronic inflammatory diseases are major causes of global morbidity and mortality. Acute inflammation is meant to protect the body against foreign agents, but it also plays a role in tissue repairment. Several mediators involved this process, including pro-inflammatory cytokines produced by macrophages. Occasionally, if response not resolved, acute process can evolve into chronic inflammation. Natural compounds from vegetables considered as an important source active agents with potential...
Silk fibroin nanoparticles (SFN) have become a promising tool in drug delivery systems due to their physicochemical characteristics. SFN shown outstanding properties as an active vehicle for polyphenols, enhancing antioxidant and anti-inflammatory effects on macrophages; therefore, it becomes necessary easy, reproducible scalable production method. In order improve the of nanoparticles, we performed direct precipitation non-dialyzed silk solutions evaluated reproducibility method using...
Associations between dyslipidemia and metabolic dysfunction-associated steatotic liver disease (MASLD) have been reported. Previous studies shown that the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio may be a surrogate marker of MASLD, assessed by ultrasound. However, no evaluated utility this according biopsy-proven MASLD its stages. Therefore, our aim was evaluate if TG/HDL-C allows for identification in patients with obesity. We conducted case-control study 153...
Acute myeloid leukemia (AML) is a cancer of the blood cells mainly treated with chemotherapy for remission, but this non-selective treatment also induces numerous side effects. Investigations bioactive compounds from plant-derived foods against have increased in last years because there an urgent need to search new anti-leukemic agents possessing higher efficacy and selectivity AML fewer negative In study, we analyzed activity several phytochemicals that are representative major classes...
Cruciferous vegetables have been reported to be a great source of anti-inflammatory compounds. Specifically, sprouts from the Brassicaceae family stand out for their high content glucosinolates (and bioactive derivatives, isothiocyanates), phenolic acids, and anthocyanins. Despite evident activity certain Brassica phytochemicals such as sulforaphane or effect digested on inflammation remains understudied. In this work, we aimed evaluate potential bioaccessible forms cruciferous bioactives...
Objectives: Deregulation of amino acid (AA) metabolism has been reported in various pathological conditions, including metabolic diseases (obesity and diabetes), cardiovascular diseases, autoimmune neurological disorders, cancer. However, the role alterations AA levels chronic liver disorders commonly related to excess caloric consumption, unhealthy diet, sedentary lifestyle, dysfunction-associated steatotic disease (MASLD) remains largely unexplored. Despite relatively high incidence MASLD...
ABSTRACT Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent cause of worldwide. This progressive condition ranges from simple steatosis to a more advanced stage, known as metabolic steatohepatitis (MASH), which characterized by inflammation, hepatocellular ballooning, and hepatic steatosis. Several studies have demonstrated involvement inflammasomes in MASH development. Recently, NLRP1 inflammasome has gained attention an important sensor various human...
Colorectal cancer (CRC) is the third most common and second cause of death worldwide. Several factors have been postulated to be involved in CRC pathophysiology, including heritable environmental factors, which are latest closely associated with nutritional habits, physical activity, obesity, gut microbiota. The latter may also play a key role prognosis derived complications patients undergoing surgery. This single-center, open, controlled, randomized clinical trial, scheduled surgical...