A5103016753- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Pleural and Pulmonary Diseases
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- RNA and protein synthesis mechanisms
- Cancer Cells and Metastasis
- Non-Invasive Vital Sign Monitoring
- Circular RNAs in diseases
- interferon and immune responses
- Lung Cancer Research Studies
- Silk-based biomaterials and applications
- PI3K/AKT/mTOR signaling in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- ATP Synthase and ATPases Research
- DNA Repair Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Radiotherapy Techniques
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Gastric Cancer Management and Outcomes
Shanghai Jiao Tong University
2016-2025
Guangzhou Medical University
2021-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Zhongshan Hospital
2025
Fudan University
2025
Sun Yat-sen University
2025
Shanghai Chest Hospital
2014-2024
Guangdong Academy of Medical Sciences
2024
MicroRNAs (miRNAs) are endogenous noncoding RNAs, which negatively regulate gene expression. To determine genomewide miRNA DNA copy number abnormalities in cancer, 283 known human genes were analyzed by high-resolution array-based comparative genomic hybridization 227 ovarian breast and melanoma specimens. A high proportion of loci containing exhibited alterations cancer (37.1%), (72.8%), (85.9%), where observed >15% tumors considered significant for each gene. We identified 41 with changes...
MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as negative gene regulators. miRNA deregulation is involved in the initiation and progression human cancer; however, underlying mechanism its contributions to genome-wide transcriptional changes cancer still largely unknown. We studied epithelial ovarian by integrative genomic approach, including microarray (n = 106), array-based comparative hybridization 109), cDNA 76), tissue array 504). expression markedly...
AbstractTumor growth results in hypoxia. Understanding the mechanisms of gene expression reprogramming under hypoxia may provide important clues to cancer pathogenesis. We studied miRNA genes that are regulated by ovarian cell lines TaqMan assay containing 157 mature miRNAs. MiR-210 was most prominent consistently stimulated hypoxic conditions. evidence for involvement HIF signaling pathway miR-210 regulation. Biocomputational analysis and vitro assays demonstrated e2f transcription factor 3...
Spider silk fibers have remarkable mechanical properties that suggest the component proteins could be useful biopolymers for fabricating biomaterial scaffolds tissue formation. Two bioengineered protein variants from consensus sequence of major dragline Nephila clavipes were cloned and expressed to include RGD cell-binding domains. The engineered silks characterized by CD FTIR showed structural transitions random coil insoluble β-sheet upon treatment with methanol. recombinant processed into...
We reported that the class I HDAC inhibitor entinostat induced apoptosis in erbB2-overexpressing breast cancer cells via downregulation of erbB2 and erbB3. Here, we study molecular mechanism by which dual-targets erbB2/erbB3. Treatment with had no effect on erbB2/erbB3 mRNA, suggesting a transcription-independent mechanism. Entinostat decreased endogenous but not exogenous erbB2/erbB3, indicating it did alter their protein stability. hypothesized might inhibit translation specific miRNAs....
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality in world. Late diagnosis one most significant reasons for high rate cancer. The identification microRNAs (miRNAs) has opened a new field molecular purpose present study was to investigate whether plasma miRNAs may be used as biomarkers early-stage NSCLC. A total 232 participants, including 149 NSCLC patients and 83 healthy controls, were recruited between July 2012 May 2014. We measured levels 10 (miR-30d,...
Abstract Mutations in BRCA1 and BRCA2 account for a significant proportion of hereditary breast cancers. Earlier studies have shown that inherited sporadic tumors progress along different somatic genetic pathways global gene expression profiles distinguish between these groups. To determine whether genomic similarly discriminate among BRCA1, BRCA2, tumors, we established DNA copy number using comparative hybridization to BAC-clone microarrays providing <1 Mb resolution. Tumor was...
Abstract The protein kinase C (PKC) family plays a key regulatory role in wide range of cellular functions as well various cancer-associated signal transduction pathways. Here, we investigated the genomic alteration and gene expression most known PKC members human ovarian cancer. DNA copy number genes was screened by high-resolution array-based comparative hybridization 89 cancer specimens. Five exhibited significant gains, including PKCι (43.8%), PKCβ1 (37.1%), PKCγ (27.6%), PKCζ (22.5%),...
Abstract Purpose: The phosphatidylinositol 3′-kinase (PI3K) family plays a key regulatory role in various cancer-associated signal transduction pathways. Here, we investigated the genomic alterations and gene expression of most known PI3K members human epithelial ovarian cancer. Experimental Design: DNA copy number genes was screened by high-resolution array comparative hybridization 89 cancer specimens. mRNA level analyzed microarray retrieval approach, further validated real-time reverse...
The continuous vital signs monitoring allows clinicians to timely assess the physiological conditions of patient in ICU. Internet Things (IoT) hospital that integrated various sensors (e.g. cameras) may enable intelligent healthcare. In this paper, we proposed a remote system exploits CCTV cameras an IoT infrastructure as optical for non-contact measurement, extending its scope from surveillance warding. implemented latest camera photoplethysmography algorithms cardio-respiratory...
Epithelial ovarian cancer is the most frequent cause of gynecologic malignancy-related mortality in women. To identify genes up-regulated cancer, PCR-select cDNA subtraction was done and Drosophila Eyes Absent Homologue 2 (EYA2) isolated as a promising candidate. The transcriptional coactivator eya controls essential cellular functions during organogenesis Drosophila. EYA2 mRNA found to be by real-time reverse transcription-PCR, whereas its protein product detected 93.6% specimens...
Epithelial-to-mesenchymal transition (EMT) contributes to the invasion and metastasis of epithelial tumors. Sirtuin 6 (SIRT6), an NAD-dependent deacetylase, is known promote non-small cell lung cancer (NSCLC).In this work, we determined role SIRT6 in EMT NSCLC cells identified key EMT-related genes involved oncogenic activity SIRT6.We report that depletion inhibits transforming growth factor-β1 (TGF-β1)-induced A549 H1299 cells, which rescued by ectopic expression SIRT6. Knockdown leads a...
BackgroundNon-invasive lung adenocarcinoma could benefit from limited resection, nonetheless, there is a lack of method to determine preoperative tumour invasiveness. We aimed investigate whether folate receptor-positive circulating cells (FR+-CTCs) in combination with maximum diameter (MTD) determines, before surgery, the invasiveness small-sized, indeterminate solitary pulmonary nodules (SPNs).MethodsA total 382 patients suspicious on computed tomography who were expected undergo resection...
Osimertinib (AZD9291), a third-generation EGFR-tyrosine kinase inhibitor, can effectively prolong survival in non-small cell lung cancer (NSCLC) patients with EGFR mutations, particularly T790M mutations; however, acquired resistance to AZD9291 is inevitable, thus exploration of the targets urgent.
Robotic thoracoscopic surgery was first done in mainland China 2009 and has gained popularity the past few years. Here, we present largest Chinese series of robotic lobectomy for early-stage non-small cell lung cancer (NSCLC) to date. We aimed compare perioperative outcomes our three-arm robotic-assisted (RAL3) video-assisted (VAL) p-stage I NSCLC report approach anatomic lobar resections center.We retrospectively collected analyzed data 1075 stage patients who underwent minimally invasive...
Co-delivery of chemotherapeutics and immunostimulant or chemoimmunotherapy is an emerging strategy in cancer therapy. The precise control the targeting release agents critical this methodology. This article proposes asynchronous chemotherapeutic immunostimulants to realize synergistic effect between chemotherapy immunotherapy. To obtain a proof-of-concept, co-delivery system was prepared via drug-delivering-drug (DDD) for cytosolic Poly I:C, synthetic dsRNA analog activate RIG-I signaling,...