A5049065887- Chronic Disease Management Strategies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heart Failure Treatment and Management
- Frailty in Older Adults
- Atrial Fibrillation Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Technology
- Pharmaceutical Practices and Patient Outcomes
- Cardiovascular Function and Risk Factors
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Emergency and Acute Care Studies
- Healthcare cost, quality, practices
- Long-Term Effects of COVID-19
- Blood Pressure and Hypertension Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Palliative Care and End-of-Life Issues
- Nutrition and Health in Aging
- Cardiac pacing and defibrillation studies
- Healthcare Policy and Management
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
- Nursing Diagnosis and Documentation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Hospital Royo Villanova
2016-2025
Universidad de Zaragoza
2014-2025
Hospital Universitario La Paz
2014-2024
Sociedad Española de Medicina Interna
2000-2023
Hospital General Universitario Gregorio Marañón
2023
Health Foundation
2023
Spanish Society of Family and Community Medicine
2011-2022
Instituto de Investigación Sanitaria Aragón
2014-2022
Research Network (United States)
2022
Spanish Society of Hematology and Hemotherapy
2022
<h3>Background</h3> Infliximab (IFX) is a monoclonal antibody against tumour necrosis factor α that effective for treating spondyloarthritis (SpA). However, after initial success of the drug some patients lose responsiveness or develop infusion reactions, which may be related to development antibodies drug. <h3>Objective</h3> To investigate clinical relevance infliximab (ATI) formation in with SpA undergoing IFX treatment over prolonged period. <h3>Methods</h3> 94 treated from 1999 2010 were...
We aimed to analyze baseline socio-demographic and clinical factors associated with an increased likelihood of mortality in men women coronavirus disease (COVID-19). conducted a retrospective cohort study (PRECOVID Study) on all 4412 individuals laboratory-confirmed COVID-19 Aragon, Spain, followed them for at least 30 days from entry. described the characteristics patients cohort. Age-adjusted logistic regressions models were performed based demographic variables. All analyses stratified by...
Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS is not known. The aim this study was evaluate the clinical characteristics and outcome IS hospitalized with patients.We designed retrospective cohort study. We included all laboratory-confirmed from SEMI-COVID-19 Registry, large multicentre national in Spain, March 27th until June 19th, 2020. used multivariable logistic regression assess adjusted odds ratios (aOR) in-hospital death among...
Atrial fibrillation (AF) in the elderly is a complex condition. It has direct impact on underuse of antithrombotic therapy reported this population. All patients aged ≥75 years with AF have an individual yearly risk stroke >4 %. However, hemorrhage also increased. Moreover, population it common presence other comorbidities, cognitive disorders, falls and polymedication. This may lead to anticoagulant therapy. Direct oral anticoagulants (DOACs) are at least as effective conventional therapy,...
The correct management of patients with multimorbidity remains one the main challenges for healthcare systems worldwide. In this study, we analyze existence patterns in general population based on gender and age. We conducted a cross-sectional study individuals all ages from EpiChron Cohort, Spain (1,253,292 subjects), analyzed presence systematic associations among chronic disease diagnoses using exploratory factor analysis. identified clinically described total 14 different (12 women 12...
Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS COVID-19 requiring hospitalization analyze its association in-hospital mortality. observational, retrospective, multicenter cohort analyzed 12 170 admitted 150 Spanish centers included SEMI-COVID-19 Network. We compared AS, defined as pulse...
Anti-TNF drugs have proven to be effective against spondyloarthritis (SpA), although 30% of patients fail respond or experience adverse events leading treatment discontinuation. In rheumatoid arthritis, the presence anti-drug antibodies (ADA) first TNF inhibitor influences outcome after switching. Our aim was assess whether response a second anti-TNF drug is related previous development ADA SpA patients. Forty-two began failing therapy. Clinical activity assessed by Ankylosing Spondylitis...
The antiphospholipid antibodies present in syndrome (APS) are directed at a number of phospholipid-binding proteins: β 2 glycoprotein I (β GPI), prothrombin, and so on. Antibodies GPI accepted as classification criterion for APS, while the presence antiprothrombin is not. In article, we investigated possible role antiphosphatidylserine/prothrombin (aPS/PT) marker APS on cohort 295 individuals with (95 primary 45 secondary APS) APS-related diseases. We found aPS/PT to be highly associated...
To create a tool to identify drugs and clinical situations that offers an opportunity of deprescribing in patients with multimorbidity.A literature review completed electronic brainstorming, subsequently, panel experts using the Delphi methodology were applied. The assessed criteria identified brainstorming as possible for deprescribing. They also asked assess influence life prognosis each criterion. A was composed most appropriate according strength their evidence, usefulness multimorbidity...
Breast reconstruction with the deep inferior epigastric perforator (DIEP) flap can be associated complications such as fat necrosis. The authors' objective was to assess safety and efficacy of fluorescent angiography indocyanine green reduce necrosis.The authors designed a parallel, randomized, controlled clinical trial for unilateral breast reconstruction. poorly vascularized tissues DIEP were removed based on evaluation in group 1 angiographic criteria 2. recorded dimensions, perfusion...
Background: Chronic obstructive pulmonary disease (COPD) is associated with multiple comorbidities, which impact negatively on patients and are often underdiagnosed, thus lacking a proper management due to the absence of clear guidelines. Purpose: To elaborate expert recommendations aimed help healthcare professionals provide right care for treating COPD comorbidities. Methods: A modified RAND-UCLA appropriateness method consisting nominal groups draw up consensus (6 Spanish experts)...
The presence of oxidative stress, telomere shortening, and apoptosis in polypathological patients (PP) with sarcopenia frailty remains unknown.Multicentric prospective observational study order to assess stress markers (catalase, glutathione reductase (GR), total antioxidant capacity reactive oxygen species (TAC-ROS), superoxide dismutase (SOD)), absolute length (aTL), (DNA fragmentation) peripheral blood samples a hospital-based population PP. Associations these biomarkers sarcopenia,...