A5019443654- Estrogen and related hormone effects
- Hypothalamic control of reproductive hormones
- Neuropeptides and Animal Physiology
- Hormonal and reproductive studies
- Foreign Body Medical Cases
- Neuroendocrine regulation and behavior
- Prostate Cancer Treatment and Research
- Obstructive Sleep Apnea Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Stress Responses and Cortisol
- Cerebrospinal fluid and hydrocephalus
- Growth Hormone and Insulin-like Growth Factors
- Airway Management and Intubation Techniques
- Reproductive Biology and Fertility
- Tracheal and airway disorders
- Restraint-Related Deaths
- Receptor Mechanisms and Signaling
- Cancer-related cognitive impairment studies
- Pneumonia and Respiratory Infections
- Amyotrophic Lateral Sclerosis Research
- Cardiovascular and Diving-Related Complications
- Nitric Oxide and Endothelin Effects
- Sexual Differentiation and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
Hospital Universitario Virgen de la Arrixaca
2010-2024
Universidad de Murcia
1992-2022
Hospital Clínico Universitario Virgen de la Victoria
2021
Pulmonary Associates
2020
Hospital Universitario 12 De Octubre
2018
Universidad de Los Andes
2013-2016
Hospital Universitario Puerta de Hierro Majadahonda
2016
Hospital Reina Sofía de Murcia
2000-2012
Hospital Vega Baja
2012
Corning (United States)
2011
Mammalian reproduction is dependent upon intermittent delivery of luteinizing hormone-releasing hormone (LHRH) to the anterior pituitary. This mode secretion required sensitize maximally gonadotrophs LHRH stimulation and regulate gonadotropin gene expression. While pulsatile in nature, origin pulse generator unknown. In this report, we show that oscillator could be located within neuronal network. When immortalized neurons are placed into a perifusion system, secreted medium fashion under...
A number of conditions, including osteoporosis, frailty, and sexual dysfunction in both men women have been improved using androgens. However, androgens are not widely used for these indications because the side effects associated with drugs. We describe an androgen receptor (AR) ligand that maintains expected anabolic activities substantially diminished activity prostate. LGD2226 is a nonsteroidal, nonaromatizable, highly selective AR, exhibiting virtually no affinity other intracellular...
We have analyzed the role of nitric oxide (NO), an unorthodox and novel neuromodulator, on luteinizing hormone-releasing hormone (LHRH) secretion. Sodium nitroprusside (SNP), NO donor, was used to challenge LHRH neurons using both hypothalamic explants immortalized neuronal cell line (GT1 cells) in vitro. In paradigms, SNP able stimulate release a dose-dependent manner. This action accompanied by elevation extra- intra-cellular cGMP levels. addition, exposure cells (GT1-7 increasing...
Abstract The objective of this article is to assess the safety intraspinal infusion autologous bone marrow mononuclear cells (BMNCs) and, ultimately, look for histopathological signs cellular neurotrophism in amyotrophic lateral sclerosis (ALS) patients. We conducted an open single arm phase I trial. After 6 months observation, BMNCs were infused into posterior spinal cord funiculus. Safety was primary endpoint and defined as absence serious transplant-related adverse events. In addition,...
The present study was designed to analyze in detail the effects of L-glutamate (L-Glu) and its agonists on release LHRH from arcuate nucleus-median eminence (AN-ME) fragments vitro. Fragments adult male rats were incubated Krebs-Ringer bicarbonate buffer presence different concentrations L-Glu, kainate (KA), N-methyl-D-aspartic acid (NMDA), quisqualate (QA). L-Glu at 10-20 mM evoked a significant increase basal release, while D-glutamate similar ineffective. Partial depolarization with 14 K+...
We have recently reported that a subpopulation of galanin (GAL)-immunoreactive perikarya in the preoptic area near organum vasculosum lamina terminalis (OVLT) has morphological characteristics similar to those LHRH-containing neurons. In fact, both peptides are colocalized neurons male rat brain. these studies we describe sexual differences incidence colocalizing GAL and LHRH this region. rats, about 20% LHRH-immunoreactive cells diagonal band Broca medial also immunoreactive for GAL....
Galanin (GAL), a 29-amino acid peptide originally isolated from porcine intestine, has been shown to be widely distributed not only in the gut, but also central nervous system. Several studies have that GAL participates hypothalamic regulation of PRL, GH, and LH secretion. In this study, we evaluate effects rat (rGAL) on LHRH prostaglandin (PG) E2 release arcuate nucleus-median eminence fragments vitro. Fragments were incubated for 30-min periods Krebs-Ringer bicarbonate buffer containing...
Background: Kidney transplantation is the preferred treatment for end-stage renal disease, but delayed graft function remains a significant complication. Cold ischemia during organ preservation can lead to release of danger-associated molecular patterns (DAMPs), which may influence outcomes. This study aimed quantify DAMPs in kidney fluid and assess their correlation with (DGF). Methods: Preservation samples from 88 deceased donors were analyzed various DAMPs, including mitochondrial DNA...
The pituitary glycoprotein hormones, luteinizing hormone and follicle-stimulating (FSH), act through their cognate receptors to initiate a series of coordinated physiological events that results in germ cell maturation. Given the importance FSH regulating folliculogenesis fertility, development mimetics has been sought treat infertility. Currently, purified recombinant human are only receptor (FSH-R) agonists available for infertility treatment. By screening unbiased combinatorial chemistry...
Journal Article Endogenous galanin modulates the gonadotropin and prolactin proestrous surges in rat Get access F J López, López 1Reproductive Neuroendocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Search for other works by this author on: Oxford Academic Google Scholar E H Meade, Jr, Jr A Negro-Vilar Endocrinology, Volume 132, Issue 2, 1 February 1993, Pages 795–800, https://doi.org/10.1210/endo.132.2.7678800 Published: 01 1993
The androgen receptor is a member of the extended family nuclear receptors and widely distributed throughout body. Androgen therapy used to compensate for low levels natural hormones testosterone (T) dihydrotestosterone consists administration T, prodrugs thereof, or synthetic androgens. However, currently available androgens have many drawbacks. We identified 6-dialkylamino-4-trifluoromethylquinolin-2(1H)-ones as orally tissue-selective modulators.
The relationship between asthma and vitamin D deficiency has been known for some time. However, interventional studies conducted in this regard have shown conflicting results.To evaluate the efficacy of supplementation asthmatic patients improving degree control asthma.Randomised, triple-blind, placebo-controlled, parallel-group study adult with serum 25-hydroxyvitamin-D3 <30 ng/mL. intervention group received oral 16 000 IU calcifediol per week, had placebo added to their usual treatment....
Treatment of inflammation is often accomplished through the use glucocorticoids. However, their limited by side effects. We have examined activity a novel glucocorticoid receptor ligand that binds efficiently and strongly represses inflammatory gene expression. This compound has potent antiinflammatory in vivo transcription cytokine monocyte chemoattractant protein-1 induces IL-10. The demonstrates differential regulation, compared with commonly prescribed glucocorticoids, effectively...
The glycoprotein hormones (LH, FSH, and TSH) are critical to the maintenance of physiological homeostasis control reproduction. However, despite an obvious utility for synthetic pharmacological agents, there few reports selective, nonpeptide agonists or antagonists receptors these hormones. We have identified characterized a novel molecule capable inhibiting action FSH. This compound,...
The present studies were designed to obtain a detailed characterization of pulsatile PRL secretory patterns under basal conditions and explore the role dopamine (DA) vasoactive intestinal peptide (VIP) in genesis pulses. Adult intact male rats received chronic indwelling jugular canula bled at 3-min intervals for periods ranging from 90–150 min. Pulse analysis was performed using algorithm Detect. Blockade DA receptors with domperidone, pimozide, or haloperidol resulted 2-fold increase pulse...
The androgen receptor is a ligand inducible transcription factor that involved in broad range of physiological functions. Here we describe the discovery new class orally available selective modulators. lead compound, 6-[(2R,5R)-2-methyl-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl]-4-trifluoromethylquinolin-2(1H)-one (6a), showed excellent anabolic activity muscle with reduced effect on prostate rat model hypogonadism. compound also improved bone strength post-menopausal osteoporosis.
Recent interest in orally available androgens has fueled the search for new use hormone replacement therapy and as anabolic agents. In pursuit of this, we have discovered a series novel androgen receptor modulators derived from 7H-[1,4]oxazino[3,2-g]quinolin-7-ones. These compounds were synthesized evaluated competitive binding assays an transcriptional activation assay. A number demonstrated single-digit nanomolar agonist activity vitro. addition, lead compound (R)-16e was active...
Neuronal networks controlling endocrine events present synchronous activity which is required for maintaining physiological functions, including reproduction. Although pulsatile hormone secretion of paramount importance, the mechanism(s) by secretory episodes are generated remain largely unknown. Nitric oxide (NO) has become prototype a new family signaling molecules in body. diffuses from source cell and controls neighboring neurons as well itself retrograde messenger. Cells luteinizing...