Francisco J. Tinahones
A5061677162- Diet and metabolism studies
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Gut microbiota and health
- Metabolism, Diabetes, and Cancer
- Obesity, Physical Activity, Diet
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bariatric Surgery and Outcomes
- Cardiovascular Disease and Adiposity
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Nutrition and Health in Aging
- Lipoproteins and Cardiovascular Health
- Eating Disorders and Behaviors
- Fatty Acid Research and Health
- Health and Lifestyle Studies
- Diabetes and associated disorders
- Dietary Effects on Health
- Atherosclerosis and Cardiovascular Diseases
Hospital Clínico Universitario Virgen de la Victoria
2016-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2016-2025
Instituto de Salud Carlos III
2016-2025
Universidad de Málaga
2016-2025
Instituto de Investigación Biomédica de Málaga
2016-2025
Centro de Investigación Biomédica en Red
2016-2025
Andalusian Centre for Nanomedicine and Biotechnology
2023-2025
Universitat de les Illes Balears
2024
Biomedical Research Institute
2024
Universitat Jaume I
2024
Context: Recently irisin (encoded by Fndc5 gene) has been reported to stimulate browning and uncoupling protein 1 expression in sc adipose tissue of mice. Objective: The objective the study was investigate FNDC5 gene human muscle circulating according obesity, insulin sensitivity, type 2 diabetes. Design, Patients, Main Outcome Measure: Adipose (ELISA) were analyzed different cohorts (n = 125 n 76); also evaluated a subcohort 34 subjects. In vitro studies preadipocytes adipocytes induced...
A recent study using a rat model found significant differences at the time of diabetes onset in bacterial communities responsible for type 1 modulation. We hypothesized that humans could also be linked to specific gut microbiota. Our aim was quantify and evaluate difference composition microbiota between children with healthy determine possible relationship glycemic level.A case-control carried out 16 children. The fecal bacteria investigated by polymerase chain reaction-denaturing gradient...
Several evidences indicate that gut microbiota is involved in the control of host energy metabolism.To evaluate differences composition rat models under different nutritional status and physical activity to identify their associations with serum leptin ghrelin levels.In a case study, forty male rats were randomly assigned one these four experimental groups: ABA group food restriction free access exercise; no exercise feed ad libitum without libitum. The fecal bacteria was investigated by...
OBJECTIVE The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body and risk factors PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a trial designed to evaluate the effectiveness an intensive lifestyle intervention primary prevention. RESEARCH DESIGN AND METHODS Overweight/obese adults with metabolic syndrome aged 55–75 years (n = 626) were randomized based energy-restricted Mediterranean diet, physical activity...
Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, type 2 diabetes. We aimed to analyze systemic levels of succinate obesity, major risk factor CVD, its relationship with gut microbiome. explored association circulating specific metagenomic signatures cross-sectional prospective cohorts Caucasian Spanish...
This study evaluated the possible prebiotic effect of a moderate intake red wine polyphenols on modulation gut microbiota composition and improvement in risk factors for metabolic syndrome obese patients. Ten patients ten healthy subjects were included randomized, crossover, controlled intervention study. After washout period, consumed de-alcoholized over 30 day period each. The dominant bacterial did not differ significantly between groups after two periods. In patients, increased number...
Gut microbiota, which acts collectively as a fully integrated organ in the host metabolism, can be shaped by long-term dietary interventions after specific diet.The aim was to study changes microbiota 1 year's consumption of Mediterranean diet (Med diet) or low-fat, high-complex carbohydrate (LFHCC an obese population.Participants were randomized receive Med (35% fat, 22% monounsaturated) and LFHCC (28% 12% monounsaturated).The conducted 20 patients (men) within Coronary Diet Intervention...
CHD, coronary heart disease;d, day; erMedDiet, energy-reduced Mediterranean diet (based on the 17-item questionnaire); MedDiet, 14-item 44,45 E, energy intake; LDL, low
We assessed whether intermittent hypoxia, which emulates one of the hallmarks obstructive sleep apnoea (OSA), leads to altered faecal microbiome in a murine model. In vivo partial pressure oxygen was measured colonic faeces during hypoxia four anesthetised mice. 10 mice were subjected pattern chronic (20 s at 5% O 2 and 40 room air for 6 h·day −1 ) weeks served as normoxic controls. Faecal samples obtained composition determined by 16S rRNA pyrosequencing bioinformatic analysis Quantitative...
OBJECTIVE Type 1 diabetes is associated with compositional differences in gut microbiota. To date, no microbiome studies have been performed maturity-onset of the young 2 (MODY2), a monogenic cause diabetes. Gut microbiota type diabetes, MODY2, and healthy control subjects was compared. RESEARCH DESIGN AND METHODS This case-control study 15 children 13 children. Metabolic potential factors modifying were controlled. Microbiome composition determined by 16S rRNA pyrosequencing. RESULTS...
Background Extreme weight conditions (EWC) groups along a continuum may share some biological risk factors and intermediate neurocognitive phenotypes. A core cognitive trait in EWC appears to be executive dysfunction, with focus on decision making, response inhibition flexibility. Differences between individuals these areas are likely contribute the differences vulnerability EWC. The aim of study was investigate whether there is common pattern dysfunction while comparing anorexia nervosa...
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin circulating elevated obese subjects. The aim this study was to evaluate levels conditions extreme BMI its correlation with basal metabolism daily activity. involved 145 female patients, including 96 BMIs (30 anorexic (AN) 66 (OB)) 49 healthy normal weight (NW)....
El objetivo principal de este documento internacional consenso sobre apnea obstructiva del sueño es proporcionar unas directrices que permitan a los profesionales sanitarios tomar las mejores decisiones en la asistencia pacientes adultos con esta enfermedad según un resumen crítico literatura más actualizada. grupo trabajo expertos se ha constituido principalmente por 17 sociedades científicas y 56 especialistas amplia representación geográfica (con participación 4 internacionales), además...
This study assessed the effects of glucagon-like peptide-1 (GLP-1)/glucagon receptor co-agonist efinopegdutide relative to selective GLP-1 agonist semaglutide on liver fat content (LFC) in patients with non-alcoholic fatty disease (NAFLD).This was a phase IIa, randomized, active-comparator-controlled, parallel-group, open-label study. A magnetic resonance imaging-estimated proton density fraction assessment performed determine LFC at screening and Week 24. Participants an ≥10% were...
To determine whether semaglutide slows progression of glycemia in people with cardiovascular disease and overweight or obesity but without diabetes.
Abstract Objective. The antiphospholipid syndrome (APS) is a disorder of recurrent thrombosis, pregnancy loss, and thrombocytopenia associated with the production anticardiolipin antibodies (aCL) lupus anticoagulant (LAC). mechanisms thrombus formation remain unknown. Tissue factor (TF), an inducible cell glycoprotein, major initiator coagulation in vivo. present study was therefore undertaken to investigate TF expression procoagulant activity on monocytes from patients primary APS its...
Abstract Objectives : The aims of our study were to examine the lifetime prevalence obesity rate in eating disorders (ED) subtypes and whether there have been temporal changes among last 10 years explore clinical differences between ED with without obesity. Methods Participants 1383 female patients (DSM‐IV criteria) consecutively admitted, 2001 2010, Bellvitge University Hospital. They assessed by means Eating Disorders Inventory‐2, Symptom Checklist‐90—Revised, Bulimic Investigatory Test...