A5057871048- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Biochemical and Structural Characterization
- 3D Printing in Biomedical Research
- Periodontal Regeneration and Treatments
- Antimicrobial Peptides and Activities
- Polymer Surface Interaction Studies
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- Nerve injury and regeneration
- Academic Writing and Publishing
- Silkworms and Sericulture Research
- biodegradable polymer synthesis and properties
- Advanced Materials and Mechanics
- Osteoarthritis Treatment and Mechanisms
- Collagen: Extraction and Characterization
- Neurobiology and Insect Physiology Research
- Nanofabrication and Lithography Techniques
- Insect and Arachnid Ecology and Behavior
- Viral Infectious Diseases and Gene Expression in Insects
- Phytochemical compounds biological activities
- Advanced Sensor and Energy Harvesting Materials
- Wound Healing and Treatments
- Tendon Structure and Treatment
Tufts University
2016-2025
Adult and Pediatric Dermatology
2000-2024
University of Calgary
2023
Centre National de la Recherche Scientifique
2002-2023
Université de Montpellier
2023
Institut de Recherche pour le Développement
2023
Marine Biodiversity Exploitation and Conservation
2023
Ifremer
2023
Boston Children's Hospital
1977-2022
University of Pennsylvania
2022
Reversible Implants Silicon electronics are generally designed to be stable and robust—it would counterproductive if the key parts of your computer or cell phone slowly dissolved away while you were using it. In order develop transient for use as medical implants, Hwang et al. (p. 1640 , see cover) produced a complete set tools materials that needed make standard devices. Devices have specific lifetime, after which component materials, such porous silicon silk, resorbed by body.
We report a study of self-assembled beta-pleated sheets in B. mori silk fibroin films using thermal analysis and infrared spectroscopy. may stand as an exemplar fibrous proteins containing crystalline beta-sheets. Materials were prepared from concentrated solutions (2−5 wt % water) then dried to achieve less ordered state without Crystallization was effected either by heating the above glass transition temperature (Tg) holding isothermally or exposure methanol. The fractions secondary...
Three fabrication techniques, freeze-drying, salt leaching and gas foaming, were used to form porous three-dimensional silk biomaterial matrixes. Matrixes characterized for morphological functional properties related processing method conditions. The porosity of the leached scaffolds varied between 84 98% with a compressive strength up 175 ± 3 KPa, foamed had porosities 87−97% 280 4 KPa. freeze-dried prepared at different freezing temperatures (−80 −20 °C) subsequently treated concentrations...
Control of silk fibroin concentration in aqueous solutions via osmotic stress was studied to assess relationships gel formation and structural, morphological, functional (mechanical) changes associated with this process. Environmental factors potentially important the vivo processing were also determine their contributions Gelation affected by temperature, Ca2+, pH, poly(ethylene oxide) (PEO). time decreased increase protein concentration, decrease addition PEO. No change gelation observed...
Silks are being reassessed as biomaterial scaffolds due to their unique mechanical properties, opportunities for genetic tailoring of structure and thus function, recent studies clarifying biocompatibility. We report on the covalent decoration silk films with integrin recognition sequences (RGD) well parathyroid hormone (PTH, 1-34 amino acids) a modified PTH (mPTH) involved in induction bone formation. Osteoblast-like cell (Saos-2) responses decorated indicate that proteins serve suitable...
Electrospinning for the formation of nanoscale diameter fibers has been explored high-performance filters and biomaterial scaffolds vascular grafts or wound dressings. Fibers with diameters provide benefits due to high surface area. In present study we explore electrospinning protein-based biomaterials fabricate membranes from regenerated silkworm silk, Bombyx mori, solutions. To improve processability protein solution, poly(ethylene oxide) (PEO) molecular weight 900 000 was blended silk...
Growth factors, hormones, and other regulatory molecules are traditionally required in tissue engineering studies to direct the differentiation of progenitor cells along specific lineages. We demonstrate that mechanical stimulation vitro, without ligament-selective exogenous growth induces mesenchymal from bone marrow into a ligament cell lineage preference alternative paths (i.e., or cartilage lineages). A bioreactor was designed permit controlled application ligament-like multidimensional...