A5059861964- Ionic liquids properties and applications
- Silk-based biomaterials and applications
- Enzyme Catalysis and Immobilization
- Extraction and Separation Processes
- Analytical Chemistry and Chromatography
- Phase Equilibria and Thermodynamics
- Electrochemical Analysis and Applications
- Phytochemical compounds biological activities
- Biochemical and Structural Characterization
- Catalysts for Methane Reforming
- Catalysis and Hydrodesulfurization Studies
- Electrochemical sensors and biosensors
- Electrospun Nanofibers in Biomedical Applications
- Metal complexes synthesis and properties
- Chemical Synthesis and Reactions
- Polymer Surface Interaction Studies
- Chemical and Physical Properties in Aqueous Solutions
- Membrane Separation and Gas Transport
- Solar Thermal and Photovoltaic Systems
- Nanoparticles: synthesis and applications
- Thermodynamic properties of mixtures
- Lanthanide and Transition Metal Complexes
- Antimicrobial Peptides and Activities
- Process Optimization and Integration
- Heat transfer and supercritical fluids
Universidad de Murcia
2016-2025
Instituto Murciano de Investigación Biosanitaria
2019
Centro Médico Sanitas Murcia
2016
Faculty (United Kingdom)
2016
Curcumin, extracted from the rhizome of Curcuma longa, has been widely used in medicine for centuries due to its anti-inflammatory, anti-cancer, anti-oxidant and anti-microbial effects. However, bioavailability during treatments is poor because low solubility water, slow dissolution rate rapid intestinal metabolism. For these reasons, improving therapeutic efficiency curcumin using nanocarriers (e.g., biopolymer nanoparticles) a research focus, foster delivery inside cells their small size...
The density and refractive index of 15 room temperature ionic liquids (ILs) grouped according to whether they had the same cation or anion have been measured at atmospheric pressure in a range from 293.15 K 343.15 K. Changes physical properties quantified as function alkyl chain length for each family. It has observed that liquid increases when decreases but not with molecular weight anion. We proposed new method assign volume component an IL explains trend, followed by all experimental data...
ABSTRACT Biopolymeric nanoparticles have attracted great research interest in the last few years due to their multiple applications. This article describes how high‐power ultrasounds are capable of enhancing dissolution process silk proteins ionic liquids (ILs) and fibroin (SFNs) can be obtained directly from silk/ionic liquid solution (SIL) by rapid desolvation polar organic solvents. The integrity is highly preserved during process, as confirmed sodium dodecyl sulfate‐polyacrylamide gel...
Naringenin (NAR), a flavonoid present in variety of fruits, vegetables and herbs, exhibits wide range pharmacological effects, including anticancer activity. Nevertheless, its application cancer therapy is limited due to low bioavailability at the tumour site because poor solubility water slow dissolution rate. To improve therapeutic efficacy NAR, emergent research looking into using nanocarriers. Silk fibroin (SF), from Bombyx mori silkworm, biocompatible biodegradable polymer with...
Several studies have stated that the process used for sericin removal, or degumming, from silk cocoons has a strong impact in fibroin integrity and consequently their mechanical biochemical properties after processing it into several biomaterials (e.g. fibers, films scaffolds) but still, there is lack of information on features nanoparticles. In this work, were degummed following four standard methods: autoclaving, short alkaline (Na2CO3) boiling, long boiling ultrasounds. The resultant...
The nanocrystal (NC) technology has become one of the most commonly used strategies for formulation poorly soluble actives. Given their large specific surface, NCs are mainly to enhance oral absorption Differently from conventional nanoparticles, which require use carrier materials and have limited drug loadings, NCs' loading approaches 100% since they formed pure surrounded by a thin layer stabilizer. In this work, we report covalent decoration curcumin with folic acid (FA) using EDC/NHS...
Silk fibroin from Bombyx mori caterpillar is an outstanding biocompatible polymer for the production of biomaterials. Its impressive combination strength, flexibility, and degradability are related to protein's secondary structure, which may be altered during manufacture biomaterial. The present study looks at silk structure nanoparticle using ionic liquids high-power ultrasound novel infrared spectroscopic approaches. spectrum fibers shows that they composed 58% β-sheet, 9% turns, 33%...
Pathogenic bacteria have the ability to develop antibiotic resistance mechanisms. Their action consists mainly in production of bacterial enzymes that inactivate antibiotics or appearance modifications prevent arrival drug at target point alteration itself, becoming a growing problem for health systems. Chitosan–gold nanoparticles (Cs-AuNPs) been shown as effective bactericidal materials avoiding damage human cells. In this work, Cs-AuNPs were synthesized using chitosan reducing agent, and...
Rosmarinic acid (RA), one of the most important polyphenol-based antioxidants, has drawn increasing attention because its remarkable bioactive properties, including anti-inflammatory, anticancer and antibacterial activities. The aim this study was to synthesize characterize RA-loaded silk fibroin nanoparticles (RA-SFNs) in terms their physical–chemical features composition, investigate antitumor activity against human cervical carcinoma breast cancer cell lines (HeLa MCF-7). Compared with...
A method for the synthesis of cellulose nanoparticles using ionic liquid 1-ethyl-3-methylimidazolium acetate has been optimised. The use a highly biocompatible biopolymer such as cellulose, together with an liquid, makes this promising way to obtain good capability drug carrying. operating conditions have optimised based on average hydrodynamic diameter, polydispersity index, determined by Dynamic Light Scattering (DLS) and Z-potential, obtained phase analysis light scattering (PALS),...
The development of new biomaterials from natural fibres in the field biomedicine have attracted great interest recent years. One most studied has been silk fibroin produced by Bombyx mori worm, due to its excellent mechanical properties and biodegradability bioavailability. Among different that can be prepared fibroin, hydrogels considerable attention their potential use fields, such as scaffolding, cell therapy biomedical application. Hydrogels are essentially a three-dimensional network...
The ongoing pursuit of efficient solar thermal energy systems has driven significant interest in the development advanced nanofluids, particularly those utilizing carbon-based nanostructures such as graphene nanoplatelets (GNP) and carbon nanotubes (CNTs). These materials, when dispersed base fluids like water or ionic liquids, have gained attention for their tunable thermophysical properties, including conductivity, viscosity, specific heat capacity. This positioned them promising...
Nineteen different 1,3-dialkylimidazolium-based ionic liquids (ILs) were used as reaction media for the synthesis of butyl butyrate by transesterification from vinyl and 1-butanol catalyzed Candida antarctica lipase B (CaLB). The was also carried out in hexane a reference solvent. In all water-immiscible ILs assayed, enzymatic activity selectivity higher than that obtained hexane. However, water-miscible ILs, lower solvent, although they showed >99.99% selectivity. Two solvent properties,...