A5107117518- Frailty in Older Adults
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac Health and Mental Health
- Cardiac tumors and thrombi
- Cardiac Structural Anomalies and Repair
- Cardiovascular and exercise physiology
- Eosinophilic Disorders and Syndromes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Long-Term Effects of COVID-19
- Lipoproteins and Cardiovascular Health
- Acute Ischemic Stroke Management
- Pericarditis and Cardiac Tamponade
- Cardiovascular and Diving-Related Complications
- Nursing care and research
- Aging, Health, and Disability
Centro de Investigación en Red en Enfermedades Cardiovasculares
2018-2025
Hospital Universitari Germans Trias i Pujol
2015-2025
Centro de Investigación Biomédica en Red
2024
Universitat Autònoma de Barcelona
2011-2016
Vall d'Hebron Hospital Universitari
2009
To our knowledge, no randomized clinical trial has compared the invasive and conservative strategies in frail, older patients with non-ST-segment elevation acute myocardial infarction (NSTEMI).
Importance The MOSCA-FRAIL randomized clinical trial compared invasive and conservative treatment strategies in patients with frailty non–ST-segment elevation myocardial infarction (NSTEMI). It showed no differences the number of days alive out hospital at 1 year. Objective To assess outcomes during extended follow-up. Design, Setting, Participants was conducted 13 hospitals Spain between July 7, 2017, January 9, 2021, included 167 adults (aged ≥70 years) (Clinical Frailty Scale score ≥4)...
Abstract Background and Aims Acute heart failure (AHF) promotes inflammatory activation, which is associated with worse outcomes. Colchicine has proven effective in other cardiovascular conditions characterized by but never been evaluated the setting of AHF. Methods This multicenter, randomized, double-blind placebo-controlled trial included patients AHF, requiring ≥40 mg intravenous furosemide, regardless their left ventricular ejection fraction (LVEF) inpatient or outpatient setting....
Abstract The IFFANIAM study (Impact of frailty and functional status in elderly patients with ST segment elevation myocardial infarction undergoing primary angioplasty) is an observational multicenter registry to assess the impact on outcomes ‐segment ( STEMI ) angioplasty. age 75 years or older angioplasty will be extensively studied during admission 4 tertiary care Hospitals Spain, assessing their baseline (Barthel index, Lawton‐Brody index), (Fried criteria, FRAIL scale [fatigue,...
Background Clinical trials and meta-analyses indicate a reduced reinfarction risk with invasive management in older patients non-ST-segment elevation myocardial infarction (NSTEMI). This study investigated whether similar benefits might be observed frail patients. Methods The coMOrbilidades Síndrome Coronario Agudo - FRAIL (MOSCA-FRAIL) trial included 167 adults aged ≥70 years frailty (Clinical Frailty Scale ≥4 points) NSTEMI, who were randomised to (n=84) or conservative (n=83) strategy...
Bleeding risk scores have shown a limited predictive ability in elderly patients with acute coronary syndromes (ACS). No study explored the role of comprehensive geriatric assessment to predict in-hospital bleeding this clinical setting.The prospective multicentre LONGEVO-SCA registry included 532 unselected non-ST segment elevation ACS (NSTEACS) aged 80 years or older. Comorbidity (Charlson index), frailty (FRAIL scale), disability (Barthel index and Lawton-Brody cognitive status (Pfeiffer...
Background Coronary artery disease remains a major cause of death despite better outcomes ST‐segment–elevation myocardial infarction (STEMI). We aimed to analyze data from the Ruti‐STEMI registry in‐hospital, 28‐day, and 1‐year events in patients with STEMI over past 3 decades Catalonia, Spain, assess trends prognosis. Methods Results Between February 1989 December 2017, total 7589 were admitted consecutively. Patients grouped into 5 periods: 1994 (period 1), 1995 1999 2), 2000 2004 3), 2005...
The present study evaluates the safety and efficacy of Adipose Graft Transposition Procedure (AGTP) as a biological regenerative innovation for patients with chronic myocardial scar. This prospective, randomized single-center controlled included 10 established transmural scars. Candidates revascularization were randomly allocated into two treatment groups. In control arm (n=5), revascularizable area was treated CABG non-revascularizable left untouched. Patients in AGTP-treated (n=5) covered...
Patients with heart failure reduced ejection fraction (HFrEF) have not been shown to benefit from statins. We hypothesized that, by limiting disease progression in stable HFrEF of ischaemic etiology, the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab could reduce circulating troponin levels, a surrogate biomarker myocyte injury and atherosclerosis progression.The EVO-HF multicentre prospective randomized trial compared (420 mg/month administered subcutaneously)...
<b><i>Background:</i></b> Statins are recommended for secondary prevention. Our aims were to describe the proportion of very elderly patients receiving statins after non-ST segment elevation acute coronary syndrome (NST-ACS) and determine prognostic implications use. <b><i>Methods:</i></b> This prospective registry was performed in 44 hospitals that included ≥80 years discharged a NST-ACS from April 2016 September 2016....
To assess the prognostic impact of a routine invasive strategy according to frailty burden in patients with non-ST-segment elevation myocardial infarction (NSTEMI) from MOSCA-FRAIL clinical trial.
Context: Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements.Objective: The objective this study is to investigate the prognostic AHF.Methods: were determined at admission (n = 182) discharge 85). Primary endpoint was composite all-cause death HF rehospitalisation one year.Results: Discharge (HR 2.42 [95% CI 1.46–4], p 0.001) ΔST2 2.32 1.21–4.57], 0.01) but ST2, remained independently for primary after...
Objective Among patients with acute cardiac syndromes without coronary stenosis, the clinical, electrocardiographic, echocardiographic, and angiographic features of those a first myocardial infarction (AMI) were compared apical-ballooning syndrome (ABS). Methods Data consecutive admitted AMI (n=30) or ABS (n=45) reviewed. Results Patients older (72 vs. 56 years; P=0.001) presented higher frequency female sex (91 43%; P=0.001), triggering emotional physical stress (47 17%; P=0.003) lower rate...